Hybrid PEGylated chitosan/PLGA nanoparticles designed as pH-responsive vehicles to promote intracellular drug delivery and cancer chemotherapy

Huang, Sheng-Jyun; Wang, Tzu‐Hao; Chou, Ya-Hsuan; Wang, Hui‐Min David; Hsu, Tsai‐Ching; Yow, Jia-Le; Tzang, Bor‐Show; Chiang, Wen‐Hsuan

doi:10.1016/j.ijbiomac.2022.04.209

Cited by 42 publications

(15 citation statements)

References 50 publications

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“…ChNPs have very good anticancer properties, which have been confirmed by many researchers [ 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 ]. They have been proven to be toxic to oral cavity [ 28 ], breast [ 29 , 30 , 31 , 32 ], prostate [ 33 , 34 ], glioblastoma [ 35 ], liver [ 36 , 37 ], and colon cancers [ 37 , 38 ], while showing satisfactory biocompatibility with normal developing cells and/or tissues. The main assessment of the anti-cancer effect of the newly formed NPs, apart from the release kinetics, was to obtain a dependence of the release on pH conditions, which is very beneficial in targeted therapy [ 39 ].…”

Section: Introductionmentioning

confidence: 76%

Chitosan-Based Nanoparticles as Effective Drug Delivery Systems—A review

et al. 2023

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Chitosan-based nanoparticles (chitosan-based nanocomposites; chitosan nanoparticles; ChNPs) are promising materials that are receiving a lot of attention in the last decades. ChNPs have great potential as nanocarriers. They are able to encapsulate drugs as well as active compounds and deliver them to a specific place in the body providing a controlled release. In the article, an overview has been made of the most frequently used preparation methods, and the developed applications in medicine. The presentation of the most important information concerning ChNPs, especially chitosan’s properties in drug delivery systems (DDS), as well as the method of NPs production was quoted. Additionally, the specification and classification of the NPs’ morphological features determined their application together with the methods of attaching drugs to NPs. The latest scientific reports of the DDS using ChNPs administered orally, through the eye, on the skin and transdermally were taken into account.

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Section: Introductionmentioning

confidence: 76%

Chitosan-Based Nanoparticles as Effective Drug Delivery Systems—A review

et al. 2023

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“…The straightforward synthesis process, facile self-assembly in aqueous medium, structural stability, high drug loading capacity, and sustained blood circulation are just a few of the special characteristics of polyion complex micelles [ 51 ]. Poly(ethylene oxide)-b-poly(methacrylic acid) (PEO-b-PMA) [ 52 ] and PEG-chitosan [ 53 ] are two of the most popular amphiphilic block copolymers for creating polyion complex micelles.…”

Section: General Issues and Status Quo Of Polymeric Micellesmentioning

confidence: 99%

Polymeric Micellar Systems—A Special Emphasis on “Smart” Drug Delivery

Neguț

Biţă

2023

Pharmaceutics

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Concurrent developments in anticancer nanotechnological treatments have been observed as the burden of cancer increases every year. The 21st century has seen a transformation in the study of medicine thanks to the advancement in the field of material science and nanomedicine. Improved drug delivery systems with proven efficacy and fewer side effects have been made possible. Nanoformulations with varied functions are being created using lipids, polymers, and inorganic and peptide-based nanomedicines. Therefore, thorough knowledge of these intelligent nanomedicines is crucial for developing very promising drug delivery systems. Polymeric micelles are often simple to make and have high solubilization characteristics; as a result, they seem to be a promising alternative to other nanosystems. Even though recent studies have provided an overview of polymeric micelles, here we included a discussion on the “intelligent” drug delivery from these systems. We also summarized the state-of-the-art and the most recent developments of polymeric micellar systems with respect to cancer treatments. Additionally, we gave significant attention to the clinical translation potential of polymeric micellar systems in the treatment of various cancers.

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“…Chitosan Derivative-Based Nanoparticles. Among the various chitosan derivatives, carboxymethyl CS, 87 trimethyl CS, 88 thiolated CS, 89 and PEGylated CS 90 have been extensively investigated in the recent past. Several techniques were employed to synthesize NPs containing chitosan derivatives.…”

Section: Chitosan Derivative-based Nanocarriersmentioning

confidence: 99%

Chitosan Derivatives as Carriers for Drug Delivery and Biomedical Applications

Manna

Seth

Gupta

et al. 2023

ACS Biomater. Sci. Eng.

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Over the past few decades, chitosan (CS) has gained the attention of researchers investigating newer biomaterial-based carriers for drugs in pharmaceutical and biomedical research. Combined with its nontoxic behavior, biodegradability, and biocompatibility, chitosan has found widespread applications in the fields of drug delivery, tissue engineering, and cosmetics. As a novel drug carrier, chitosan is regarded as one of the promising biomaterials in the pharmaceutical industry. The extensive use of this cationic biopolysaccharide in the delivery of therapeutic agents has brought a few limitations of chitosan into the limelight. Various chemical modifications of chitosan can minimize these limitations and improve the efficacy of chitosan as a drug carrier. The effectiveness of several chemically modified chitosan derivatives, including trimethyl chitosan, thiolated chitosan, PEGylated chitosan, and other chitosan derivatives, has been investigated by many researchers for the controlled and target specific delivery of therapeutics. The chemically modified chitosan derivatives exhibited greater importance in the current scenario on drug delivery due to their solubility in wide range of media along with their interaction with pharmaceutically active ingredients. Chitosan derivatives have also attracted attention in several biomedical fields, including wound healing, hyperthermia therapy, tissue engineering, and bioadhesives. The present review narrates the sources and common physicochemical properties of chitosan, including several important synthetic modifications to obtain chemically modified chitosans and their applications in targetspecific drug delivery, along with several biomedical applications.

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Hybrid PEGylated chitosan/PLGA nanoparticles designed as pH-responsive vehicles to promote intracellular drug delivery and cancer chemotherapy

Cited by 42 publications

References 50 publications

Chitosan-Based Nanoparticles as Effective Drug Delivery Systems—A review

Chitosan-Based Nanoparticles as Effective Drug Delivery Systems—A review

Polymeric Micellar Systems—A Special Emphasis on “Smart” Drug Delivery

Chitosan Derivatives as Carriers for Drug Delivery and Biomedical Applications

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