Hybrid morphologies of paramagnetic manganese-based nanoparticles as theranostics

Design of manganese-based nanomaterials for pharmaceutical and biomedical applications

“…These include drug delivery, gene delivery, hyperthermia therapy, photothermal therapy, and magnetic resonance imaging (MRI) and so on. 1,161 As Mn-based NSs have shown their potential effect in the delivery of therapeutic agents and as detection, they are often considered as theranostic NSs.…”

“…In the past two decades, various metals or metal-based nanomaterials have been investigated extensively due to their unique properties in various fields, such as the steel industry, water treatment, catalysis, magnetic storage devices, electronics, batteries, diagnostics, and drug delivery. 1 In this review, we have highlighted the synthesis strategies, properties, and applications of manganese-based structures (Mn-NSs) in the biomedical field, such as drug delivery, gene delivery, magnetic resonance imaging, hyperthermia, photothermal and biosensing. Mn-based nanostructures (Mn-NSs) have been explored as carriers for the delivery of drugs and genetic materials and contrast agents in magnetic resonance imaging.…”

Merging of Bi-Modality of Ultrafast Laser Processing: Heating of Si/Au Nanocomposite Solutions with Controlled Chemical Content

“…At the same time, similar laser sources are widely used for the fabrication of various nanomaterials in gaseous and liquid environments. Here, pulsed laser ablation in liquids (PLALs) is one of the simplest as well as versatile techniques to directly synthesize colloidal solutions of “green” nanostructures that can be employed for different applications such as biosensing, bioimaging, catalysis or theranostics [ 6 , 7 , 8 , 9 , 10 ]. Indeed, the easy preparation of colloids containing semiconductor, metallic or bimetallic NPs is successfully demonstrated using a large set of different laser sources [ 11 , 12 , 13 , 14 , 15 , 16 , 17 ].…”

Biocompatible Hollow Gadolinium Oxide Nanocarriers for the Transport of Bioactive Molecules to Cells

“…8,47,48 Among several nanomaterials, gadolinium oxide nanoparticles (Gd 2 O 3 -NPs) have gained significant attention for their perspective applications in magnetic resonance imaging, luminescence devices, as well as microelectronics due to their high density of Gd 3+ ions per particle and surface-to-volume ratio, resulting in increased water coordination sites and rotational correlation time compared to typical Gd 3+ complexes. 9,10,49 Additionally, the small-sized Gd 2 O 3 -NPs decrease the tumbling rate of molecules, leading to increased relaxivity values. 11,12 Moreover, gadolinium-based nanomaterials are efficient probes for imaging experiments due to their high surface-to-volume ratio and enhanced magnetic properties of ultrafine particles; [13][14][15][16]26 however, their biological applications face certain challenges due to insufficient biocompatibility caused by the leaching of toxic gadolinium ions.…”

“…Among several nanomaterials, gadolinium oxide nanoparticles (Gd 2 O 3 -NPs) have gained significant attention for their perspective applications in magnetic resonance imaging, luminescence devices, as well as microelectronics due to their high density of Gd 3+ ions per particle and surface-to-volume ratio, resulting in increased water coordination sites and rotational correlation time compared to typical Gd 3+ complexes. ,, Additionally, the small-sized Gd 2 O 3 -NPs decrease the tumbling rate of molecules, leading to increased relaxivity values. , Moreover, gadolinium-based nanomaterials are efficient probes for imaging experiments due to their high surface-to-volume ratio and enhanced magnetic properties of ultrafine particles; − , however, their biological applications face certain challenges due to insufficient biocompatibility caused by the leaching of toxic gadolinium ions . In recent years, there has been progress in enhancing the biocompatibility and long-term safety of Gd 2 O 3 -based materials by coating them with adequate overlayers including silica, catechol ligands, hydrophilic polymers, and doped shell materials. − These approaches not only safeguard fluorescence imaging but also open doors for the use of gadolinium-based materials for therapy in view of their longer blood circulation time and precise labeling in different rat models including breast and osteosarcoma cells (MCF-7 and MG63). − ,− …”