Hybrid multi-wavelength nonlinear photoacoustic sensing and imaging

Duan, Tingyang; Lan, Hengrong; Zhong, Hongtao; Zhou, Meng; Zhang, Ruochong; Gao, Fei

doi:10.1364/ol.43.005611

Cited by 29 publications

(16 citation statements)

References 24 publications

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“…It can be required for finding the average intensity levels μ 0 and μ 1 which are utilized in equation (5). If these values are c, the Otsu based on class σ 2 B is determined in equation (6).…”

Section: Design Of Multilevel Ostumentioning

confidence: 99%

“…In such cases, the iterative methods are well-adopted when using an appropriate regularization. PAT is a noninvasive combined physics biomedical imaging approach that conveniently integrates the higher contrast of pure optical imaging through the higher spatial resolution of ultrasound imaging [ 6 ]. It can be dependent upon the generation of acoustic waves through illuminating a semitransparent biological or clinical object with a shorter optical pulse.…”

Section: Introductionmentioning

confidence: 99%

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Design of Metaheuristic Optimization‐Based Vascular Segmentation Techniques for Photoacoustic Images

Vaiyapuri

Dutta²,

Sikkandar

et al. 2022

Contrast Media & Molecular Imaging

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Biomedical imaging technologies are designed to offer functional, anatomical, and molecular details related to the internal organs. Photoacoustic imaging (PAI) is becoming familiar among researchers and industrialists. The PAI is found useful in several applications of brain and cancer imaging such as prostate cancer, breast cancer, and ovarian cancer. At the same time, the vessel images hold important medical details which offer strategies for a qualified diagnosis. Recently developed image processing techniques can be employed to segment vessels. Since vessel segmentation on PAI is a difficult process, this paper employs metaheuristic optimization-based vascular segmentation techniques for PAI. The proposed model involves two distinct kinds of vessel segmentation approaches such as Shannon’s entropy function (SEF) and multilevel Otsu thresholding (MLOT). Moreover, the threshold value and entropy function in the segmentation process are optimized using three metaheuristics such as the cuckoo search (CS), equilibrium optimizer (EO), and harmony search (HS) algorithms. A detailed experimental analysis is made on benchmark PAI dataset, and the results are inspected under varying aspects. The obtained results pointed out the supremacy of the presented model with a higher accuracy of 98.71%.

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Section: Design Of Multilevel Ostumentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Design of Metaheuristic Optimization‐Based Vascular Segmentation Techniques for Photoacoustic Images

Vaiyapuri

Dutta²,

Sikkandar

et al. 2022

Contrast Media & Molecular Imaging

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“…While the above works are effective, several aspects may limit the wide applications of nonlinear PAM. First, additional laser sources are required, imposing high cost on the imaging system [4][5][6]10]. Secondly, sophisticated control of the time intervals between laser pulses (e.g., a time interval shorter than the thermal relaxation time of a medium of interest) makes the experimental implementation complicated [4][5][6][7][8][9][10]14].…”

Section: Introductionmentioning

confidence: 99%

“…Another work introduced a thermal contrast parameter to emphasize the contrast enhancement due to heating, and ex vivo imaging of porcine tissue was demonstrated [9]. Besides, by employing a combination of a set of continuous‐wave lasers with different wavelengths (for heating) and a pulsed laser (for photoacoustic excitation), selective contrast enhancement of different absorbers was achieved [10]. Another recent work proposed using a continuous‐wave laser for heating an absorber [11].…”

Section: Introductionmentioning

confidence: 99%

“…First, additional laser sources are required, imposing high cost on the imaging system [4][5][6]10]. Secondly, sophisticated control of the time intervals between laser pulses (e.g., a time interval shorter than the thermal relaxation time of a medium of interest) makes the experimental implementation complicated [4][5][6][7][8][9][10]14]. The mechanism is termed transient heating, in contrast to steady heating [15][16][17].…”

Section: Introductionmentioning

confidence: 99%

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Investigation of nonlinear photoacoustic microscopy using a low‐cost infrared lamp

Seong

Yang

Han

et al. 2022

Journal of Biophotonics

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Nonlinear photoacoustic microscopy (PAM) is a novel approach to enhance contrast and resolution. In this study, a low‐cost infrared (IR) lamp as a simple approach for nonlinear PAM is demonstrated. Numerical simulations are first performed to verify the nonlinear photoacoustic effect under steady heating for two cases: (a) Differentiation of absorbers with different Grüneisen coefficients; (b) enhancement of photoacoustic amplitude. Then, sets of experiments are conducted to experimentally demonstrate our proposed approach: (a) Longitudinal monitoring of photoacoustic A‐line signals from two samples, porcine tissue ex vivo and hemoglobin and indocyanine green (ICG) solutions in tubes in vitro for demonstrating the above‐mentioned two cases; (b) PAM imaging of hemoglobin and ICG solutions in tubes before and after IR lamp heating. Different signal change and amplitude enhancement are observed in different demonstrations, showing the efficacy of the proposed approach. By virtue of cost‐effectiveness and decent performance, our work facilitates nonlinear PAM studies.

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Saliency enhancement method for photoacoustic molecular imaging based on Grüneisen relaxation nonlinear effect

Wang,

Xie,

Lin

et al. 2024

Journal of Biophotonics

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Photoacoustic molecular imaging technology has a wide range of applications in biomedical research. In practical scenarios, both the probes and blood generate signals, resulting in the saliency of the probes in the blood environment being diminished, impacting imaging quality. Although several methods have been proposed for saliency enhancement, they inevitably suffer from moderate generality and detection speed. The Grüneisen relaxation (GR) nonlinear effect offers an alternative for enhancing saliency and can improve generality and speed. In this article, the excitation and detection efficiencies are optimized to enhance the GR signal amplitude. Experimental studies show that the saliency of the probe is enhanced. Moreover, the issue of signal aliasing is studied to ensure the accuracy of enhancement results in the tissues. In a word, the feasibility of the GR‐based imaging method in saliency enhancement is successfully demonstrated in the study, showing the superiorities of good generality and detection speed.

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Hybrid multi-wavelength nonlinear photoacoustic sensing and imaging

Cited by 29 publications

References 24 publications

Design of Metaheuristic Optimization‐Based Vascular Segmentation Techniques for Photoacoustic Images

Design of Metaheuristic Optimization‐Based Vascular Segmentation Techniques for Photoacoustic Images

Investigation of nonlinear photoacoustic microscopy using a low‐cost infrared lamp

Saliency enhancement method for photoacoustic molecular imaging based on Grüneisen relaxation nonlinear effect

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