Over the last few decades, globalization has weakened the US manufacturing sector. The COVID-19 pandemic revealed import dependencies and supply chain shocks that have raised public and private awareness of the need to rebuild domestic production. A range of new technologies, collectively called Industry 4.0, create opportunities to revolutionize domestic and local manufacturing. Success depends on further refinement of those technologies, broad implementation throughout private companies, and concerted efforts to rebuild the industrial commons, the national ecosystem of producers, suppliers, service providers, educators, and workforce necessary to regain a competitive, innovative manufacturing sector. A recent workshop sponsored by the Engineering Research Visioning Alliance (ERVA) identified a range of challenges and opportunities to build a resilient, flexible, scalable, and high-quality manufacturing sector. This paper provides a strategic roadmap for regaining US manufacturing leadership by briefly summarizing discussions at the ERVA-sponsored workshop held in 2023 and providing additional analysis of key technical and economic issues that must be addressed to achieve dynamic, high-value manufacturing in the USA. The focus of this presentation is on discrete manufacturing of production of structural components, a large subset of total manufacturing that produces high-value inputs and finished products for domestic consumption and export.