Hybrid nanocomposite multinetwork hydrogel containing magnesium hydroxide nanoparticles with enhanced antibacterial activity for wound dressing applications

Qu, Jiahao; Li, Jing; Zhu, Weiping; Xu, Yufang; Zhou, Shengmin; Yang, Yangyang; Qian, Xuhong

doi:10.1016/j.polymer.2022.124902

Cited by 20 publications

(11 citation statements)

References 24 publications

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“…Following Gram-positive and Gram-negative bacterial strains, 1 E. coli, 2 P multocida, 3 S. aureus, 4 and B. subtilis were used to study the antimicrobial activities of chitosan/AV-based polymeric membranes.…”

Section: Methodsmentioning

confidence: 99%

“…Commonly used synthetic polymeric bandages have poor healing efficacy for chronic wounds. 1 - 3 The significant limitations of skin injury treatment formulations such as gels and ointments include their inability to sustain the release of medicine for an extended period of time at wet injury sites due to their short-lived existence. 4 , 5 Furthermore, these dressings do not provide adequate moisture, pH, or gas exchange to injured skin.…”

Section: Introductionmentioning

confidence: 99%

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Polymeric Membranes of Chitosan/Aloe Vera Gel Fabrication With Enhanced Swelling and Antimicrobial Properties for Biomedical Applications

et al. 2023

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Since ancient times, medicinal plants have been used as traditional medicine to treat a variety of ailments. Aloe vera (AV) gel’s therapeutic potential is one of the most effective approach in the fabrication of functional materials. The current study aimed to prepare the AV and chitosan (CS) membranes using various cross-linkers that were characterized using X-ray diffraction (XRD), scanning electron microscopy (SEM), Fourier transform-infrared (FT-IR) spectroscopy, thermal gravimetric analysis (TGA), and ultraviolet-visible (UV-Visible) techniques, as well as swelling ratio and antimicrobial studies. SEM analysis revealed that the membrane is porous, with interconnected pores. The inclusion of AV contents in the membrane improved thermal stability and crystallinity. The swelling ratio of the ACPG-3 membrane with a 2:1 CS to AV ratio was 366%. The membranes showed promising antimicrobial activity against Escherichia coli, Staphylococcus aureus, Bacillus subtilis, and Pasteurella multocida strains. The findings revealed that polymeric CS/AV membranes have effective potential for use in the biomedical field.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Polymeric Membranes of Chitosan/Aloe Vera Gel Fabrication With Enhanced Swelling and Antimicrobial Properties for Biomedical Applications

et al. 2023

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“…[53] Yang et al synthesized a magnesium ion-doped heterogeneous nanocomposite hydrogel that promotes wound healing (Figure 4e). [54] In conclusion, antibacterial hydrogels containing different metal ions can be administered on demand to kill bacteria and promote wound healing by blocking the absorption of bacterial must ions. Hydrogels loaded with different metal ions are of great advantage in disease treatment, and in future biomedical development, a wide variety of like-minded smart hydrogels can be designed for anti-tumor, smart drug delivery, smart sterilization, smart anti-infection, and smart anti-fouling.…”

Section: Biomedical Potential Of Other Metal-loaded Antibacterial Hyd...mentioning

confidence: 99%

mentioning

confidence: 99%

Antimicrobial Hydrogels: Potential Materials for Medical Application

Li,

Han,

et al. 2023

Small

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Microbial infections based on drug‐resistant pathogenic organisms following surgery or trauma and uncontrolled bleeding are the main causes of increased mortality from trauma worldwide. The prevalence of drug‐resistant pathogens has led to a significant increase in medical costs and poses a great threat to the normal life of people. This is an important issue in the field of biomedicine, and the emergence of new antimicrobial materials hydrogels holds great promise for solving this problem. Hydrogel is an important material with good biocompatibility, water absorption, oxygen permeability, adhesion, degradation, self‐healing, corrosion resistance, and controlled release of drugs as well as structural diversity. Bacteria‐disturbing hydrogels have important applications in the direction of surgical treatment, wound dressing, medical device coating, and tissue engineering. This paper reviews the classification of antimicrobial hydrogels, the current status of research, and the potential of antimicrobial hydrogels for one application in biomedicine, and analyzes the current research of hydrogels in biomedical applications from five aspects: metal‐loaded hydrogels, drug‐loaded hydrogels, carbon‐material‐loaded hydrogels, hydrogels with fixed antimicrobial activity and biological antimicrobial hydrogels, and provides an outlook on the high antimicrobial activity, biodegradability, biocompatibility, injectability, clinical applicability and future development prospects of hydrogels in this field.

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“…Antibacterial nanomaterials have been designed to inhibit the growth of bacteria and control the spread of infectious disease [1][2][3][4], and have been used in a wide range of fields such as textile, ceramic and plastic [5,6]. As nanotechnology rapidly expands, antibacterial nanoparticles (NPs) are entering the environment, and it is inevitable that human will be exposed to the NPs [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Investigation of the Biosafety of Antibacterial Mg(OH)2 Nanoparticles to a Normal Biological System

Wang

Liu

et al. 2023

JFB

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The toxicity of Mg(OH)2 nanoparticles (NPs) as antibacterial agents to a normal biological system is unclear, so it is necessary to evaluate their potential toxic effect for safe use. In this work, the administration of these antibacterial agents did not induce pulmonary interstitial fibrosis as no significant effect on the proliferation of HELF cells was observed in vitro. Additionally, Mg(OH)2 NPs caused no inhibition of the proliferation of PC-12 cells, indicating that the brain’s nervous system was not affected by Mg(OH)2 NPs. The acute oral toxicity test showed that the Mg(OH)2 NPs at 10,000 mg/kg induced no mortality during the administration period, and there was little toxicity in vital organs according to a histological analysis. In addition, the in vivo acute eye irritation test results showed little acute irritation of the eye caused by Mg(OH)2 NPs. Thus, Mg(OH)2 NPs exhibited great biosafety to a normal biological system, which was critical for human health and environmental protection.

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Hybrid nanocomposite multinetwork hydrogel containing magnesium hydroxide nanoparticles with enhanced antibacterial activity for wound dressing applications

Cited by 20 publications

References 24 publications

Polymeric Membranes of Chitosan/Aloe Vera Gel Fabrication With Enhanced Swelling and Antimicrobial Properties for Biomedical Applications

Polymeric Membranes of Chitosan/Aloe Vera Gel Fabrication With Enhanced Swelling and Antimicrobial Properties for Biomedical Applications

Antimicrobial Hydrogels: Potential Materials for Medical Application

Investigation of the Biosafety of Antibacterial Mg(OH)2 Nanoparticles to a Normal Biological System

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