Hyaluronic acid targeted and pH-responsive nanocarriers based on hollow mesoporous silica nanoparticles for chemo-photodynamic combination therapy

Recent Advances in pH- or/and Photo-Responsive Nanovehicles

“…The Fa-ONB lipid could be cleaved by both an acidic environment and UV light irradiation because of the o -nitrobenzyl ester bond. DOX-loaded liposomes composed of Fa-ONB lipid and dipalmitoylphosphatidylcholine (FOBD) showed an increase in drug release efficiency according to pH change and UV irradiation synergistically ( Figure 14 ) [ 173 ]. Nisar et al engineered a photocleavable and pH-responsive crosslinked nanovehicle.…”

“…The surface of HMSNs was modified with hyaluronic acid (HA) via pH-sensitive Schiff base bonds (RB-DOX@HMSNs-N=C-HA). The pH-responsive Schiff base bonds were designed to be hydrolyzed under acidic conditions, leading to DOX and RB release from HMSNs and inhibition of tumor cell viability under light illumination [ 173 ]. In a recent study, they fabricated a targeted HMSN-based DDS for cancer chemo-PDT.…”

A Review of Mesoporous Silica Nanoparticle Delivery Systems in Chemo-Based Combination Cancer Therapies

“…Integration with MSNs can prevent the aggregation of PSs as well as improve the targeting ability and biocompatibility of PSs, leading to reduced side-effects and stronger anticancer efficacy (Zhao et al, 2010 ; Yao et al, 2015 ; Yang G. et al, 2016 ). Several MSN vehicles have been reported to be able to co-deliver anti carcinogens and PSs into cancer cells (Zhang et al, 2016 ; Kankala et al, 2017 ; Chen et al, 2020 ; Fu et al, 2020 ; Wang H. et al, 2020 ), and these studies showed several advantages to these combination systems such as enhanced biocompatibility, improved cellular uptake of the payloads, and enhanced therapeutic efficiency (Yan et al, 2018 ). In one such example, Fang et al ( 2019 ) designed a hollow MSN nanoparticles (HMSNs) based nanoplatform into which the chemotherapeutic agent DOX and photosensitizer chlorine e6 (Ce6) were co-loaded at 9.56 and 16.68% (w/w), respectively.…”

Functionalization of Photosensitized Silica Nanoparticles for Advanced Photodynamic Therapy of Cancer

“…In this regard, silica nanoparticles (SN) have attracted attention as carriers for drug delivery due to their properties, which include reduced toxicity, good biocompatibility, high surface area, easy functionalization, optical transparency, and low cost [ 56 , 57 ]. PS-loaded silica nanoparticles have been reported as promising singlet oxygen generator platforms, improving the photoactive drug delivery by enhancing PS poor solubility and selectivity for cancer cells [ 58 , 59 , 60 , 61 , 62 ]. The PS can be physically encapsulated or covalently attached to the internal or external surface of the silica nanoparticles [ 63 , 64 , 65 , 66 , 67 ].…”

“…In this work, different PSs ( Figure 1 ) were tethered to the external surface of 50 nm MSNs. First, three commercially available PSs, Rose Bengal (RB), Chlorin e6 (C6), and Thionine (Th), recognized as suitable singlet oxygen generators and extensively employed in PDT, were used [ 6 , 9 , 10 , 11 , 59 , 91 , 92 , 93 ]. These dyes already have functional groups in their molecular structure (carboxylic in Rose Bengal and Chlorin e6 and amine in Thionine) and can be easily grafted to the external surface of MSNs.…”