Hybrid PET/MRI in Infection and Inflammation: An Update About the Latest Available Literature Evidence

Kirienko, Margarita; Erba, Paola Anna; Chiti, Arturo; Sollini, Martina

doi:10.1053/j.semnuclmed.2022.10.005

Cited by 14 publications

(2 citation statements)

References 66 publications

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“…Recent studies have particularly focused on application in cardiovascular conditions, with a primary focus on atherosclerosis. The review by Kirienko et al [81] noted a rising trend in publications related to bone and joint diseases from 2018 to 2022. This review confirmed the potential of PET/MRI to have a positive impact on the management of infectious diseases and inflammatory conditions.…”

Section: Fluorine-18-fluorodeoxyglucose (18f-fdg) Pet/mrimentioning

confidence: 99%

Application of Nuclear Medicine Techniques in Musculoskeletal Infection: Current Trends and Future Prospects

Valero-Martínez,

Castillo-Morales,

Gómez-León

et al. 2024

JCM

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Nuclear medicine has become an indispensable discipline in the diagnosis and management of musculoskeletal infections. Radionuclide tests serve as a valuable diagnostic tool for patients suspected of having osteomyelitis, spondylodiscitis, or prosthetic joint infections. The choice of the most suitable imaging modality depends on various factors, including the affected area, potential extra osseous involvement, or the impact of previous bone/joint conditions. This review provides an update on the use of conventional radionuclide imaging tests and recent advancements in fusion imaging scans for the differential diagnosis of musculoskeletal infections. Furthermore, it examines the role of radionuclide scans in monitoring treatment responses and explores current trends in their application. We anticipate that this update will be of significant interest to internists, rheumatologists, radiologists, orthopedic surgeons, rehabilitation physicians, and other specialists involved in musculoskeletal pathology.

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Section: Fluorine-18-fluorodeoxyglucose (18f-fdg) Pet/mrimentioning

confidence: 99%

Application of Nuclear Medicine Techniques in Musculoskeletal Infection: Current Trends and Future Prospects

Valero-Martínez,

Castillo-Morales,

Gómez-León

et al. 2024

JCM

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“…As a future trend, we must also consider that some of the above limits can be overcome by the advent of PET/magnetic resonance imaging (MRI) in clinical practice. PET/MRI, with higher soft-tissue contrast and better-performing PET scanners, will extend the field of molecular imaging to the study of infectious diseases [115], with high sensitivity [116]. This is a necessary step to perform prior to considering, as a further point of reflection, that further imaging probes are under study for the visualization of retroviral infections [117], while 18 F-FDG already plays a role in the detection of tracer-avid lymphadenopathies linked to monkeypox infection in HIV patients [118].…”

Section: Ga-citrate Leukocytes Apoptosismentioning

confidence: 99%

PET/CT Imaging of Infectious Diseases: Overview of Novel Radiopharmaceuticals

Calabria,

Guadagnino,

Cimini

et al. 2024

Diagnostics

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Infectious diseases represent one of the most common causes of hospital admission worldwide. The diagnostic work-up requires a complex clinical approach, including laboratory data, CT and MRI, other imaging tools, and microbiologic cultures. PET/CT with 18F-FDG can support the clinical diagnosis, allowing visualization of increased glucose metabolism in activated macrophages and monocytes; this tracer presents limits in differentiating between aseptic inflammation and infection. Novel PET radiopharmaceuticals have been developed to overcome these limits; 11C/18F-labeled bacterial agents, several 68Ga-labeled molecules, and white blood cells labeled with 18F-FDG are emerging PET tracers under study, showing interesting preliminary results. The best choice among these tracers can be unclear. This overview aims to discuss the most common diagnostic applications of 18F-FDG PET/CT in infectious diseases and, as a counterpoint, to describe and debate the advantages and peculiarities of the latest PET radiopharmaceuticals in the field of infectious diseases, which will probably improve the diagnosis and prognostic stratification of patients with active infectious diseases.

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PET/MRI in practice: a clinical centre survey endorsed by the European Association of Nuclear Medicine (EANM) and the EANM Forschungs GmbH (EARL)

Prakken

Besson

Borra

et al. 2023

Eur J Nucl Med Mol Imaging

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Hybrid PET/MRI in Infection and Inflammation: An Update About the Latest Available Literature Evidence

Cited by 14 publications

References 66 publications

Application of Nuclear Medicine Techniques in Musculoskeletal Infection: Current Trends and Future Prospects

Application of Nuclear Medicine Techniques in Musculoskeletal Infection: Current Trends and Future Prospects

PET/CT Imaging of Infectious Diseases: Overview of Novel Radiopharmaceuticals

PET/MRI in practice: a clinical centre survey endorsed by the European Association of Nuclear Medicine (EANM) and the EANM Forschungs GmbH (EARL)

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