Hybrid Nanosystems Based on Nicotinate-Functionalized Mesoporous Silica and Silver Chloride Nanoparticles Loaded with Phenytoin for Preventing Pseudomonas aeruginosa Biofilm Development

Ugalde-Arbizu, Maider; Aguilera-Correa, John Jairo; Mediero, Aránzazu; Esteban, Jaime; Páez, Paulina Laura; Sebastián, Eider San; Gómez‐Ruiz, Santiago

doi:10.3390/ph15070884

Cited by 8 publications

(6 citation statements)

References 51 publications

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“…As can be seen in Table 5 , after PTN encapsulation in the material, the MIC and MBC values decreased considerably due to the additive effect between PTN and silver when at least 2 dilutions of the material used is considered. These results were even better than those previously reported by our group for a similar system [ 38 ]. Importantly, the release of PTN in physiological medium was studied on the 1-Ag@PTN material (see Figure S10 ).…”

Section: Resultscontrasting

confidence: 69%

“…Therefore, silver materials were shown to inhibit the growth of S. aureus and P. aeruginosa , which are predominant in chronic wounds and burns [ 50 , 51 ]. The effect of phenytoin sodium encapsulation in the 1-Ag material (yielding 1-Ag@PTN ) on wound tissue regeneration was also analyzed, since previous studies showed that silver and phenytoin sodium activities against P. aeruginosa [ 38 ] are additive. The MIC and MBC values of 1-Ag@PTN against the three strains of P. aeruginosa were estimated and are listed in Table 5 .…”

Section: Resultsmentioning

confidence: 99%

“…Furthermore, our study also involved the adsorption of phenytoin sodium, a well-known proliferative agent [ 35 , 36 , 37 ], onto one of the silver-functionalized materials, aiming at promoting healing of infected wounds. This proliferative agent demonstrated an additive antibacterial effect when co-administered with silver-containing species, while the phenytoin-loaded silver materials caused an almost complete eradication of P. aeruginosa infections in wound-like medium (including components that the synthesized materials would encounter in an in vivo model) and biofilms [ 38 ].…”

Section: Introductionmentioning

confidence: 99%

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Antibacterial Properties of Mesoporous Silica Nanoparticles Modified with Fluoroquinolones and Copper or Silver Species

Ugalde-Arbizu,

Aguilera-Correa,

San Sebastian

et al. 2023

Pharmaceuticals

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Antibiotic resistance is a global problem and bacterial biofilms contribute to its development. In this context, this study aimed to perform the synthesis and characterization of seven materials based on silica mesoporous nanoparticles functionalized with three types of fluoroquinolones, along with Cu2+ or Ag+ species to evaluate the antibacterial properties against Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, and Pseudomonas aeruginosa, including clinical and multi-drug-resistant strains of S. aureus and P. aeruginosa. In addition, in order to obtain an effective material to promote wound healing, a well-known proliferative agent, phenytoin sodium, was adsorbed onto one of the silver-functionalized materials. Furthermore, biofilm studies and the generation of reactive oxygen species (ROS) were also carried out to determine the antibacterial potential of the synthesized materials. In this sense, the Cu2+ materials showed antibacterial activity against S. aureus and E. coli, potentially due to increased ROS generation (up to 3 times), whereas the Ag+ materials exhibited a broader spectrum of activity, even inhibiting clinical strains of MRSA and P. aeruginosa. In particular, the Ag+ material with phenytoin sodium showed the ability to reduce biofilm development by up to 55% and inhibit bacterial growth in a “wound-like medium” by up to 89.33%.

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Section: Resultscontrasting

confidence: 69%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Antibacterial Properties of Mesoporous Silica Nanoparticles Modified with Fluoroquinolones and Copper or Silver Species

Ugalde-Arbizu,

Aguilera-Correa,

San Sebastian

et al. 2023

Pharmaceuticals

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“…The system showed a promising antibacterial activity against three different planktonic P. aeruginosa strains. These strains are known to have a great facility for generating biofilms; however, the treatment of this silica system obtained very good results in terms of minimal biofilm inhibitory concentration (MBIC) and minimal biofilm eradication concentration (MBEC) values compared to silver NPs alone [120]. Regarding systems based on silica and silver complexes, to the best of our knowledge, to date there is only a single paper by Y. Kuthati et al that reported the preparation of IBN-4 type silica by hydrothermal treatment, loaded with a silver complex via the reaction with a pH-sensitive hydrazone ligand.…”

