Hybrid model of radio channels occupancy prediction for dynamic spectrum access

Łopatka, Jerzy; Malon, Krzysztof; Kryk, Michał

doi:10.23919/ursi.2018.8406694

Cited by 5 publications

(1 citation statement)

References 4 publications

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“…Recently, promising results have been obtained with immunotherapy (monoclonal antibodies, e.g., ipilimumab), target therapy (BRAF inhibitors, e.g., vemurafenib; MEK inhibitors, e.g., cobimetinib), and combined treatments (BRAF inhibitors associated to MEK inhibitors, e.g., vemurafenib + cobimetinib) (Napolitano et al 2018;Schadendorf et al 2018). However, these treatments induce severe toxicity, including neutropenia, thrombocytopenia, fatigue, nausea, vomiting, and neurosensory troubles (Jang and Atkins 2014;Roos et al 2014;Lopatka et al 2018;Voskoboynik and Arkenau 2014). The wide range of antineoplastic treatments Electronic supplementary material The online version of this article (https://doi.org/10.1007/s43450-020-00036-2) contains supplementary material, which is available to authorized users.…”

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confidence: 99%

Carotenoids from Rhodomonas salina Induce Apoptosis and Sensitize A2058 Melanoma Cells to Chemotherapy

Oliveira-Júnior

Nicolau

Bonnet

et al. 2020

Rev. Bras. Farmacogn.

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Melanoma is an aggressive tumor with invasive and metastatic potential, frequently exhibiting multidrug resistance mechanisms. In our continuous search for antimelanoma molecules, we have identified some effective marine compounds capable of not only inducing cell death, but also of sensitizing chemoresistant tumor cells to clinically used anticancer drugs. In this report, the cryptophyte Rhodomonas salina (Wislouch) D.R.A.Hill & R.Wetherbee, Pyrenomonadaceae, was chemically investigated in order to identify pigments efficiently inhibiting melanoma cells proliferation. All pharmacological tests were performed on A2058 cells expressing the oncogenic BRAF V600E mutation and resistant to dacarbazine treatment. Flash chromatography of R. salina ethanol extract led to purification of alloxanthin and crocoxanthin, which showed significant antiproliferative activity against A2058 cells, exhibiting IC 50 = 29 and 50 μM, respectively. These carotenoids promoted growth inhibition, decreased cell migration, and induced apoptosis and sub-G1 cells accumulation after 72 h of treatment. In addition, alloxanthin potentiated the cytotoxic activity of vemurafenib (a BRAF inhibitor) and restored the sensitivity of A2058 cells to dacarbazine treatment.

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