Hybrid of 1-deoxynojirimycin and polysaccharide from mulberry leaves treat diabetes mellitus by activating PDX-1/insulin-1 signaling pathway and regulating the expression of glucokinase, phosphoenolpyruvate carboxykinase and glucose-6-phosphatase in alloxan-induced diabetic mice

Li, Yougui; Ji, Dong-Feng; Su, Zhong; Lv, Zhiqiang; Lin, Tao; Chen, Shi; Hu, Gui-Yan

doi:10.1016/j.jep.2011.02.009

Cited by 126 publications

(99 citation statements)

References 35 publications

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“…In fact, this antihyperglycemic action of Persian shallot is likely to be associated with a marked enhancement of the GCK mRNA expression in the liver. Current results is consistent with previous studies that showed GCK mRNA expression increase in Naringin [31], 1-Deoxynojirimycin [33] and epigallocatechin gallate, a main polyphenolic constituent of green tea [34] treated rats.…”

Section: Discussionsupporting

confidence: 93%

“…Our finding suggest that the antioxidants could restore the damaged pancreas and stimulate the secretion of pancreatic insulin meantime; the Persian shallot has probably ability to accelerate the hepatic glucose metabolism may be via regulating the expression of the functional genes of GCK. The results of Real-Time PCR studies provided supportive evidence for FBS analyses [33]. In fact, this antihyperglycemic action of Persian shallot is likely to be associated with a marked enhancement of the GCK mRNA expression in the liver.…”

Section: Discussionsupporting

confidence: 52%

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Persian Shallot (Allium hirtifolium Boiss) Extract Elevates Glucokinase (GCK) Activity and Gene Expression in Diabetic Rats

Mahmoodi¹,

Zarei²,

Rezaeian³

et al. 2013

AJPS

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Hepatic GCK is a key enzyme in glucose homeostasis and, as such, is a potential target for treatment strategies of diabetes. We investigated the effect of Persian shallot (Allium hirtifolium Boiss) hydroalchoholic extract on blood glucose level, plasma insulin level, GCK activity and its gene expression. Thirty two male rats were divided into 4 groups of 8, diabetic groups received 100 and 200 mg/kg Persian shallot extract, diabetic control and normal control received 0.9% saline for 30 days. Investigations of gene expression by Real-Time PCR showed that Persian shallot had led to gently increased GCK gene expression in diabetic rats. GCK activity increased significantly in Persian shallot treated group in dose dependent manner (P < 0.05). These results indicated that Persian shallot exhibited a significant potential as a hypoglycemic agent perhaps via its ability to enhance insulin secretion, GCK gene expression and its activity.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 52%

Persian Shallot (Allium hirtifolium Boiss) Extract Elevates Glucokinase (GCK) Activity and Gene Expression in Diabetic Rats

Mahmoodi¹,

Zarei²,

Rezaeian³

et al. 2013

AJPS

View full text Add to dashboard Cite

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“…Large polymer molecules might be difficult to penetrate to certain extent when using in topical application for the treatment of specific cutaneous herpes simplex virus-1 viral infections, small oligosaccharide polymers such as dextran sulfate have ability to pass through easily from different body barriers. Also these oligosaccharides have shown better diffusion ability in blood when fed in the experimental rats with oral heparin (Li et al, 2011). This study confirmed that oligosaccharide polymers such as dextrans possessing sulfate group might serve as natural alternatives in antiviral therapy leading to proper utilization of these inexpensive polysaccharides found abundantly in nature (Bouhlal et al, 2011).…”

Section: Modes Of Actionsupporting

confidence: 68%

Exopolysaccharide and lactic acid bacteria: Perception, functionality and prospects

Bajpai

Rather

Majumder

et al. 2015

Bangladesh J Pharmacol

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Lactic acid bacteria exhibit the most effective potential to divert significant amount of fermentable sugars towards the biosynthesis of functional exopolysaccharide. Exopolysaccharides from lactic acid bacteria are receiving a renewed interest due to the claims of human health benefits. This review provides an update on multiple uses and production of exopolysaccharides with major emphasis on their chemical properties, characterization, and some other molecular strategies adopted for their genetics and biological tailoring to better understand the process of exopolysaccharide production along with their antiviral efficacy with multiple modes of action. Additionally, microbiological, biochemical, nutritional and biotechnological aspects of exopolysaccharide production have also been discussed. Moreover, appro-priate suggestions have been made on lactic acid bacteria improvements, leading to enhanced production with advanced modification and production process that may contribute to the economic soundness of applications in food and pharmacological industries with this promising group of biomolecules.

