The main problem with electricity supply on densely populated islands is reliable, low-carbon, and sustainable electricity. The availability of potential energy needs in-depth observation to ensure that the system can be built sustainably. This paper examines the integration of PV systems and diesel power systems on Karimunjawa Island to meet the need for reliable systems from economic, ecological, and technological aspects. Using the DigSilent Power Factory program to obtain the system response interference and penetration of the Photovoltaic (PV) system. Furthermore, this paper also tests short circuit analysis and economic feasibility analysis while validating the Levelized Cost of Electricity (LCOE) and Electric Production Cost (EPC) approaches. The results show that the availability of irradiation can handle the electricity needs on Karimunjawa Island. In addition, it proposes the designed requirements for an integrated PV power system and Diesel Power Plant (DPP) system. The research has also captured the synergistic profile of PV and DPP working coordination within 24 h.