Hybrid bacterial cellulose–pectin films for delivery of bioactive molecules

Cacicedo, Maximiliano L.; Islan, Germán Abel; Drachemberg, M. Florencia; Álvarez, Vera A.; Bartel, Laura C.; Bolzán, Alejandro D.; Castro, Guillermo R.

doi:10.1039/c7nj03973e

Cited by 46 publications

(21 citation statements)

References 47 publications

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“…Most dermal patches are prepared by simply soaking a pure BC membrane, or a BC‐based composite, in a solution of the compounds of interest. In order to achieve multiple desired results, these membranes can be loaded with more than one compound at once.…”

Section: Applicationsmentioning

confidence: 99%

“…Furthermore, the drug loading capacity and drug release rate were further controlled by the drying method of the membranes (freeze drying vs. oven drying). In another study, two different molecules were loaded in a BC‐based composite, specifically serum albumin, which modulated the release of the other molecule, levofloxacin, reducing its cytotoxicity to undetected levels, without losing its antibacterial activity. These three mentioned studies, are a great example of the versatility of BC to further develop dermal patches for drug delivery systems, that can be laden with different molecules while maintaining properties of interest.…”

Section: Applicationsmentioning

confidence: 99%

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Latest Advances on Bacterial Cellulose‐Based Materials for Wound Healing, Delivery Systems, and Tissue Engineering

Carvalho

Guedes

Sousa

et al. 2019

Biotechnology Journal

127

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Bacterial cellulose (BC) is a nanocellulose form produced by some nonpathogenic bacteria. BC presents unique physical, chemical, and biological properties that make it a very versatile material and has found application in several fields, namely in food industry, cosmetics, and biomedicine. This review overviews the latest state‐of‐the‐art usage of BC on three important areas of the biomedical field, namely delivery systems, wound dressing and healing materials, and tissue engineering for regenerative medicine. BC will be reviewed as a promising biopolymer for the design and development of innovative materials for the mentioned applications. Overall, BC is shown to be an effective and versatile carrier for delivery systems, a safe and multicustomizable patch or graft for wound dressing and healing applications, and a material that can be further tuned to better adjust for each tissue engineering application, by using different methods.

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Section: Applicationsmentioning

confidence: 99%

Section: Applicationsmentioning

confidence: 99%

Latest Advances on Bacterial Cellulose‐Based Materials for Wound Healing, Delivery Systems, and Tissue Engineering

Carvalho

Guedes

Sousa

et al. 2019

Biotechnology Journal

127

View full text Add to dashboard Cite

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“…an exopolysaccharide produced by some non-pathogenic bacteria, namely the acetic acid bacteria of the genus Komagataeibacter (formerly classified as Gluconacetobacter) [17,18], is gaining increasing attention in the biomedical realm [19][20][21], particularly as a wound-dressing material [19,22,23]. Hence, the current study was inspired not only by the biocompatibility, high water-retention capacity, nanostructured porous network and good in vivo skin compatibility of BNC [20,24], but also by the fact that this exopolysaccharide can be directly produced in the form of membranes or films with customizable size and shape, and can house an array of active molecules (e.g., lidocaine [25,26], diclofenac [27,28], amoxicillin [29] and levofloxacin [30]) and macromolecules (e.g., poly([2-(methacryloyloxy)ethyl]trimethylammonium chloride) [31] and vitamin B-based ionic liquids [32]) that confer new functionalities to the ensuing materials. Although (i) HA has already been added to the culture media during BNC biosynthesis, to obtain BNC/HA membranes with no specific application [33], and (ii) the combination between BNC and DCF has already been studied for transdermal delivery [27], the coalition of BNC with HA and DCF has not yet been studied, at least to the best of our knowledge, for the potential treatment of aphthous stomatitis.…”

Section: Introductionmentioning

confidence: 99%

Nanocellulose-Based Patches Loaded with Hyaluronic Acid and Diclofenac towards Aphthous Stomatitis Treatment

et al. 2020

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Nanostructured patches composed of bacterial nanocellulose (BNC), hyaluronic acid (HA) and diclofenac (DCF) were developed, envisioning the treatment of aphthous stomatitis. Freestanding patches were prepared via diffusion of aqueous solutions of HA and DCF, with different concentrations of DCF, into the wet BNC three-dimensional porous network. The resultant dual polysaccharides-based patches with a nanostructured morphology present thermal stability up to 200 °C, as well as good dynamic mechanical properties, with a storage modulus higher than 1.0 GPa. In addition, the patches are non-cytotoxic to human keratinocytes (HaCaT cells), with a cell viability of almost 100% after 24 h. The in vitro release profile of DCF from the patches was evaluated in simulated saliva, and the data refer to a diffusion- and swelling-controlled drug-release mechanism. The attained results hint at the possibility of using these dual polysaccharides-based oral mucosal patches to target aphthous stomatitis.

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“…For instance, neat BNC membranes have already been combined with drugs and other bioactive compounds, such as lidocaine [22,23], ibuprofen [23], caffeine [24], diclofenac [25] and amoxicillin [26] in their most common forms or formulated as ionic liquids [27,28] for cutaneous drug delivery. There are also examples of BNC-based nanocomposites being used for the cutaneous delivery of diclofenac [29] and BNC-based hybrid films for the cutaneous delivery of levofloxacin [30].…”

Section: Introductionmentioning

confidence: 99%

Topical Drug Delivery Systems Based on Bacterial Nanocellulose: Accelerated Stability Testing

Silva

Mota

Almeida

et al. 2020

IJMS

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Bacterial nanocellulose (BNC) membranes have enormous potential as systems for topical drug delivery due to their intrinsic biocompatibility and three-dimensional nanoporous structure, which can house all kinds of active pharmaceutical ingredients (APIs). Thus, the present study investigated the long-term storage stability of BNC membranes loaded with both hydrophilic and lipophilic APIs, namely, caffeine, lidocaine, ibuprofen and diclofenac. The storage stability was evaluated under accelerated testing conditions at different temperatures and relative humidity (RH), i.e., 75% RH/40 °C, 60% RH/25 °C and 0% RH/40 °C. All systems were quite stable under these storage conditions with no significant structural and morphological changes or variations in the drug release profile. The only difference observed was in the moisture-uptake, which increased with RH due to the hydrophilic nature of BNC. Furthermore, the caffeine-loaded BNC membrane was selected for in vivo cutaneous compatibility studies, where patches were applied in the volar forearm of twenty volunteers for 24 h. The cutaneous responses were assessed by non-invasive measurements and the tests revealed good compatibility for caffeine-loaded BNC membranes. These results highlight the good storage stability of the API-loaded BNC membranes and their cutaneous compatibility, which confirms the real potential of these dermal delivery systems.

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Hybrid bacterial cellulose–pectin films for delivery of bioactive molecules

Abstract: Novel biopolymeric films based on bacterial cellulose (BC) modified with high methoxylated pectin (HMP) were developed for drug delivery.

Cited by 46 publications

References 47 publications

Latest Advances on Bacterial Cellulose‐Based Materials for Wound Healing, Delivery Systems, and Tissue Engineering

Latest Advances on Bacterial Cellulose‐Based Materials for Wound Healing, Delivery Systems, and Tissue Engineering

Nanocellulose-Based Patches Loaded with Hyaluronic Acid and Diclofenac towards Aphthous Stomatitis Treatment

Topical Drug Delivery Systems Based on Bacterial Nanocellulose: Accelerated Stability Testing

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