Epidemic spreading phenomena are ubiquitous in nature and society. Examples include
the spreading of diseases, information, and computer viruses. Epidemics can spread
by local spreading, where infected nodes can only infect a limited set of
direct target nodes and global spreading, where an infected node can infect
every other node. In reality, many epidemics spread using a hybrid mixture of both
types of spreading. In this study we develop a theoretical framework for studying
hybrid epidemics, and examine the optimum balance between spreading mechanisms in
terms of achieving the maximum outbreak size. We show the existence of
critically hybrid epidemics where neither spreading mechanism alone can
cause a noticeable spread but a combination of the two spreading mechanisms would
produce an enormous outbreak. Our results provide new strategies for maximising
beneficial epidemics and estimating the worst outcome of damaging hybrid
epidemics.