Hybrid land use regression modeling for estimating spatio-temporal exposures to PM2.5, BC, and metal components across a metropolitan area of complex terrain and industrial sources

Tripathy, Sheila; Tunno, Brett; Michanowicz, Drew R.; Kinnee, Ellen; Shmool, Jessie L.C.; Gillooly, Sara; Clougherty, Jane E.

doi:10.1016/j.scitotenv.2019.03.453

Cited by 44 publications

(25 citation statements)

References 38 publications

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“…Our approach toward PM 2.5 quantification is well detailed elsewhere. 28 In brief, we conducted a spatial-saturation monitoring campaign at 37 distinct sites during summer (June to July 2012) and winter (January to March 2013) across a region of approximately 388 km 2 . At each site, integrated PM 2.5 samples were collected using Harvard Impactors (Air Diagnostics and Engineering Inc), mounted at 10 to 12 ft, operated at a flow rate of 4.01 L/min, for the first 15 minutes of each hour per season during a 7-day sampling period.…”

Section: Methodsmentioning

confidence: 99%

“…A land use regression (LUR) modeling approach was used to model PM 2.5 concentrations as a function of GIS-based indicators of pollution sources and land use characteristics (eg, traffic density; transportation networks; roadway; industrial emissions; population; and truck, bus, and diesel indicators), accounting for temporal variation using concentrations at a reference monitoring site. 28 , 29 Using the LUR models, we created a continuous spatial surface of estimated PM 2.5 and used that surface to estimate 1-year mean exposures within the 300-m buffer that surrounded each participant’s home. 29 , 30 Earlier work 31 has demonstrated stable spatial variance in PM 2.5 concentrations, with the same areas remaining relatively high or low for years.…”

Section: Methodsmentioning

confidence: 99%

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Association of Fine Particulate Matter and Risk of Stroke in Patients With Atrial Fibrillation

et al. 2020

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Key Points Question What is the association between fine particulate matter measuring 2.5 μm or less (PM 2.5 ) air pollution and ischemic stroke in individuals with prevalent atrial fibrillation (AF)? Findings This cohort study including 31 414 individuals with AF found an association between PM 2.5 and prospective ischemic stroke risk in longitudinal, residential-level assessments in a large health care system situated in a region with high industrial activity. In multivariable-adjusted analyses that included relevant covariates and neighborhood-level income and educational level, individuals in the highest quartile of PM 2.5 exposure had a 1.2-fold higher risk of stroke compared with the lowest quartile. Meaning The association between residential-level pollution and stroke risk in the presence of AF appears to be an additional public health toll of pollution and suggests that stroke risk assessment in individuals with AF take into account the contributions of environmental exposures.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Association of Fine Particulate Matter and Risk of Stroke in Patients With Atrial Fibrillation

et al. 2020

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“…Air pollution, especially particular matter, is associated with worsening of lung function. The surface of particular matter is rich of metals such as iron, copper, zinc, manganese, and other transition elements, as well as polycyclic aromatic hydrocarbons (PAH), which are able to increase free radical production in the lung, consume antioxidant ingredients, and cause oxidative stress [89]. As such, these particulate substances are able to affect microbial composition and lead to a decrease of the relative abundance of Bacteroidetes and Fusobacteria alongside with an increase in the relative abundance of Firmicutes, Proteobacteria, and Actinobacteria in the oropharyngeal mucosa [90].…”

Section: Ii) Influence Of Pollen Allergens and Pollutants On Airwaymentioning

confidence: 99%

Dysbiosis of the gut and lung microbiome has a role in asthma

et al. 2020

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Worldwide 300 million children and adults are affected by asthma. The development of asthma is influenced by environmental and other exogenous factors synergizing with genetic predisposition, and shaping the lung microbiome especially during birth and in very early life. The healthy lung microbial composition is characterized by a prevalence of bacteria belonging to the phyla Bacteroidetes, Actinobacteria, and Firmicutes. However, viral respiratory infections are associated with an abundance of Proteobacteria with genera Haemophilus and Moraxella in young children and adult asthmatics. This dysbiosis supports the activation of inflammatory pathways and contributes to bronchoconstriction and bronchial hyperresponsiveness. Exogenous factors can affect the natural lung microbiota composition positively (farming environment) or negatively (allergens, air pollutants). It is evident that also gut microbiota dysbiosis has a high influence on asthma pathogenesis. Antibiotics, antiulcer medications, and other drugs severely impair gut as well as lung microbiota. Resulting dysbiosis and reduced microbial diversity dysregulate the bidirectional crosstalk across the gut-lung axis, resulting in hypersensitivity and hyperreactivity to respiratory and food allergens. Efforts are undertaken to reconstitute the microbiota and immune balance by probiotics and engineered bacteria, but results from human studies do not yet support their efficacy in asthma prevention or treatment. Overall, dysbiosis of gut and lung seem to be critical causes of the increased emergence of asthma.

