Hybrid gelatin-sulfated alginate scaffolds as dermal substitutes can dramatically accelerate healing of full-thickness diabetic wounds

Sadeghi, Ali; Zare-Gachi, Maryam; Najjar-Asl, Mostafa; Rajabi, Sarah; Fatemi, Mohammad Javad; Forghani, Siamak Farokh; Daemi, Hamed; Pezeshki‐Modaress, Mohamad

doi:10.1016/j.carbpol.2022.120404

Cited by 20 publications

(7 citation statements)

References 40 publications

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“…For example, a hybrid scaffold of gelatin and sulfated alginate was shown to accelerate diabetic wound repair with the increase in sulfated alginate content. [ 224 ] The results indicated that the gelatin/sulfated alginate scaffold promoted collagen synthesis, higher blood vessel formation, reduced inflammation, and a higher epidermal reformation rate compared to gelatin‐only scaffolds.…”

Section: Natural Polymers For Skin Repair and Regeneration: Polysacch...mentioning

confidence: 99%

Natural Polymer‐Based Materials for Wound Healing Applications

Ho,

Tran,

Doan

et al. 2024

Advanced NanoBiomed Research

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Skin injuries pose significant health challenges, with conditions like burns and diabetic, venous, and pressure ulcers presenting complex wound management scenarios. Effective wound care strategies for these injuries encompass a range of interventions, from simple wound dressings to bioactive materials and surgical procedures involving skin substitutes and skin grafting. This review explores the potential of natural polymers, including silk, collagen, gelatin, elastin, cellulose, chitosan, alginate, and hyaluronic acid, in wound management. Natural polymers offer several advantages, including abundance, biodegradability, and compatibility with traditional and modern material fabrication techniques, and have demonstrated safety and efficacy in clinical applications, modulating various facets of the wound healing process. Highlighting preclinical and clinical studies, along with commercial products, this review showcases the versatility and utility of natural polymers in wound management and provides insights into emerging developments, such as 3D bioprinting and stimuli‐responsive materials, which hold promise for personalized wound treatments. Additionally, we discuss the importance of the material format and morphology in engineering the next generation of wound dressings and skin substitutes, offering a pathway to optimize natural polymers for enhanced wound healing outcomes.

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Section: Natural Polymers For Skin Repair and Regeneration: Polysacch...mentioning

confidence: 99%

Natural Polymer‐Based Materials for Wound Healing Applications

Ho,

Tran,

Doan

et al. 2024

Advanced NanoBiomed Research

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“…In this study, human umbilical vein endothelial cells were embedded into the scaffolds and the network formed by the hollow fibers supplied the oxygen and required nutrients and aided the waste removal (Li et al, 2020). Sadeghi et al (2023) developed a gelatine/alginate sulfate hybrid scaffold as a dermal substitute to hasten the healing of full-thickness diabetic ulcers in a diabetic mouse model. The scaffolds revealed no cytotoxicity, as well as, an increase in cell growth.…”

Section: Gelatinementioning

confidence: 99%

Polymeric biomaterials for wound healing

Oliveira¹,

Sousa²,

Teixeira³

et al. 2023

Front. Bioeng. Biotechnol.

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Skin indicates a person’s state of health and is so important that it influences a person’s emotional and psychological behavior. In this context, the effective treatment of wounds is a major concern, since several conventional wound healing materials have not been able to provide adequate healing, often leading to scar formation. Hence, the development of innovative biomaterials for wound healing is essential. Natural and synthetic polymers are used extensively for wound dressings and scaffold production. Both natural and synthetic polymers have beneficial properties and limitations, so they are often used in combination to overcome overcome their individual limitations. The use of different polymers in the production of biomaterials has proven to be a promising alternative for the treatment of wounds, as their capacity to accelerate the healing process has been demonstrated in many studies. Thus, this work focuses on describing several currently commercially available solutions used for the management of skin wounds, such as polymeric biomaterials for skin substitutes. New directions, strategies, and innovative technologies for the design of polymeric biomaterials are also addressed, providing solutions for deep burns, personalized care and faster healing.

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“…Wound healing involves the repair of damaged epidermis or dermis of the skin, for which multifunctional hydrogel dressings and skin substitutes have been extensively studied [25,26]. However, these approaches have limitations such as slow wound healing, immune rejection, and low mechanical strength.…”

Section: The Role Of Exosomes For Wound Healingmentioning

confidence: 99%

Current Strategies for Exosome Cargo Loading and Targeting Delivery

Zeng

Guo

Ren

et al. 2023

Cells

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Extracellular vesicles (EVs) such as ectosomes and exosomes have gained attention as promising natural carriers for drug delivery. Exosomes, which range from 30 to 100 nm in diameter, possess a lipid bilayer and are secreted by various cells. Due to their high biocompatibility, stability, and low immunogenicity, exosomes are favored as cargo carriers. The lipid bilayer membrane of exosomes also offers protection against cargo degradation, making them a desirable candidate for drug delivery. However, loading cargo into exosomes remains to be a challenge. Despite various strategies such as incubation, electroporation, sonication, extrusion, freeze–thaw cycling, and transfection that have been developed to facilitate cargo loading, inadequate efficiency still persists. This review offers an overview of current cargo delivery strategies using exosomes and summarizes recent approaches for loading small-molecule, nucleic acid, and protein drugs into exosomes. With insights from these studies, we provide ideas for more efficient and effective delivery of drug molecules by using exosomes.

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Hybrid gelatin-sulfated alginate scaffolds as dermal substitutes can dramatically accelerate healing of full-thickness diabetic wounds

Cited by 20 publications

References 40 publications

Natural Polymer‐Based Materials for Wound Healing Applications

Natural Polymer‐Based Materials for Wound Healing Applications

Polymeric biomaterials for wound healing

Current Strategies for Exosome Cargo Loading and Targeting Delivery

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