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“…Decades ago, it had been found that 1-deoxynojirimycin (DNJ) was one of the alkaloids in mulberry strongly inhibiting α-glucosidase both in vitro and in vivo [44,45]. It was also reported that the hybrid of DNJ and polysaccharide from mulberry leaves may have antidiabetic activity by regulating the expression of the hepatic gluconeogenesis enzymes, glucokinase, phosphoenolpyruvate carboxykinase, and glucose-6-phosphatase [46]. Its analog acarbose has been commercialized and used clinically for many years.…”

Section: Discussionmentioning

confidence: 99%

Mulberry branch bark powder significantly improves hyperglycemia and regulates insulin secretion in type II diabetic mice

Yin

Liu

Zhang

2017

Food & Nutrition Research

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This experiment, based on the previous study on R. mori, introduces whole mulberry branch powder into the diet to treat diabetic mice. Mulberry branch bark powder (MBBP) was administered orally to streptozotocin (STZ)-induced type II diabetic (T2D) mice to investigate hypoglycemic effects. After a 4-week period of diet consumption containing 5%, 10% and 20% MBBP, the fasting blood glucose, body weight and the related western blotting were measured, pathologic and immunohistochemical were observed. The 20% MBBP group showed a significant reduction in hyperglycemia and hyperinsulinemia; fasting blood glucose and insulin decreased from 25.0 to 14.8 mmol/L and 26.5 to 16.0 mU/L, respectively. Pathologic and immunohistochemical observation showed that MBBP administration lead to the repair of pancreas cells and restoration of insulin secretion. Dietary MBBP was associated with the decrease in the contents of 3, 4-methylenedioxeamphetamine, 8-OHdG, aspartate aminotransferase, and alanine aminotransferase, and the increase in antioxidative ability and glucose tolerance. Western blotting (WB) analysis suggested that MBBP decreased the TNF-α levels, thus relieving inflammation and improving liver function. It also led to the downregulation of apoptosis factor expression. WB also confirmed that MBBP enhanced the gene expression of the key enzymes: insulin receptor, insulin receptor substrate, p-AKT, GSK3β, glycogen synthase, G6Pase and phosphoenolpyruvate carboxykinase, which are related to glucose metabolism in the liver, and increase the expression of the genes PDX-1, GLUT2, MafA, and glucokinase, related to insulin secretion. Thus, oral administration of MBBP regulated insulin secretion and effectively maintained normal levels of glucose metabolism in mice, which may be done by improving the antioxidant capacity and activating insulin signaling with T2D..

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Hybrid of 1-deoxynojirimycin and polysaccharide from mulberry leaves treat diabetes mellitus by activating PDX-1/insulin-1 signaling pathway and regulating the expression of glucokinase, phosphoenolpyruvate carboxykinase and glucose-6-phosphatase in alloxan-induced diabetic mice

Cited by 126 publications

References 35 publications

Persian Shallot (<i>Allium hirtifolium</i> Boiss) Extract Elevates Glucokinase (GCK) Activity and Gene Expression in Diabetic Rats

Persian Shallot (<i>Allium hirtifolium</i> Boiss) Extract Elevates Glucokinase (GCK) Activity and Gene Expression in Diabetic Rats

Exopolysaccharide and lactic acid bacteria: Perception, functionality and prospects

Mulberry branch bark powder significantly improves hyperglycemia and regulates insulin secretion in type II diabetic mice

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Hybrid of 1-deoxynojirimycin and polysaccharide from mulberry leaves treat diabetes mellitus by activating PDX-1/insulin-1 signaling pathway and regulating the expression of glucokinase, phosphoenolpyruvate carboxykinase and glucose-6-phosphatase in alloxan-induced diabetic mice

Cited by 126 publications

References 35 publications

Persian Shallot (&lt;i&gt;Allium hirtifolium&lt;/i&gt; Boiss) Extract Elevates Glucokinase (GCK) Activity and Gene Expression in Diabetic Rats

Persian Shallot (&lt;i&gt;Allium hirtifolium&lt;/i&gt; Boiss) Extract Elevates Glucokinase (GCK) Activity and Gene Expression in Diabetic Rats

Exopolysaccharide and lactic acid bacteria: Perception, functionality and prospects

Mulberry branch bark powder significantly improves hyperglycemia and regulates insulin secretion in type II diabetic mice

Contact Info

Product

Resources

About

Persian Shallot (<i>Allium hirtifolium</i> Boiss) Extract Elevates Glucokinase (GCK) Activity and Gene Expression in Diabetic Rats

Persian Shallot (<i>Allium hirtifolium</i> Boiss) Extract Elevates Glucokinase (GCK) Activity and Gene Expression in Diabetic Rats