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“…In the current study, we examined associations between annual average residence-based exposures to ambient PM 2:5 , black carbon (BC), and metal components, with circulating and stimulated levels of proinflammatory mediators among healthy middleaged adults in the Adult Health and Behavior project phase II (AHAB-II) cohort. To do so, we used hybrid-dispersion land use regression (LUR) models that we previously developed in Pittsburgh, Pennsylvania, to assess elevated concentrations of airborne metals related to steel emissions-lead (Pb), manganese (Mn), iron (Fe), and zinc (Zn)-across the urban area (Tripathy et al 2019). Based on the existing evidence, we hypothesized that elevated exposures to PM 2:5 , BC, Pb, Mn, Zn, and Fe would be associated with an increased inflammatory response to LPS, as indicated by LPS-stimulated production of cytokines .…”

Section: Introductionmentioning

confidence: 99%

Long-Term Ambient Air Pollution Exposures and Circulating and Stimulated Inflammatory Mediators in a Cohort of Midlife Adults

Tripathy

Marsland

Kinnee

et al. 2021

Environ Health Perspect

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BACKGROUND: Chronic exposure to air pollution may prime the immune system to be reactive, increasing inflammatory responses to immune stimulation and providing a pathway to increased risk for inflammatory diseases, including asthma and cardiovascular disease. Although long-term exposure to ambient air pollution has been associated with increased circulating markers of inflammation, it is unknown whether it also relates to the magnitude of inflammatory response. OBJECTIVES: The aim of this study was to examine associations between chronic ambient pollution exposures and circulating and stimulated levels of inflammatory mediators in a cohort of healthy adults. METHODS: Circulating interleukin (IL)-6, C-reactive protein (CRP) (n = 392), and lipopolysaccharide stimulated production of IL-1b, IL-6, and tumor necrosis factor ðTNFÞ-a (n = 379) were measured in the Adult Health and Behavior II cohort. Fine particulate matter [particulate matter with aerodynamic diameter less than or equal to 2.5 μm (PM 2:5 )] and constituents [black carbon (BC), and lead (Pb), manganese (Mn), zinc (Zn), and iron (Fe)] were estimated for each residential address using hybrid dispersion land use regression models. Associations between pollutant exposures and inflammatory measures were examined using linear regression; models were adjusted for age, sex, race, education, smoking, body mass index, and month of blood draw. RESULTS: There were no significant correlations between circulating and stimulated measures of inflammation. Significant positive associations were found between exposure to PM 2:5 and BC with stimulated production of IL-6, IL-1b, and TNF-a. Pb, Mn, Fe, and Zn exposures were positively associated with stimulated production of IL-1b and TNF-a. No pollutants were associated with circulating IL-6 or CRP levels. DISCUSSION: Exposure to PM 2:5 , BC, Pb, Mn, Fe, and Zn was associated with increased production of inflammatory mediators by stimulated immune cells. In contrast, pollutant exposure was not related to circulating markers of inflammation. These results suggest that chronic exposure to some pollutants may prime immune cells to mount larger inflammatory responses, possibly contributing to increased risk for inflammatory disease.

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Hybrid land use regression modeling for estimating spatio-temporal exposures to PM2.5, BC, and metal components across a metropolitan area of complex terrain and industrial sources

Cited by 44 publications

References 38 publications

Association of Fine Particulate Matter and Risk of Stroke in Patients With Atrial Fibrillation

Association of Fine Particulate Matter and Risk of Stroke in Patients With Atrial Fibrillation

Dysbiosis of the gut and lung microbiome has a role in asthma

Long-Term Ambient Air Pollution Exposures and Circulating and Stimulated Inflammatory Mediators in a Cohort of Midlife Adults

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