Hybrid liposomes composed of hydrophilic emulsifiers and lecithin: Physicochemical, interaction and curcumin loading properties

Li, Junhua; Chang, Cuihua; Chen, Wanying; Su, Yujie; Gu, Luping; Yang, Yanjun; Zhai, Jiali

doi:10.1016/j.colsurfa.2022.130210

Cited by 10 publications

(4 citation statements)

References 33 publications

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Section: Resultsmentioning

confidence: 99%

“…When no PG was added, the vesicle solution appeared to be white. As the proportion of PG increased, the vesicle solution exhibited enhanced transparency and displayed a characteristic blue emulsion phenomenon [28]. The particle size of PGEs ranged from 345.25 ± 8.25 nm (EtOH:PG = 10:0) to 212.54 ± 6.19 nm (EtOH:PG = 0:10), as indicated in Table 1.…”

Section: Characterization Of Ethosomesmentioning

confidence: 92%

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Designed Fabrication of Phloretin-Loaded Propylene Glycol Binary Ethosomes: Stability, Skin Permeability and Antioxidant Activity

Zhang,

Zhuang,

et al. 2023

Molecules

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Binary ethosome vesicles have been developed as flexible lipid vesicles for the enhanced physicochemical stability and skin delivery of drugs. This work aimed to prepare phloretin-loaded propylene glycol ethosomes (PHL-PGEs) to improve their stability, skin permeability and antioxidant activity. PHL-PGEs were prepared via the ethanol injection method and optimized using different weight ratios of ethanol to propylene glycol (PG). When the ethanol/PG mass ratio changed from 10:0 to 0:10, the encapsulation efficiency and stability of ethosomes increased. At a PHL concentration of 1mg/mL, the EE% was 89.42 ± 2.42 and the DL% was 4.21 ± 0.04, which exhibited their highest values. The encapsulation of the PHL in the PHL-PGEs was strengthened via XRD analysis and FTIR analysis. The results of the in vitro percutaneous permeability test demonstrated that the combined use of ethanol and PG exhibited a notable enhancement in skin permeability, and the skin retention of PHL-PGEs was 1.06 times that of PHL-ethosomes (PHL-Es) and 2.24 times that of the PHL solution. An in vitro antioxidant activity study indicated that solubility and antioxidant activity was potentiated via the nanoencapsulation of phloretin. Therefore, these results confirm the potential of this nanocarrier to enhance physicochemical stability, skin permeability and antioxidant activity.

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Section: Resultsmentioning

confidence: 99%

Section: Characterization Of Ethosomesmentioning

confidence: 92%

Designed Fabrication of Phloretin-Loaded Propylene Glycol Binary Ethosomes: Stability, Skin Permeability and Antioxidant Activity

Zhang,

Zhuang,

et al. 2023

Molecules

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“…By incorporating it into a protective delivery system, the chemical stability can be well protected, and the bioavailability can be enhanced facilitating its application in the fields of pharmacology and functional foods [2]. Several lipid-based formulations such as oil-in-water emulsions, micelles [3], niosomes [4], nanostructured lipid carriers [5], solid self-nanoemulsifying drug-delivery systems [6], liquid crystalline nanostructures, liposome-micelle-hybrids [7], liquid crystalline lipid nanoparticles [8] and liposomes [9] have been designed to entrap Cur and increase the absorption and efficacy in the targeted site. The bioavailability of Cur can be influenced by the form of carriers and interfacial properties [10,11].…”

Section: Introductionmentioning

confidence: 99%

“…It has been demonstrated that substituting part of a soybean phospholipid with a hydrogenated soybean phospholipid in curcumin-loaded liposomes can enhance the stability and release performances of curcumin [9]. The liposomes composed of lecithin and emulsifiers including Tween 80 and decaglycerol monolaurate formed a new liposome-micelle-hybrid which can increase the solubility of curcumin in water [7]. Moreover, the self-assembled lyotropic liquid crystalline nanostructures formed by monoolein-PEGylated lipid mixture can serve for the encapsulation of additional active substances to target various disease mechanisms [17].…”

Section: Introductionmentioning

confidence: 99%

Physicochemical and In Vitro Digestion Properties of Curcumin-Loaded Solid Lipid Nanoparticles with Different Solid Lipids and Emulsifiers

Chen

Lee

et al. 2023

Foods

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Curcumin-loaded solid lipid nanoparticles (Cur-SLN) were prepared using medium- and long chain diacylglycerol (MLCD) or glycerol tripalmitate (TP) as lipid matrix and three kinds of surfactants including Tween 20 (T20), quillaja saponin (SQ) and rhamnolipid (Rha). The MLCD-based SLNs had a smaller size and lower surface charge than TP-SLNs with a Cur encapsulation efficiency of 87.54–95.32% and the Rha-based SLNs exhibited a small size but low stability to pH decreases and ionic strength. Thermal analysis and X-ray diffraction results confirmed that the SLNs with different lipid cores showed varying structures, melting and crystallization profiles. The emulsifiers slightly impacted the crystal polymorphism of MLCD-SLNs but largely influenced that of TP-SLNs. Meanwhile, the polymorphism transition was less significant for MLCD-SLNs, which accounted for the better stabilization of particle size and higher encapsulation efficiency of MLCD-SLNs during storage. In vitro studies showed that emulsifier formulation greatly impacted on the Cur bioavailability, whereby T20-SLNs showed much higher digestibility and bioavailability than that of SQ- and Rha-SLNs possibly due to the difference in the interfacial composition. Mathematical modeling analysis of the membrane release further confirmed that Cur was mainly released from the intestinal phase and T20-SLNs showed a faster release rate compared with other formulations. This work contributes to a better understanding of the performance of MLCD in lipophilic compound-loaded SLNs and has important implications for the rational design of lipid nanocarriers and in instructing their application in functional food products.

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Recent Advancements of Lipid Nanoparticles in Nutraceutical Delivery Systems

Al Huq,

Mubarak,

Srinivasan

2024

Handbook of Nanofillers

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Hybrid liposomes composed of hydrophilic emulsifiers and lecithin: Physicochemical, interaction and curcumin loading properties

Cited by 10 publications

References 33 publications

Designed Fabrication of Phloretin-Loaded Propylene Glycol Binary Ethosomes: Stability, Skin Permeability and Antioxidant Activity

Designed Fabrication of Phloretin-Loaded Propylene Glycol Binary Ethosomes: Stability, Skin Permeability and Antioxidant Activity

Physicochemical and In Vitro Digestion Properties of Curcumin-Loaded Solid Lipid Nanoparticles with Different Solid Lipids and Emulsifiers

Recent Advancements of Lipid Nanoparticles in Nutraceutical Delivery Systems

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