Section: Silvermentioning

confidence: 99%

Biological Use of Nanostructured Silica-Based Materials Functionalized with Metallodrugs: The Spanish Perspective

Díaz-García

Prashar

Gómez‐Ruiz

2023

IJMS

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Since the pioneering work of Vallet-Regí’s group on the design and synthesis of mesoporous silica-based materials with therapeutic applications, during the last 15 years, the potential use of mesoporous silica nanostructured materials as drug delivery vehicles has been extensively explored. The versatility of these materials allows the design of a wide variety of platforms that can incorporate numerous agents of interest (fluorophores, proteins, drugs, etc.) in a single scaffold. However, the use of these systems loaded with metallodrugs as cytotoxic agents against different diseases and with distinct therapeutic targets has been studied to a much lesser extent. This review will focus on the work carried out in this field, highlighting both the pioneering and recent contributions of Spanish groups that have synthesized a wide variety of systems based on titanium, tin, ruthenium, copper and silver complexes supported onto nanostructured silica. In addition, this article will also discuss the importance of the structural features of the systems for evaluating and modulating their therapeutic properties. Finally, the most interesting results obtained in the study of the potential therapeutic application of these metallodrug-functionalized silica-based materials against cancer and bacteria will be described, paying special attention to preclinical trials in vivo.

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“…In Table 7 , although Sulfamoxole has not been verified in the database, relevant work [ 49 ] has demonstrated its inhibitory activity against E. coli . Similarly, in Table 8 , there is also studies [ 50 , 51 ] proving that Biphenyl and Phenytoin drugs have antibacterial activity against P. aeruginosa . In summary, the proposed model can indeed discover the potential response of microbes to drugs, thereby promoting new treatment options.…”

Section: Experiments Resultsmentioning

confidence: 78%

Joint deep autoencoder and subgraph augmentation for inferring microbial responses to drugs

Zhou,

Zhuo,

et al. 2023

Briefings in Bioinformatics

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Exploring microbial stress responses to drugs is crucial for the advancement of new therapeutic methods. While current artificial intelligence methodologies have expedited our understanding of potential microbial responses to drugs, the models are constrained by the imprecise representation of microbes and drugs. To this end, we combine deep autoencoder and subgraph augmentation technology for the first time to propose a model called JDASA-MRD, which can identify the potential indistinguishable responses of microbes to drugs. In the JDASA-MRD model, we begin by feeding the established similarity matrices of microbe and drug into the deep autoencoder, enabling to extract robust initial features of both microbes and drugs. Subsequently, we employ the MinHash and HyperLogLog algorithms to account intersections and cardinality data between microbe and drug subgraphs, thus deeply extracting the multi-hop neighborhood information of nodes. Finally, by integrating the initial node features with subgraph topological information, we leverage graph neural network technology to predict the microbes’ responses to drugs, offering a more effective solution to the ’over-smoothing’ challenge. Comparative analyses on multiple public datasets confirm that the JDASA-MRD model’s performance surpasses that of current state-of-the-art models. This research aims to offer a more profound insight into the adaptability of microbes to drugs and to furnish pivotal guidance for drug treatment strategies. Our data and code are publicly available at: https://github.com/ZZCrazy00/JDASA-MRD.

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Hybrid Nanosystems Based on Nicotinate-Functionalized Mesoporous Silica and Silver Chloride Nanoparticles Loaded with Phenytoin for Preventing Pseudomonas aeruginosa Biofilm Development

Cited by 8 publications

References 51 publications

Antibacterial Properties of Mesoporous Silica Nanoparticles Modified with Fluoroquinolones and Copper or Silver Species

Antibacterial Properties of Mesoporous Silica Nanoparticles Modified with Fluoroquinolones and Copper or Silver Species

Biological Use of Nanostructured Silica-Based Materials Functionalized with Metallodrugs: The Spanish Perspective

Joint deep autoencoder and subgraph augmentation for inferring microbial responses to drugs

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