Hybrid nanoparticles with CO<sub>2</sub>-responsive shells and fluorescence-labelled magnetic cores

Guo, Jun; Wang, Niejun; Wu, Jingjun; Ye, Qiquan; Zhang, Chong; Xing, Xin‐Hui; Yuan, Jinying

doi:10.1039/c3tb21264e

Cited by 52 publications

(60 citation statements)

References 56 publications

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“…The macroinitiator (O-Br) then was employed in the ATRP of styrene in bulk using copper bromide (CuBr) catalyst and PMDETA ligand (Fig. 115 In the first step magnetic nanoparticles were prepared and 2-bromopropionyl bromide was used to attach the bromide onto the surface of the nanoparticles. The reaction continued for 16 h at 110 1C to obtain OS macroinitiator for the third step.…”

Section: Reversible Deactivation Radical Polymerization (Rdrp)mentioning

confidence: 99%

CO₂-responsive polymeric materials: synthesis, self-assembly, and functional applications

2016

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CO2 is an ideal trigger for switchable or stimuli-responsive materials because it is benign, inexpensive, green, abundant, and does not accumulate in the system. Many different CO2-responsive materials including polymers, latexes, solvents, solutes, gels, surfactants, and catalysts have been prepared. This review focuses on the preparation, self-assembly, and functional applications of CO2-responsive polymers. Detailed discussion is provided on the synthesis of CO2-responsive polymers, in particular using reversible deactivation radical polymerization (RDRP), formerly known as controlled/living radical polymerization (CLRP), a powerful technique for the preparation of well-defined (co)polymers with precise control over molecular weight distribution, chain-end functional groups, and polymer architectural design. Self-assembly in aqueous dispersed media is highlighted as well as emerging potential applications.

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Section: Reversible Deactivation Radical Polymerization (Rdrp)mentioning

confidence: 99%

CO₂-responsive polymeric materials: synthesis, self-assembly, and functional applications

2016

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“…57 1.20 g of Fe(acac)3 was dissolved in a mixture of 17 mL of 1-octadecene and 17 mL of oleylamine. The solution was dehydrated at 110 o C for 1 h. Then, the solution was quickly heated to 300 o C and kept at this temperature for 1 h under an argon atmosphere.…”

Section: Preparation Of Fe3o4 Nanoparticlesmentioning

confidence: 99%

CO₂-switchable drug release from magneto-polymeric nanohybrids

et al. 2015

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A CO 2 -responsive well-defined magneto-polymeric drug delivery system has been developed.An dosing release of doxorubicin (DOX) in vitro in a time-controllable manner can be easily executed under alternative CO 2 /N 2 treatment by these smart nanocarriers.CO2-resonsive well-defined core-shell-corona structure magnetic Fe3O4@SiO2-poly(N,Ndimethylaminoethyl methacrylate) (PDMAEMA) nanocarriers have been developed as efficient drug delivery system. The hybrid magnetic nanoparticles (MNPs) demonstrated a sandwich structure and high super-paramagnetic, biocompatibility properties as well as gas-responsive behavior. We found that the hydrodynamic radius (Rh) of the magnetic hybrid nanoparticles could be adjusted by alternate CO2/N2 treatment driving a switchable volume transition from contraction to expansion because of the CO2 responsiveness of PDMAEMA. The CO2-triggered protonation of the polymer shell gives rise to obvious zeta potential change of the nanoparticles. Importantly, the CO2 induced reversible "on-off" transformation makes it possible to perform an dosing release of doxorubicin (DOX) in vitro in a time-controllable manner which is of great significance in controlled drug release. In the presence of CO2, the drug release rate is significantly accelerated; while low drug release could be achieved by removal of CO2 using N2. Moreover, in vitro cytotoxicity represented that the CO2-responsive magnetic nanocarries have good biocompatibility and could be safely used in living systems.

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“…On the other hand, during the past decades, stimuli-responsive polymers which can adapt to changes in the local environment such as temperature, pH, ionic strength, light and magnetic field have attracted much attentions [25][26][27][28][29][30][31][32][33][34][35]. The ''smart'' materials have potential applications including catalysis, biosensors, controlled drug delivery, smart surfaces and tissue engineering.…”

Section: Introductionmentioning

confidence: 99%

When dual and multi-responsiveness meet molecular brushes

Guo

Peng

Yuan

2015

European Polymer Journal

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Hybrid nanoparticles with CO₂-responsive shells and fluorescence-labelled magnetic cores

Cited by 52 publications

References 56 publications

CO₂-responsive polymeric materials: synthesis, self-assembly, and functional applications

CO₂-responsive polymeric materials: synthesis, self-assembly, and functional applications

CO₂-switchable drug release from magneto-polymeric nanohybrids

When dual and multi-responsiveness meet molecular brushes

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Hybrid nanoparticles with CO2-responsive shells and fluorescence-labelled magnetic cores

Cited by 52 publications

References 56 publications

CO2-responsive polymeric materials: synthesis, self-assembly, and functional applications

CO2-responsive polymeric materials: synthesis, self-assembly, and functional applications

CO2-switchable drug release from magneto-polymeric nanohybrids

When dual and multi-responsiveness meet molecular brushes

Contact Info

Product

Resources

About

Hybrid nanoparticles with CO₂-responsive shells and fluorescence-labelled magnetic cores

CO₂-responsive polymeric materials: synthesis, self-assembly, and functional applications

CO₂-responsive polymeric materials: synthesis, self-assembly, and functional applications

CO₂-switchable drug release from magneto-polymeric nanohybrids