The paper proposes a fault-tolerant tracking control scheme based on a robust observer for a descriptor system. Thus, it is assumed that the described system can be simultaneously occupied by an unknown input disturbance, along with an actuator and sensor faults. Additionally, it is natural to assume that the unknown input disturbance cannot be estimated, which makes the control process more difficult. Moreover, the proposed descriptor system is also occupied by external disturbances. Thus, the robust stability of the proposed control and estimation scheme was guaranteed by using H∞ performance. Consequently, the DC servo-motor laboratory system was used to confirm the correctness and effectiveness of the proposed fault-tolerant tracking control scheme.