Hybrid nanoparticles to cross the blood–brain barrier

Desai, Harita R.; Shinde, Ujwala A.

doi:10.1016/b978-0-323-90773-6.00002-6

Cited by 3 publications

(2 citation statements)

References 74 publications

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“…Hybrid micelles composed of cholic acids and mesoporous silica increased the accumulation of drugs in tumor tissue and improved the anti‐tumor efficacy in a murine model of brain cancer. [ 327 ] Recent studies have shown that hybrid nanogels can be used to enhance the efficacy of immunotherapeutic treatments by encapsulating drugs or cells and targeting them toward specific sites in the body. [ 328 ] One of the key advantages of hybrid nanogels is their ability to protect immunotherapeutic agents from degradation in the body and release them in a controlled manner over time.…”

Section: Inorganic Nanomaterial‐based Tumor Immunotherapymentioning

confidence: 99%

Four Ounces Can Move a Thousand Pounds: The Enormous Value of Nanomaterials in Tumor Immunotherapy

Chen

Yue

Yang

et al. 2023

Adv Healthcare Materials

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The application of nanomaterials in healthcare has emerged as a promising strategy due to their unique structural diversity, surface properties, and compositional diversity. In particular, they have found a significant role in improving drug delivery and inhibiting the growth and metastasis of tumor cells. Moreover, recent studies have highlighted their potential in modulating the tumor microenvironment (TME) and enhancing the activity of immune cells to improve tumor therapy efficacy. Various types of nanomaterials are currently utilized as drug carriers, immunosuppressants, immune activators, immunoassay reagents, and more for tumor immunotherapy. Necessarily, nanomaterials used for tumor immunotherapy can be grouped into two categories: organic and inorganic nanomaterials. Though both have shown the ability to achieve the purpose of tumor immunotherapy, their composition and structural properties result in differences in their mechanisms and modes of action. Organic nanomaterials can be further divided into organic polymers, cell membranes, nanoemulsion‐modified, and hydrogel forms. At the same time, inorganic nanomaterials can be broadly classified as nonmetallic and metallic nanomaterials. The current review aims to explore the mechanisms of action of these different types of nanomaterials and their prospects for promoting tumor immunotherapy.This article is protected by copyright. All rights reserved

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Section: Inorganic Nanomaterial‐based Tumor Immunotherapymentioning

confidence: 99%

Four Ounces Can Move a Thousand Pounds: The Enormous Value of Nanomaterials in Tumor Immunotherapy

Chen

Yue

Yang

et al. 2023

Adv Healthcare Materials

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“…These are single-layered amphiphilic NCs that enable for regulated drug release. These NCs boost the BBB's ability to absorb hydrophobic medicines for the purpose of treating the brain disorders [36]. Micelles have also demonstrated encouraging outcomes to carry different potent compounds, including peptides and small molecules [37].…”

Section: Micellesmentioning

confidence: 99%

Recent Advancements in Phyto Component Based Nanocarriers for Improved Treatment of Brain Disorders

Satapathy¹,

Pattnaik²,

Biswal³

et al. 2023

Drug Repurposing - Advances, Scopes and Opportunities in Drug Discovery

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Effective treatment of brain disorders remains a tough task in medical science. Age-old brain disorders like Parkinson’s (PD) and Alzheimer’s (AD) are yet to be managed effectively in spite of fabulous scientific progress over the last decades. Presently available treatment strategies have been found insufficient to tackle the out bursting cases of AD and PD. Indeed, presence of blood-brain barrier (BBB) highly hijacks success of conventional drug therapy. In this regard, phyto bioactive components delivered through nanocarrier (NCs) systems hold ray of hope in improving treatment benefits in brain disorders. Several NCs including polymeric nanoparticles, nanoliposomes, micelles, dendrimers have now being heavily researched to effectively deliver the phyto active components to brain tissue. NCs owing to their structural and physiological uniqueness have now been evolved with great potential for the treatment of brain disorders. Functionalization of brain specific ligands on the surface of NCs further makes them target specific, which might significantly improve bioavailability or reduce the off-target adverse effects. This chapter primarily focuses on recent advancements in phyto component loaded NCs employed for the treatment of brain disorders. The chapter especially covers existing impediments of phyto component based NCs for Parkinson and Alzheimer’s disease.

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Biomedical Applications of Hybrid Nanomaterials

Yingngam,

Sethabouppha,

Yingngam

et al. 2024

Technological Applications of Nano-Hybrid Composites

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The ever-evolving field of nanotechnology has led to groundbreaking advancements in biomedical science, particularly through the development of hybrid nanomaterials. This chapter explores the synthesis, characterization, and diverse biomedical applications of these materials, which combine the advantageous properties of both organic and inorganic constituents for optimized functionality. The text delves into the use of hybrid nanomaterials in areas such as drug delivery, diagnostics, tissue engineering, and biosensors. A key case study demonstrating the wound-healing applications of silver nanoparticle-loaded nanofibrous scaffolds is included. The chapter also addresses the challenges and ethical considerations associated with the clinical translation of these nanomaterials. Therefore, this chapter serves as a comprehensive guide for readers interested in understanding and harnessing the immense potential of hybrid nanomaterials in biomedical applications.

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Hybrid nanoparticles to cross the blood–brain barrier

Cited by 3 publications

References 74 publications

Four Ounces Can Move a Thousand Pounds: The Enormous Value of Nanomaterials in Tumor Immunotherapy

Four Ounces Can Move a Thousand Pounds: The Enormous Value of Nanomaterials in Tumor Immunotherapy

Recent Advancements in Phyto Component Based Nanocarriers for Improved Treatment of Brain Disorders

Biomedical Applications of Hybrid Nanomaterials

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