2024
DOI: 10.1021/acs.biomac.4c01162
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Hybrid Hydrogels of Polyacrylamide and Self-assembly Photodynamic Nanoparticles with Diverse Adhesion for Infected Chronic Wound Healing

Tianmeng Kang,
Zhaoyuan Guo,
Yao Lu
et al.

Abstract: The healing of infected wounds is challenging for patients. In this paper, a hybrid hydrogel with strong tissue adhesion, self-healing, and antibiosis without antibiotics was developed as a dressing to promote the healing of infected chronic wounds. Acrylamide (PAM) was polymerized with N,N-methylene bis(acrylamide) (BIS) as the substrate, and self-assembled nanoparticles of carboxymethyl chitosan and chlorin e6 (CMCS/ Ce6 NPs) trapped with magnesium (Mg 2+ ) ions were dispersed in the hydrogel substrate. CMCS… Show more

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