Hybrid photoactive nanomaterial composed of gold nanoparticles, pheophorbide-A and hyaluronic acid as a targeted bimodal phototherapy

Kang, Suk Ho; Nafiujjaman,; Nurunnabi, Md; Li, Li; Khan, Haseeb A.; Cho, Kwang Jae; Huh, Kang Moo; Lee, Yong-Kyu

doi:10.1007/s13233-015-3061-x

Cited by 37 publications

(20 citation statements)

References 33 publications

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“…After the advent of nanotechnology, there is a growing trend about the design, synthesis, and use of engineered nanoparticles (NPs) in different areas including medicine, cosmetics, coating, bioremediation, paints, electronics, and the food industry [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 ]. Recently, gold nanoparticles (GNPs) have been regarded as promising candidates for optical sensors, imaging, drug delivery, and therapeutic applications due to their size- and shape-dependent physical properties and their inherent biocompatibility compared with other metallic nanoparticles [ 9 , 10 , 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Histopathology of the Liver, Kidney, and Spleen of Mice Exposed to Gold Nanoparticles

et al. 2018

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Gold nanoparticles (GNPs) are biocompatible nanomaterials that are currently researched for biomedical applications such as imaging and targeted drug delivery. In this investigation, we studied the effects of a single dose (injected on day 1) as well as a priming dose (two injections with a gap of one week) of 5 nm, 20 nm, and 50 nm diameter GNPs on the structural and biochemical changes in the liver, kidney, and spleen of mice. The results showed that small sized GNPs (5 nm) produced significant pathological changes in the liver on day 2 that gradually reduced on day 8. The medium (20 nm) and large (50 nm) sized GNPs preferentially targeted the spleen and caused significant pathological changes to the spleen architecture on day 2 that persisted on day 8 as well. There were minimal and insignificant pathological changes to the kidneys irrespective of the GNPs size. The animals that were primed with the pre-exposure of GNPs did not show any aggravation of histological changes after the second dose of the same GNPs. None of the dose regimens of the GNPs were able to significantly affect the markers of oxidative stress including glutathione (GSH) and malondialdehyde (MDA) in all of the organs that were studied. In conclusion, the size of GNPs plays an important role in their pathological effects on different organs of mice. Moreover, the primed animals become refractory to further pathological changes after the second dose of GNPs, suggesting the importance of a priming dose in medical applications of GNPs.

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Section: Introductionmentioning

confidence: 99%

Histopathology of the Liver, Kidney, and Spleen of Mice Exposed to Gold Nanoparticles

et al. 2018

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“…Furthermore, tumor specificity and therapeutic efficacy in tumor-bearing mice were significantly increased [81]. On the other hand, HA-Au NPs can be used as protein drug delivery carriers.…”

Section: Ha-coated Au Npsmentioning

confidence: 99%

Hyaluronic Acid-Based Theranostic Nanomedicines for Targeted Cancer Therapy

Lee

Kang

Jeong

et al. 2020

Cancers

104

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Hyaluronic acid (HA) is a natural mucopolysaccharide and has many useful advantages, including biocompatibility, non-immunogenicity, chemical versatility, non-toxicity, biodegradability, and high hydrophilicity. Numerous tumor cells overexpress several receptors that have a high binding affinity for HA, while these receptors are poorly expressed in normal body cells. HA-based drug delivery carriers can offer improved solubility and stability of anticancer drugs in biological environments and allow for the targeting of cancer treatments. Based on these benefits, HA has been widely investigated as a promising material for developing the advanced clinical cancer therapies in various formulations, including nanoparticles, micelles, liposomes, and hydrogels, combined with other materials. We describe various approaches and findings showing the feasibility of improvement in theragnosis probes through the application of HA.

