Hybrid bio-nanoporous peptide loaded-polymer platforms with anticancer and antibacterial activities

Icriverzi, Madalina; Florian, Paula Ecaterina; Bonciu, Anca; Dumitrescu, Luminita Nicoleta; Moldovan, Antoniu; Pelinescu, Diana; Ionescu, Robertina; Avram, Ionela; Munteanu, Cristian V. A.; Sima, Livia Elena; Dinca, Valentina; Rusen, Laurentiu; Roseanu, Anca

doi:10.1039/d3na00947e

Nanoscale Adv.

2024

DOI: 10.1039/d3na00947e

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Hybrid bio-nanoporous peptide loaded-polymer platforms with anticancer and antibacterial activities

Madalina Icriverzi,

Paula Ecaterina Florian,

Anca Bonciu

et al.

Abstract: In this study, hybrid bio nano-porous peptides loaded onto poly (N-isopropylacrylamide-co-butylacrylate) (pNIPAM-co-BA) coatings were designed and obtained by Matrix assisted Pulsed Laser Evaporation (MAPLE) technique. The incorporation of cationic peptides...

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Macromolecular Poly(N‐isopropylacrylamide) (PNIPAM) in Cancer Treatment and Beyond

Throat,

Bhattacharya

2024

Advances in Polymer Technology

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Poly(N‐isopropylacrylamide) (PNIPAM) is a versatile polymer known for its phase transition properties, exhibiting a lower critical solution temperature (LCST) of approximately 32°C. Below this temperature, PNIPAM is hydrophilic, while above it, the polymer becomes hydrophobic, making it ideal for thermosensitive drug delivery systems (DDSs). In tissue engineering, PNIPAM provides a biocompatible, nontoxic and stimuli‐responsive surface for cell culture. Its nontoxic nature ensures safety in medical applications. PNIPAM enhances biosensing diagnostics through its affinity for biomolecules, improving accuracy. Widely used in hydrogels, smart textiles, soft robotics and various medical applications, PNIPAM adapts to environmental changes. Its straightforward synthesis allows for the creation of diverse copolymers and composites, applicable in selective reactions and conjugations with fluorescent tags or chemical modifications. PNIPAM’s versatility extends to pH‐responsive alternatives, broadening its application spectrum. Practical examples include phase separation in water treatment and cleaning processes. This discussion explores PNIPAM’s biomedical and drug delivery applications, particularly in cancer treatment, photothermal therapy (PTT) and photodynamic therapy (PDT), gene delivery and medical imaging. Additionally, it highlights PNIPAM’s noncancerous applications, such as small interfering RNA (siRNA) targeting of oncogenes and detailed imaging of deep and tumour tissues.

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Macromolecular Poly(N‐isopropylacrylamide) (PNIPAM) in Cancer Treatment and Beyond

Throat,

Bhattacharya

2024

Advances in Polymer Technology

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Hybrid bio-nanoporous peptide loaded-polymer platforms with anticancer and antibacterial activities

Abstract: In this study, hybrid bio nano-porous peptides loaded onto poly (N-isopropylacrylamide-co-butylacrylate) (pNIPAM-co-BA) coatings were designed and obtained by Matrix assisted Pulsed Laser Evaporation (MAPLE) technique. The incorporation of cationic peptides...

Cited by 1 publication

References 90 publications

Macromolecular Poly(N‐isopropylacrylamide) (PNIPAM) in Cancer Treatment and Beyond

Macromolecular Poly(N‐isopropylacrylamide) (PNIPAM) in Cancer Treatment and Beyond

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