Hybrid Dextran-gadolinium Nano-suitcases as High-relaxivity MRI Contrast Agents

Wang, Hao; Dai, Tingting; Lu, Bolun; Li, Shengli; Lü, Qing; Mukwaya, Vincent; Dou, Hongjing

doi:10.1007/s10118-018-2083-1

Cited by 16 publications

(19 citation statements)

References 37 publications

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“…Future PISA methods, with alternative polymerization approaches, will likely allow the efficient preparation of functional nanoparticles (or nanomedicines) that are currently only accessible via the less efficient solvent switch method. For example, efficient synthesis is beneficial for nanoparticles used in antibacterial products, 79,138 treatment of diabetes, [139][140][141][142] drug delivery, [143][144][145][146] magnetic resonance imaging (MRI), 145,[147][148][149] and so forth. New delicate methods to accurately target desired morphologies during PISA are desired to fully utilize the potential of this powerful technique.…”

Section: Conclusion/perspectivementioning

confidence: 99%

Principles and Characteristics of Polymerization-Induced Self-Assembly with Various Polymerization Techniques

et al. 2021

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Section: Conclusion/perspectivementioning

confidence: 99%

Principles and Characteristics of Polymerization-Induced Self-Assembly with Various Polymerization Techniques

et al. 2021

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“…Owing to the rapid progression of nanotechnology, new antithrombotic nanotherapeutics have sprung up in recent years. The nanoscale characteristics of nanocarriers can introduce unique physical and chemical properties, and extend the circulation time of drugs in the bloodstream ( Wang et al, 2018a ; Zhang et al, 2018 ). Moreover, the long-chain structure of polymer macromolecules also facilitates the modification of these platforms for targeting capability and enables researchers to design nanocarriers and impart them with specific functions in order to meet a given requirement ( Guo et al, 2018 ; Wang et al, 2018b ; Shakiba et al, 2021 ).…”

Section: Targeted Chemical Modification Of Nanocarriers and Applicationsmentioning

confidence: 99%

Thrombus-Targeting Polymeric Nanocarriers and Their Biomedical Applications in Thrombolytic Therapy

Guan

Dou

2021

Front. Physiol.

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Due to the high morbidity and mortality of cardiovascular diseases, there is an urgent need for research on antithrombotic strategies. In view of the short half-life, insufficient drug penetration, poor targeting capabilities, and hemorrhagic side-effects of traditional thrombus treatment methods, the combination of thrombolytic therapy and nanocarriers brought by the development of nanotechnology in recent years may provide effective solutions for these undesirable side-effects caused by insufficient targeting. Polymeric nanocarriers, based on macromolecules and various functional groups, can connect specific targeting molecules together through chemical modification to achieve the protection and targeted delivery of thrombolytic drugs. However, simple chemical molecular modifications may be easily affected by the physiological environment encountered in the circulatory system. Therefore, the modification of nanocarriers with cell membranes can provide camouflage to these platforms and help to extend their circulation time while also imparting them with the biological functions of cell membranes, thus providing them with precise targeting capabilities, among which the most important is the biological modification of platelet membranes. In addition, some nanoparticles with their own therapeutic functions have also been developed, such as polypyrrole, which can exhibit a photothermal effect to induce thrombolysis. Herein, combined with the mechanism of thrombosis and thrombolysis, we outline the recent advances achieved with thrombus-targeting nanocarriers with regard to thrombosis treatment. On this basis, the design considerations, advantages, and challenges of these thrombolytic therapies in clinical transformation are discussed.

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“…In the same year, Dou et al synthesized dextran-poly(glycidyl methacrylate) (Dex-PGMA) nanosuitcases via a gra copolymerization induced self-assembly (GISA) approach. 92 Then, these nano-suitcases were modied with hydrazine groups in order to afford non-covalent interactions between the hydrazine group and the carboxylic groups of Gd-DTPA. The amount of the Gd-complex in the nano-suitcases, estimated using inductively coupled plasma atomic emission spectroscopy (ICP-AES), was 22.6% wt.…”

Section: Covalently Bound Gd Complexesmentioning

confidence: 99%

Systematic overview of soft materials as a novel frontier for MRI contrast agents

et al. 2020

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Hybrid Dextran-gadolinium Nano-suitcases as High-relaxivity MRI Contrast Agents

Cited by 16 publications

References 37 publications

Principles and Characteristics of Polymerization-Induced Self-Assembly with Various Polymerization Techniques

Principles and Characteristics of Polymerization-Induced Self-Assembly with Various Polymerization Techniques

Thrombus-Targeting Polymeric Nanocarriers and Their Biomedical Applications in Thrombolytic Therapy

Systematic overview of soft materials as a novel frontier for MRI contrast agents

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