Hybrid cardiac imaging: Complementary roles of CT angiography and PET in a patient with a history of radiation therapy

Hong, Eric; Kimura‐Hayama, Eric; Carli, Marcelo F. Di

doi:10.1016/j.nuclcard.2007.05.002

Cited by 4 publications

(4 citation statements)

References 9 publications

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“…An interesting case report by Letsas et al 25 described a patient who experienced an acute myocardial infarction in the setting of normal coronary arteries 16 years after irradiation of the chest for the treatment of Hodgkin disease. Additionally, a recent case report by Hong et al 9 described a patient with lymphoma who had a myocardial perfusion abnormality as detected using positron emission tomography but normal coronary arteries on a coronary CT angiogram. We have observed during this study and our previous study of patients with esophageal cancer sharp geometric demarcation between abnormal and normal myocardium in relation to the higher radiation isodose lines of 40 to 45 Gy.…”

Section: Discussionmentioning

confidence: 99%

“…However, investigators have demonstrated the early effects of RT using multiple imaging modalities. [7][8][9] For example, studies have found myocardial perfusion abnormalities using myocardial perfusion imaging (MPI) early after RT and even before the development of clinical symptoms. 10 -14 The number of patients with such perfusion abnormalities usually increases as the interval after RT increases.…”

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confidence: 99%

See 1 more Smart Citation

Patterns of Cardiac Perfusion Abnormalities After Chemoradiotherapy in Patients with Lung Cancer

Gayed

Liu²,

Xiong³

et al. 2009

Journal of Thoracic Oncology

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Patterns of Cardiac Perfusion Abnormalities After Chemoradiotherapy in Patients with Lung Cancer

Gayed

Liu²,

Xiong³

et al. 2009

Journal of Thoracic Oncology

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“…This is underlined by the fact that Ge-68 sources used in the previous generation of PET scanners provided the same information, but such type of imaging was not perceived as hybrid imaging as attenuation correction does not contribute to topographic image information. Others have used the term "hybrid imaging" for the side-by-side analysis of MPI and CT 6 images (30). To avoid confusion we suggest using the term hybrid imaging for any combination of structural and functional information beyond that offered by attenuation correction or side-by-side analysis, i.e.…”

Section: Definition and General Aspects Of Hybrid Imagingmentioning

confidence: 99%

Cardiac hybrid imaging: state-of-the-art

Kaufmann

2009

Ann Nucl Med

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“…7,8 Others used the term "hybrid imaging" for the mere side-by-side analysis of MPI and CT images. 9 To avoid confusion, we suggest the use of "hybrid imaging" to describe any combination of structural and functional information beyond that offered by attenuation correction or side-byside analysis, by fusion of the separate data sets into one image ( Figure 1). Thus, this definition would not include attenuation-corrected images without integrating anatomical information.…”

Section: What Is Cardiac Hybrid Imaging?mentioning

confidence: 99%

Hybrid cardiac imaging: More than the sum of its parts?

Gaemperli

Kaufmann

2008

Journal of Nuclear Cardiology

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The constant technological developments in noninvasive cardiac imaging over the past few decades have contributed toward our pathophysiologic understanding of many conditions. Particularly in coronary artery disease (CAD), management is based on the assessment of both the presence of coronary stenoses and their hemodynamic consequences. 1,2 Hence, noninvasive imaging helps guide therapeutic decisions by providing complementary information on coronary morphology and on myocardial perfusion and metabolism, using several imaging tools. 3,4 This imaging includes nuclear techniques such as single-photon emission computed tomography (SPECT) or positron emission tomography (PET), computed tomography (CT) techniques such as electron-beam CT (EBCT) or multislice CT (MSCT), and cardiac magnetic resonance (CMR).Advances in image-processing software and the advent of hybrid scanners have paved the way for the fusion of image datasets from different modalities, giving rise to multimodality or hybrid imaging. This technology avoids the mental integration of functional and morphologic images, and facilitates a comprehensive interpretation of combined datasets. The interest in hybrid imaging has rapidly spread to cardiac applications, and has changed the landscape of noninvasive cardiac imaging by bringing different clinical specialties (eg, cardiology, radiology, and nuclear medicine) closer together. 5 In addition, this interest has driven the development and production of dedicated hybrid scanners in an effort to simplify image coregistration and improve patient throughput for specialized cardiac imaging centers (ie, hardware-based image coregistration). However, given the high costs associated with such devices, an attractive alternative for hybrid imaging consists of the "offline," software-based fusion of images obtained from nondedicated standalone scanners (software-based image coregistration). Here, we focus on comparing hardwarebased versus software-based image coregistration for car-diac hybrid imaging and their respective advantages and drawbacks. WHAT IS CARDIAC HYBRID IMAGING?The hallmark of hybrid imaging is the combined or fused imaging of two datasets, where both modalities contribute equally to image information. However, the term "hybrid imaging" has been used in other contexts, raising confusion about its exact meaning.Some authors have referred to the X-ray-based attenuation correction of myocardial perfusion imaging (MPI) as hybrid imaging. 6 However, in such a setting, CT images do not provide added anatomical or functional information, but are used merely to improve the image quality of the other modality (ie, PET or SPECT). In fact, whereas attenuation correction by 68 Germanium sources, as used in the previous generation of PET scanners, provided the same information, such imaging was not perceived as hybrid, probably because attenuation correction does not contribute to topographic image information. Similarly, the parametric maps obtained from low-dose CT do not provide image information beyond that n...

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Hybrid cardiac imaging: Complementary roles of CT angiography and PET in a patient with a history of radiation therapy

Cited by 4 publications

References 9 publications

Patterns of Cardiac Perfusion Abnormalities After Chemoradiotherapy in Patients with Lung Cancer

Patterns of Cardiac Perfusion Abnormalities After Chemoradiotherapy in Patients with Lung Cancer

Cardiac hybrid imaging: state-of-the-art

Hybrid cardiac imaging: More than the sum of its parts?

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