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“…26 Cell viability was normalized to control cells with no drug and no laser irradiation. A549 cells were incubated with both Ce6 and GQD-HA-Ce6 nanoparticles for 24 h followed by irradiation with a 5 mW cm ¹2 laser (670 nm) for 5 min.…”

Section: ¹1mentioning

confidence: 99%

Enhanced Photodynamic Properties of Graphene Quantum Dot Conjugated Ce6 Nanoparticles for Targeted Cancer Therapy and Imaging

Nafiujjaman¹,

Revuri²,

Park³

et al. 2016

Chem. Lett.

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In this study, we report the enhanced photodynamic therapeutic (PDT) activity of Chlorin e6 (Ce6)-loaded graphene quantum dots (GQDs). GQDs reinforced the Ce6 loading, solubility, and fluorescence in aqueous media and enhanced ROS production and cancer cell death. This GQDs conjugated Ce6 could be a good platform for imaging-guided cancer therapy. Keywords: Graphene quantum dot (GQD) | Photodynamic therapy | Reactive oxygen species (ROS)Photodynamic therapy (PDT) is a light-sensitive cancer therapy that employs the cooperative interactions between light and photosensitizer (PS) to generate reactive oxygen species (ROS) and promote tumor suppression.1 In general, PDT involves in the systemic, local, or topical administration of a nontoxic drug or dye known as PS at the targeted site, followed by selective illumination with the appropriate wavelength and power of light.2,3 During this process, PS absorbs the appropriate wavelength of light and reaches the excited state. While returning to the ground state, PS transfers its energy to the local oxygen molecules and aids in the production of ROS. The ROS thus produced can activate pro apoptotic signals and aid in programmed cancer cell death and complete tumor destruction. 4 In particular, the second-generation PS like Chlorin e6 (Ce6) have gained significant attention in PDT as they possess high ROS production activity with minimal dark toxicity.5 However, the poor biological stability, undesirable pharmacokinetics, non-specific biodistribution, and lack of targeting specificity of Ce6 impede their applications to clinical settings.6 Several carriers including iron oxide nanoclusters, 7 gold nanoparticles, 8 graphene oxide, 4 graphene quantum dots, 9 and silica nanoparticles have been used to improve the stability and therapeutic outcomes of these PS. Chen et al. introduced the concept of photodynamic molecular beacon where 1 O 2 quencher and PS are placed in close proximity by conjugating to the diseasespecific linker and combined the two principles of fluorescence resonance energy transfer and photodynamic therapy. Graphene quantum dots (GQDs) are 0D nanomaterials that gained significant attention in imaging-guided cancer therapy. Their quantum confinement and edge effect characteristics imparted GQDs with enhanced photostability, tunable photoluminescence, and electrochemiluminescence properties. 1113 Moreover, these materials are biocompatible, non-toxic, and can easily be functioned with diverse drug and biomolecules.14 In addition, GQDs possess higher surface area and have the ability to initiate ππ interactions with the aromatic drug molecules and improve their aqueous stability and solubility.1517 Nanosized GQDs can not only accumulate in the tumor site, generating ROS via a multistage sensitization process, but also generate photothermal properties and promote tumor suppression. 18Here, we first conjugated Ce6 to hyaluronic acid (HA) and further loaded over GQDs to develop targeted, imaging-guided photodynamic therapy to treat cancer (Scheme 1). HA is a ...

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Hybrid photoactive nanomaterial composed of gold nanoparticles, pheophorbide-A and hyaluronic acid as a targeted bimodal phototherapy

Cited by 37 publications

References 33 publications

Histopathology of the Liver, Kidney, and Spleen of Mice Exposed to Gold Nanoparticles

Histopathology of the Liver, Kidney, and Spleen of Mice Exposed to Gold Nanoparticles

Hyaluronic Acid-Based Theranostic Nanomedicines for Targeted Cancer Therapy

Enhanced Photodynamic Properties of Graphene Quantum Dot Conjugated Ce6 Nanoparticles for Targeted Cancer Therapy and Imaging

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