Hyams grading as a predictor of metastasis and overall survival in esthesioneuroblastoma: a meta‐analysis

Goshtasbi, Khodayar; Abiri, Arash; Abouzari, Mehdi; Sahyouni, Ronald; Wang, Beverly Y.; Tajudeen, Bobby A.; Hsu, Frank P.K.; Gilbert, Clare; Kuan, Edward C.

doi:10.1002/alr.22373

Cited by 55 publications

(52 citation statements)

References 52 publications

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“…These findings do not reflect what has been reported in larger series. Goshtasbi et al reported higher regional metastases rates in patients with high-grade tumors (18.2%) compared with those 28 Similarly, the authors reported lower 5-year overall survival rates in high-grade (54.2%) versus low-grade tumors (80.2%). Despite Hyams histopathologic grading system being shown to have prognostic significance in some studies, our study likely fails to demonstrate a difference in regional control.…”

Section: Discussionmentioning

confidence: 91%

Regional Recurrences and Hyams Grade in Esthesioneuroblastoma

Ziai

Weinreb

et al. 2020

J Neurol Surg B Skull Base

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Objective The aim of this study is to determine if Hyams grade may help predict which patients with esthesioneuroblastoma (ENB) tumors are likely to develop regional recurrences, and to determine the impact of tumor extent on regional failure in ENB patients without evidence of nodal disease at presentation. Design The study was designed as a retrospective review for ENB patients. Settings The study was prepared at tertiary care academic center for ENB patients. Participants Patients with ENB were included in the study. Main Outcome Measures Oncologic outcomes (5-year regional and locoregional control (LRC) and overall survival) in patients with Hyams low grade versus high grade. Oncologic outcomes based on radiographic disease extent. Results A total of 43 patients were included. Total 25 patients (58%) had Hyams low-grade tumor, and 18 (42%) had high-grade tumor. Of the 34 patients without regional disease at presentation, 8 (24%) were treated with elective nodal radiation. There were no statistically significant differences in 5-year regional control in the Hyams low-grade versus high-grade groups (78 vs. 89%; p = 0.4). The 5-year LRC rates in patients with low grade versus high grade were 73 versus 89% (p = 0.6). The 5-year overall survival rates in patients with low-grade versus high-grade tumors were 86 versus 63% (p = 0.1). Radiographic extension of disease into the olfactory groove, olfactory nerve, dura, and periorbita were statistically associated with decreased 5-year overall survival (5-year OS 49 vs. 91% [p = 0.04], 49 vs. 91% [p = 0.04], 44 vs. 92% [p = 0.02], and 44 vs. 80% [p = 0.04], respectively). Conclusion ENBs are associated with a risk of regional failure. The current analysis suggests that Hyams low-grade and high-grade malignancies have comparable rates of early and delayed regional recurrences, although small sample size may limit our conclusions.

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Section: Discussionmentioning

confidence: 91%

Regional Recurrences and Hyams Grade in Esthesioneuroblastoma

Ziai

Weinreb

et al. 2020

J Neurol Surg B Skull Base

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“…The standard for pathological grading of ENB is the Hyams standard. At present, some studies have reported that pathological graded survival was significantly correlated and was an independent predictor of survival in patients with ENB [ 11 , 25 – 27 ]. For Chinese cohort, the tumor differentiation criterion based on the Hyams Grading System while the SEER cohort used the tumor differentiation grading scheme.…”

