Hybrid Conducting Polymer–Hydrogel Conduits for Axonal Growth and Neural Tissue Engineering

Abidian, Mohammad Reza; Daneshvar, Eugene D.; Egeland, Brent M.; Kipke, Daryl R.; Cederna, Paul S.; Urbanchek, Melanie G.

doi:10.1002/adhm.201200182

Cited by 128 publications

(91 citation statements)

References 71 publications

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“…Scaffolds electrodeposited with PEDOT increase axon growth in nerve conduits [5]. Hybrid macroporous hydrogels made of PANI and poly(ethylene glycol) diacrylate improve the differentiation of PC-12 and human mesenchymal stem cells [6].…”

Section: Introductionmentioning

confidence: 99%

Protocol and cell responses in three-dimensional conductive collagen gel scaffolds with conductive polymer nanofibres for tissue regeneration

2014

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It has been established that nerves and skeletal muscles respond and communicate via electrical signals. In regenerative medicine, there is current emphasis on using conductive nanomaterials to enhance electrical conduction through tissue-engineered scaffolds to increase cell differentiation and tissue regeneration. We investigated the role of chemically synthesized polyaniline (PANI) and poly(3,4-ethylenedioxythiophene) (PEDOT) conductive polymer nanofibres for conductive gels. To mimic a naturally derived extracellular matrix for cell growth, type I collagen gels were reconstituted with conductive polymer nanofibres and cells. Cell viability and proliferation of PC-12 cells and human skeletal muscle cells on these three-dimensional conductive collagen gels were evaluated in vitro. PANI and PEDOT nanofibres were found to be cytocompatible with both cell types and the best results (i.e. cell growth and gel electrical conductivity) were obtained with a low concentration (0.5 wt%) of PANI. After 7 days of culture in the conductive gels, the densities of both cell types were similar and comparable to collagen positive controls. Moreover, PC-12 cells were found to differentiate in the conductive hydrogels without the addition of nerve growth factor or electrical stimulation better than collagen control. Importantly, electrical conductivity of the three-dimensional gel scaffolds increased by more than 400% compared with control. The increased conductivity and injectability of the cell-laden collagen gels to injury sites in order to create an electrically conductive extracellular matrix makes these biomaterials very conducive for the regeneration of tissues.

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Section: Introductionmentioning

confidence: 99%

Protocol and cell responses in three-dimensional conductive collagen gel scaffolds with conductive polymer nanofibres for tissue regeneration

2014

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“…As the most studied conductive polymer, PPy has been synthesized by chemical oxidation using a radical initiator with an appropriate electrolyte solution [59,60] or by electrochemical oxidation of pyrrole with an electrolyte solution on a platinum-coated electrode [61]. PPy has been reported to offer focal adhesion and the growth of various cell types associated with endothelial cells [62,63], neurons, supporting cells (DRG) [64][65][66], and rat pheochromocytoma (PC12) cells [66][67][68][69]. Yang et al devised conductive hydrogels of hyaluronic acid and PPy that enhanced mechanical and conductive properties [70] (Figure 4).…”

Section: Conductive Polymersmentioning

confidence: 99%

Incorporation of Conductive Materials into Hydrogels for Tissue Engineering Applications

Min¹,

Koh²

2018

Preprint

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In the field of tissue engineering, conductive hydrogels have been the most effective biomaterials to mimic the biological and electrical properties of tissues in the human body. The main advantages of conductive hydrogel include not only its physical properties, but also its adequate electrical properties, thus providing electrical signals to cells efficiently. However, when introducing a conductive material into a non-conductive hydrogel, a conflicting relationship between the electrical and mechanical properties may develop. This review examines the strengths and weaknesses of the generation of conductive hydrogels using various conductive materials and introduces the use of these conductive hydrogels in tissue engineering applications.

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“…Meanwhile, conducting polymers with good biocompatibility is widely applied in biomedical area such as biomedical imaging [45], biosensor [46,47], artificial muscle [48], drug release controller [49], cancer biomarker [50] and neural interface [51,52]. One of the most important roles conducting polymer plays is in the electrode-tissue interface material for neural engineering, as it can be facilely fabricated into multiple structures [53], modified by different doping [54,55] and regulated to undertake electrical stimulation [56,57].…”

Section: Electrode-tissue Interface For Neural Interfacementioning

confidence: 99%

Progress in Research of Flexible MEMS Microelectrodes for Neural Interface

Tang¹,

Tian²,

Kang³

et al. 2017

Preprint

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Abstract:With the rapid development of MEMS (Micro-electro-mechanical Systems) fabrication technologies, manifolds microelectrodes with various structures and functions have been designed and fabricated for applications in biomedical research, diagnosis and treatment through electrical stimulation and electrophysiological signal recording. The flexible MEMS microelectrodes exhibit multi-aspect excellent characteristics beyond stiff microelectrodes based on silicon or SU-8, which comprising: lighter weight, smaller volume, better conforming to neural tissue and lower fabrication cost. In this paper, we mainly reviewed key technologies on flexible MEMS microelectrodes for neural interface in recent years, including: design and fabrication technology, flexible MEMS microelectrodes with fluidic channels and electrode-tissue interface modification technology for performance improvement. Furthermore, the future directions of flexible MEMS microelectrodes for neural interface were described including transparent and stretchable microelectrodes integrated with multi-aspect functions and next-generation electrode-tissue interface modifications facilitated electrode efficacy and safety during implantation. Finally, the combinations among micro fabrication techniques with biomedical engineering and nanotechnology represented by flexible MEMS microelectrodes for neural interface will open a new gate to human lives and understanding of the world.

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Hybrid Conducting Polymer–Hydrogel Conduits for Axonal Growth and Neural Tissue Engineering

Cited by 128 publications

References 71 publications

Protocol and cell responses in three-dimensional conductive collagen gel scaffolds with conductive polymer nanofibres for tissue regeneration

Protocol and cell responses in three-dimensional conductive collagen gel scaffolds with conductive polymer nanofibres for tissue regeneration

Incorporation of Conductive Materials into Hydrogels for Tissue Engineering Applications

Progress in Research of Flexible MEMS Microelectrodes for Neural Interface

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