Hyaluronidase-incorporated hyaluronic acid–tyramine hydrogels for the sustained release of trastuzumab

Xu, Keming; Lee, Fan; Gao, Shujun; Tan, Min‐Han; Kurisawa, Motoichi

doi:10.1016/j.jconrel.2015.08.015

Cited by 59 publications

(45 citation statements)

References 32 publications

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“…On the same line of work, a new hyaluronidase incorporated-hyaluronan-tyramine hydrogel was developed for the delivery of trastuzumab, an antibody drug against breast cancer. In vitro release studies showed an antibody tunable release accompanied by the hydrogel degradation controlled by the concentration of hyaluronidase, as well as trastuzumab-dependent inhibition on the proliferation on cells [ 198 ].…”

Section: Polysaccharides From Marine Animalsmentioning

confidence: 99%

Marine Origin Polysaccharides in Drug Delivery Systems

2016

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Oceans are a vast source of natural substances. In them, we find various compounds with wide biotechnological and biomedical applicabilities. The exploitation of the sea as a renewable source of biocompounds can have a positive impact on the development of new systems and devices for biomedical applications. Marine polysaccharides are among the most abundant materials in the seas, which contributes to a decrease of the extraction costs, besides their solubility behavior in aqueous solvents and extraction media, and their interaction with other biocompounds. Polysaccharides such as alginate, carrageenan and fucoidan can be extracted from algae, whereas chitosan and hyaluronan can be obtained from animal sources. Most marine polysaccharides have important biological properties such as biocompatibility, biodegradability, and anti-inflammatory activity, as well as adhesive and antimicrobial actions. Moreover, they can be modified in order to allow processing them into various shapes and sizes and may exhibit response dependence to external stimuli, such as pH and temperature. Due to these properties, these biomaterials have been studied as raw material for the construction of carrier devices for drugs, including particles, capsules and hydrogels. The devices are designed to achieve a controlled release of therapeutic agents in an attempt to fight against serious diseases, and to be used in advanced therapies, such as gene delivery or regenerative medicine.

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Section: Polysaccharides From Marine Animalsmentioning

confidence: 99%

Marine Origin Polysaccharides in Drug Delivery Systems

2016

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“…Tumor cell growth was suppressed by anticancer molecules released from the hydrogels and significant tumor tissue regression was observed by implanting HA–Ph hydrogels containing these molecules compared with injecting these molecules alone. In a study with trastuzumab, hyaluronidase was also incorporated into the HA–Ph hydrogel for the sustained release of trastuzumab (cationic) electrically cross‐linked with HA–Ph (anionic) by degrading the HA molecules . For gelatin–Ph hydrogels as a carrier for sustained release of hydrophobic drugs, Thi et al.…”

Section: Biomedical and Biopharmaceutical Applicationsmentioning

confidence: 99%

“…In situ hydrogelation under mild reaction conditions and the controllable biodegradability of hydrogels by using appropriate materials and preparation conditions are attractive for in vivo drug and protein delivery.I nastudy with bovine serum albuminasamodel protein and poly(glutamic acid)-Ph, the re-lease profile from the hydrogel was controlled by alteringt he ratio of H 2 O 2 and HRP. [18] The potentialf or cancert herapy was reported for HA-Phh ydrogels that incorporated trastuzumab [67] and interferon-alpha 2a. [68] Tumor cell growth was suppressed by anticancer molecules released from the hydrogels and significant tumort issue regression was observed by implanting HA-Phh ydrogels containing these molecules compared with injecting these molecules alone.…”

Section: Drug and Protein Deliverybyu Sing Acellular Hydrogelsmentioning

confidence: 99%

“…In as tudy with trastuzumab, hyaluronidase was also incorporated into the HA-Ph hydrogel for the sustained releaseo ft rastuzumab (cationic) electrically cross-linked with HA-Ph( anionic) by degrading the HA molecules. [67] For gelatin-Ph hydrogels as ac arrier for sustained release of hydrophobic drugs,T hi et al conjugated partly oxidized beta-cyclodextrin (b-CD) with gelatin-Ph. [69] CDs facilitate hydrophobic drug delivery by both improving drug loading and subsequently exertingc ontrol over the rate of drug release.…”

Section: Drug and Protein Deliverybyu Sing Acellular Hydrogelsmentioning

confidence: 99%

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Horseradish Peroxidase Catalyzed Hydrogelation for Biomedical, Biopharmaceutical, and Biofabrication Applications

Sakai

Nakahata

2017

Chemistry An Asian Journal

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Horseradish peroxidase (HRP)-catalyzed hydrogelation has attracted much attention owing to the ease of handling, high biocompatibility, and processability. This review summarizes recent developments, including cutting-edge research into the use of HRP-mediated hydrogelation toward biomedical, biopharmaceutical, and biofabrication applications. From the viewpoint of polymer chemistry, the basic chemistry behind hydrogelation, the structure-property relationship, and hybridization of multiple materials by using HRP-catalyzed hydrogelation are summarized. From the chemical engineering perspective, strategies for controlling hydrogelation kinetics, hydrogel characteristics, and hydrogelation processes are summarized and discussed in detail. Strategies for obtaining biomaterials for medical and pharmaceutical use, and biofabrication for tissue engineering and regenerative medicine emerge by unifying the aspects of HRP-mediated hydrogelation.

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“…Such biodegradation rate is anticipated to allow the click-hydrogels to degrade while new tissue is forming. Overall, these results represent a major improvement in comparison to previous works 33,34,[54][55][56] where HA-based hydrogels subjected to HAse degradation were only stable for shorter periods, between 24 h 54 and 14 days. 55 Once satisfied with the mechanical performance of our click-hydrogels, we assessed their potential for biomedical applications by evaluating the cytotoxicity of the degradation products in the first instance.…”

Section: Biomaterials Science Papermentioning

confidence: 46%