Section: Discussionmentioning

confidence: 99%

A novel nomogram to predict the overall survival in esthesinoeroblastoma

et al. 2020

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Background Increasing evidence indicates that the pathology and the modified Kadish system have some influence on the prognosis of esthesioneuroblastoma (ENB). However, an accurate system to combine pathology with a modified Kadish system has not been established. Methods This study aimed to set up and evaluate a model to predict overall survival (OS) accurately in ENB, including clinical characteristics, treatment and pathological variables. We screened the information of patients with ENB between January 1, 1976, and December 30, 2016 from the National Cancer Institute Surveillance, Epidemiology, and End Results (SEER) program as a training cohort. The validation cohort consisted of patients with ENB at Sun Yat-sen University Cancer Center and The First Affiliated Hospital of Sun Yat-sen University in the same period, and 87 patients were included. The Pearson’s chi-squared test was used to assess significance of clinicopathological and demographic characteristics. We used the Cox proportional hazards model to examine univariate and multivariate analyses. The model coefficients were used to calculate the Hazard ratios (HR) with 95% confidence intervals (CI). Prognostic factors with a p-value < 0.05 in multivariate analysis were included in the nomogram. The concordance index (c-index) and calibration curve were used to evaluate the predictive power of the nomogram. Results The c-index of training cohort and validation cohort are 0.737 (95% CI, 0.709 to 0.765) and 0.791 (95% CI, 0.767 to 0.815) respectively. The calibration curves revealed a good agreement between the nomogram prediction and actual observation regarding the probability of 3-year and 5-year survival. We used a nomogram to calculate the 3-year and 5-year growth probability and stratified patients into three risk groups. Conclusions The nomogram provided the risk group information and identified mortality risk and can serve as a reference for designing a reasonable follow-up plan.

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“…The standard for pathological grading of ENB is the Hyams standard. At present, some studies have reported that pathological graded survival was signi cantly correlated and was an independent predictor of survival in patients with ENB [19,[27][28][29]. For Chinese cohort, the tumor differentiation criterion based on the Hyams Grading System while the SEER cohort used the tumor differentiation grading scheme.…”

Section: Discussionmentioning

confidence: 99%

A novel nomogram to predict the overall survival in esthesinoeroblastoma

Jiang

Lin

Gao

et al. 2020

Preprint

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Background Increasing evidence indicates that the pathology and the modified Kadish system have some influence on the prognosis of esthesioneuroblastoma (ENB). However, an accurate system to combine pathology with a modified Kadish system has not been established. MethodsThis study aimed to set up and evaluate a model to predict overall survival (OS) accurately in ENB, including clinical characteristics, treatment and pathological variables. We screened the information of patients with ENB between January 1, 1976, and December 30, 2016 from the National Cancer Institute Surveillance, Epidemiology, and End Results (SEER) program as a training cohort. The validation cohort consisted of patients with ENB at Sun Yat-sen University Cancer Center and The First Affiliated Hospital of Sun Yat-sen University in the same period, and 87 patients were included. The Pearson’s chi-squared test was used to assess significance of clinicopathological and demographic characteristics. We used the Cox proportional hazards model to examine univariate and multivariate analyses. The model coefficients were used to calculate the Hazard ratios (HR) with 95% confidence intervals (CI). Prognostic factors with a p-value < 0.05 in multivariate analysis were included in the nomogram. The concordance index (c-index) and calibration curve were used to evaluate the predictive power of the nomogram.ResultsThe c-index of training cohort and validation cohort are 0.737 (95% CI, 0.709 to 0.765) and 0.791 (95% CI, 0.767 to 0.815) respectively. The calibration curves revealed a good agreement between the nomogram prediction and actual observation regarding the probability of 3-year and 5-year survival. We used a nomogram to calculate the 3-year and 5-year growth probability and stratified patients into three risk groups.ConclusionsThe nomogram provided the risk group information and identified mortality risk and can serve as a reference for designing a reasonable follow-up plan.

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Hyams grading as a predictor of metastasis and overall survival in esthesioneuroblastoma: a meta‐analysis

Cited by 55 publications

References 52 publications

Regional Recurrences and Hyams Grade in Esthesioneuroblastoma

Regional Recurrences and Hyams Grade in Esthesioneuroblastoma

A novel nomogram to predict the overall survival in esthesinoeroblastoma

A novel nomogram to predict the overall survival in esthesinoeroblastoma

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