2005
DOI: 10.1021/ja043600x
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Hybrid Nanocapsules:  Interactions of ABA Block Copolymers with Liposomes

Abstract: Amphiphilic ABA triblock copolymers, such as poly(2-methyloxazoline)-block-poly(dimethylsiloxan)-block-poly(2-methyloxazoline) (PMOXA-PDMS-PMOXA), form vesicular structures. Here, the interaction of these ABA molecules with lipids is investigated by electron microscopy, fluorescence spectroscopy, light scattering, and differential scanning calorimetry. Our observations suggest the formation of homogeneous mixed polymer-lipid composites, independent of preparation method, i.e. film hydration, dispersion, or det… Show more

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Cited by 125 publications
(117 citation statements)
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“…Studies reported to date on hybrid vesicles have not yielded detailed information on the efficiency of hybrid vesicle formation in bulk solution [14][15][16][17][18][19][20][21]. Flow cytometry has been demonstrated as a useful tool to study vesicle populations [23].…”
Section: Resultsmentioning
confidence: 99%
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“…Studies reported to date on hybrid vesicles have not yielded detailed information on the efficiency of hybrid vesicle formation in bulk solution [14][15][16][17][18][19][20][21]. Flow cytometry has been demonstrated as a useful tool to study vesicle populations [23].…”
Section: Resultsmentioning
confidence: 99%
“…It may be concluded that liposomes and polymersomes have their own particular benefits and limitations, which is why the preparation of hybrid membranes consisting of phospholipids and block copolymers is attracting increasing attention [14][15][16][17][18][19][20][21]. In this way, the robustness and chemical versatility of polymersomes can be combined with the softness and biocompatibility of liposomes.…”
Section: Introductionmentioning
confidence: 99%
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“…Diblock copolymers have also been widely used for the development of synthetic vesicles denoted polymersomes, which exhibit excellent stability and mechanical properties (5,6). However, they are polydisperse and sometimes toxic and exhibit bilayers from 8 to 50 nm, which are thicker than those of biological membranes (about 4 nm), making them less suitable for incorporating proteins and other components of biological origin in their bilayers (7)(8)(9)(10). A third class of synthetic vesicles denoted dendrimersomes (DSs) has been elaborated by the self-assembly of amphiphilic JDs (11).…”
mentioning
confidence: 99%
“…drug and gene delivery vectors (1,9,10,16). A three-component lipid system consisting of 30% 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC), 50% brain sphingomyelin, and 20% cholesterol was reported to form giant unilamellar, peanut-shaped biphasic liposomes (17,18).…”
mentioning
confidence: 99%