Hybrid Bioelastomer Reinforced by Ultrathin Nanowires of Lanthanide Hydroxycarbonates for Promising Biomedical Applications

Abstract

Hybrids composed of biocompatible polymers reinforced with inorganic nanomaterials are useful for many biomedical applications including implantation and tissue regeneration and engineering. In this work, we report a new type of hybrid prepared by doping ultrathin nanowires of lanthanide hydroxycarbonates into classical biocompatible poly(citrates-siloxane). The doping of the inorganic nanowires imparts the hybrids with excellent miscibility with the polymeric matrix, producing hybrids with high elasticity and high tensile strength. The hybrids containing Eu(III) and Gd(III) display their respective luminescence and magnetic properties and thus, offer opportunities to monitor the fate of such hybrids when used in vivo. Insignificant degradation and excellent biocompatibility of these hybrids have also been demonstrated. Together, these favorable traits portend useful applications of the newly developed hybrid elastomers.

A comprehensive review on the biomedical frontiers of nanowire applications

“…Efficient delivery and controlled release of therapeutic agents or biosensors are essential for nanowires' use [ [88] , [89] , [90] ]. Further research is needed to investigate the stability and degradation of nanowires in physiological conditions [ [91] , [92] , [93] ]. Surface functionalization is crucial for biomedical applications, however it may be complex [ 94 , 95 ].…”