Hybrid manufacturing of highly stretchable functionalized membrane for joint wound treatment

Yang, Liu; Lou, Yi; Zhang, Guoping; Sun, Yue; Yang, Yang; Wu, Jindan; Ye, Yanyuan; Chu, Xiaofan; Du, Lei; Jiang, Zhihua; Xu, Huaizhong

doi:10.1016/j.colsurfa.2023.132655

Cited by 5 publications

(2 citation statements)

References 39 publications

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“…Several groups have recently performed MEW onto SES membranes to form skin 37 , blood vessels 38 in vitro and wound dressings 39 . As an example, we imparted fluorescence into SES membranes using CPPs and performed MEW onto this substrate with [n]CPP-PCL blend.…”

Section: Ses Of [N]cpp-pclmentioning

confidence: 99%

[n]Cycloparaphenylenes as Compatible Fluorophores for Melt Electrowriting

Hall,

Reid,

Liashenko

et al. 2024

Preprint

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Fluorescent probes are an indispensable tool in the realm of bioimaging technologies, providing valuable insights into the assessment of biomaterial integrity and structural properties. However, incorporating fluorophores into scaffolds made from melt electrowriting (MEW) poses a challenge due to the sustained, elevated temperatures that this processing technique requires. In this context, we report that [n]cycloparaphenylenes ([n]CPPs) serve as excellent fluorophores for MEW processing with the additional benefit of customizable emissions profiles with the same excitation wavelength. We use three fluorescent blends with distinct [n]CPPs with emission wavelengths of either 466 nm, 494 nm, or 533 nm, identifying 0.01 wt.% as the preferred concentration. We discover that [n]CPPs disperse well within poly(ε-caprolactone) (PCL) and maintain their fluorescence even after a week of continuous heating at 80°C. The [n]CPP-PCL blends show no cytotoxicity and support counterstaining with commonly used DAPI (Ex/Em: 359nm/457nm), rhodamine- (Ex/Em: 542/565 nm), and fluorescein-tagged (Ex/Em: 490/515 nm) phalloidin stains. Using different color [n]CPP-PCL blends, we sequentially deposit different MEW fibers into a semi-woven scaffold and onto a solution electrospun membrane containing [8]CPP as a contrasting substrate for the [10]CPP MEW fibers. In general, [n]CPPs are potent fluorophores for MEW, providing new imaging options for this technology. Introduction

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Section: Ses Of [N]cpp-pclmentioning

confidence: 99%

[n]Cycloparaphenylenes as Compatible Fluorophores for Melt Electrowriting

Hall,

Reid,

Liashenko

et al. 2024

Preprint

View full text Add to dashboard Cite

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“…This feature can be achieved by combining bactericide compounds with ink precursors. After several trials on various materials, researchers have found that silver nanoparticles produce effective results with antibacterial properties added to polymerfabricated membranes [1,58]. Considering their antimicrobial attributes, these membranes have wide applicability, ranging from wound healing to supporting bones and tissues in restructuring surgeries.…”

Section: Polymer-based Membranes With Antibacterial Propertiesmentioning

confidence: 99%

Recent advancement and trends in the development of membranes having bactericidal attributes via direct ink writing

Lanke,

Patadiya,

Banerjee

et al. 2024

Biomed. Mater.

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The necessity for orthopedic prostheses, implants, and membranes to treat diseases, trauma, and other disasters has increased as the risk of survive through various factors has intensified exponentially. Considering exponential growth in demand, it has been observed that the traditional technology of grafts and membranes lags to fulfill the demand and effectiveness simultaneously. These challenges in traditional methodologies prompted a revolutionary shift in the biomedical industry when Additive manufacturing (AM) emerged as an alternative fabrication technique for medical equipments such as prostheses, implants, and membranes. However these techniques were fast and precise the major attributes of the biomedical materials were the processability, bactericidal nature, biocompatibility, biodegradability, and nontoxicity together with good mechanical properties. Major challenges faced by researchers in the present-day scenario regarding materials are the lack of bactericidal attributes in tailored material, though having better mechanical as well as biocompatible properties, which, on the other hand, are primary critical factors too, in the healthcare sector. Hence considering the advantages of additive manufacturing and need for membranes with bacteriacidal attributes this present review will highlight the studies based on the manufacturing of membranes with bacteria-resistant properties majorly using direct ink writing and some additive manufacturing techniques and the reasoning behind the antibacterial attributes of those composite materials.

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[n]Cycloparaphenylenes as Compatible Fluorophores for Melt Electrowriting

Hall,

Reid,

Liashenko

et al. 2024

Small

View full text Add to dashboard Cite

Fluorescent probes are an indispensable tool in the realm of bioimaging technologies, providing valuable insights into the assessment of biomaterial integrity and structural properties. However, incorporating fluorophores into scaffolds made from melt electrowriting (MEW) poses a challenge due to the sustained, elevated temperatures that this processing technique requires. In this context, [n]cycloparaphenylenes ([n]CPPs) serve as excellent fluorophores for MEW processing with the additional benefit of customizable emissions profiles with the same excitation wavelength. Three fluorescent blends are used with distinct [n]CPPs with emission wavelengths of either 466, 494, or 533 nm, identifying 0.01 wt% as the preferred concentration. It is discovered that [n]CPPs disperse well within poly(ε‐caprolactone) (PCL) and maintain their fluorescence even after a week of continuous heating at 80 °C. The [n]CPP‐PCL blends show no cytotoxicity and support counterstaining with commonly used DAPI (Ex/Em: 359 nm/457 nm), rhodamine‐ (Ex/Em: 542/565 nm), and fluorescein‐tagged (Ex/Em: 490/515 nm) phalloidin stains. Using different color [n]CPP‐PCL blends, different MEW fibers are sequentially deposited into a semi‐woven scaffold and onto a solution electrospun membrane composed of [8]CPP‐PCL as a contrasting substrate for the [10]CPP‐PCL MEW fibers. In general, [n]CPPs are potent fluorophores for MEW, providing new imaging options for this technology.

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Hybrid manufacturing of highly stretchable functionalized membrane for joint wound treatment

Cited by 5 publications

References 39 publications

[n]Cycloparaphenylenes as Compatible Fluorophores for Melt Electrowriting

[n]Cycloparaphenylenes as Compatible Fluorophores for Melt Electrowriting

Recent advancement and trends in the development of membranes having bactericidal attributes via direct ink writing

[n]Cycloparaphenylenes as Compatible Fluorophores for Melt Electrowriting

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