Hybrid polymeric therapeutic microcarriers for thermoplasmonic-triggered release of resveratrol

Stoia, Daria; Pop, Roxana; Campu, Andreea; Nistor, Mădălina; Aştilean, Simion; Pintea, Adela; Suciu, Maria; Rugină, Dumitriţa; Focșan, Monica

doi:10.1016/j.colsurfb.2022.112915

Cited by 8 publications

(4 citation statements)

References 35 publications

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“…When rutin was conjugated with AuNPs, these nanoparticles (AuNPsR) showed higher oral bioavailability with increased antioxidant capacity and the function to improve the fundus appearance of retinal arterioles [ 193 ]. Stoia et al utilized the strengths of the active anisotropic gold bipyramidal nanoparticles (AuBPs) as efficient photothermal agents and fabricated a resveratrol-encapsulated nanocarrier with a calcium carbonate core (CaCO 3 MC-AuBPs) [ 194 ]. CaCO 3 MC-AuBPs are of great interest in treating retinal diseases like DR as they process the power of the controlled release of therapeutic resveratrol based on the laser-induced thermoplasmonic effect at the retinal level [ 194 ].…”

Section: Delivery Systemsmentioning

confidence: 99%

Nutraceuticals for Diabetic Retinopathy: Recent Advances and Novel Delivery Systems

Ye,

Fung,

Lam

et al. 2024

Nutrients

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Diabetic retinopathy (DR) is a major vision-threatening disease among the working-age population worldwide. Present therapeutic strategies such as intravitreal injection of anti-VEGF and laser photocoagulation mainly target proliferative DR. However, there is a need for early effective management in patients with early stage of DR before its progression into the more severe sight-threatening proliferative stage. Nutraceuticals, natural functional foods with few side effects, have been proposed to be beneficial in patients with DR. Over the decades, many studies, either in vitro or in vivo, have demonstrated the advantages of a number of nutraceuticals in DR with their antioxidative, anti-inflammatory, neuroprotective, or vasoprotective effects. However, only a few clinical trials have been conducted, and their outcomes varied. The low bioavailability and instability of many nutraceuticals have indeed hindered their utilization in clinical use. In this context, nanoparticle carriers have been developed to deliver nutraceuticals and to improve their bioavailability. Despite its preclinical nature, research of interventive nutraceuticals for DR may yield promising information in their clinical applications.

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Section: Delivery Systemsmentioning

confidence: 99%

Nutraceuticals for Diabetic Retinopathy: Recent Advances and Novel Delivery Systems

Ye,

Fung,

Lam

et al. 2024

Nutrients

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“…Another fluorescent dye, fluorescein isothiocyanate, was introduced inside near-infrared (NIR) responsive polymeric microcapsules carrying resveratrol in tandem with gold nanobipyramids to observe the internalization process in D407 cells. These microcarriers, with a diameter of 2.5 μm, were able to release the therapeutic agent and showed no cytotoxicity towards the tested cells [ 218 ].…”

Section: Resveratrol Delivery Systemsmentioning

confidence: 99%

Resveratrol: Its Path from Isolation to Therapeutic Action in Eye Diseases

et al. 2022

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Due to the confirmed therapeutic potential of resveratrol (Rv) for eye diseases, namely its powerful anti-angiogenic and antioxidant effects, this molecule must be studied more deeply. Nowadays, the pharmaceutic and pharmacokinetic available studies offer a troubling picture because of its low stability and bioavailability. To overcome this problem, researchers started to design and create different delivery systems that could improve the delivery amount of Rv. Therefore, this review aims to shed light on the proper and efficient techniques to isolate, purify and quantify the Rv molecule, and how this therapeutic molecule can be a part of a delivery system. The Rv great impact on aspects regarding its stability, bioavailability and absorption are also debated here, based on the existent literature on in vitro and in vivo human and animal studies. Moreover, after its absorption the Rv influence at the molecular level in ocular pathologies is described. In addition, the present review summarizes the available literature about Rv, hoping that Rv will gain more attention to investigate its unexplored side.

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“…A hybrid polymeric microcarrier with gold bipyramidal nanoparticles has, e.g., been used to release a therapeutic molecule for diabetic retinopathy upon NIR irradiation. 90 Combination therapy, in which the discussed thermoplasmonic effects are used for both on-site delivery of drugs or genetic material and simultaneous heat-induced hyperthermia, has been proven to be an effective strategy for combating cancer cells. 91,92 There are several advantages of this approach, including the sensitivity of cancer cells to heat and the stronger therapeutic effect of some drugs at higher temperatures.…”

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confidence: 99%

“…There are two generic approaches for using thermoplasmonics in drug delivery: (i) conjugating drugs directly to the surface of nanoparticles, such that the drug will be released when irradiation causes heating of the system (Figure C), and (ii) employing a thermosensitive drug container made from, e.g., hydrogels or lipids, to release the content , (Figure D). A hybrid polymeric microcarrier with gold bipyramidal nanoparticles has, e.g., been used to release a therapeutic molecule for diabetic retinopathy upon NIR irradiation . Combination therapy, in which the discussed thermoplasmonic effects are used for both on-site delivery of drugs or genetic material and simultaneous heat-induced hyperthermia, has been proven to be an effective strategy for combating cancer cells. , There are several advantages of this approach, including the sensitivity of cancer cells to heat and the stronger therapeutic effect of some drugs at higher temperatures.…”

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confidence: 99%

Biological Applications of Thermoplasmonics

Ruhoff,

Arastoo,

Moreno-Pescador

et al. 2024

Nano Lett.

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Thermoplasmonics has emerged as an extraordinarily versatile tool with profound applications across various biological domains ranging from medical science to cell biology and biophysics. The key feature of nanoscale plasmonic heating involves remote activation of heating by applying laser irradiation to plasmonic nanostructures that are designed to optimally convert light into heat. This unique capability paves the way for a diverse array of applications, facilitating the exploration of critical biological processes such as cell differentiation, repair, signaling, and protein functionality, and the advancement of biosensing techniques. Of particular significance is the rapid heat cycling that can be achieved through thermoplasmonics, which has ushered in remarkable technical innovations such as accelerated amplification of DNA through quantitative reverse transcription polymerase chain reaction. Finally, medical applications of photothermal therapy have recently completed clinical trials with remarkable results in prostate cancer, which will inevitably lead to the implementation of photothermal therapy for a number of diseases in the future. Within this review, we offer a survey of the latest advancements in the burgeoning field of thermoplasmonics, with a keen emphasis on its transformative applications within the realm of biosciences.

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Hybrid polymeric therapeutic microcarriers for thermoplasmonic-triggered release of resveratrol

Cited by 8 publications

References 35 publications

Nutraceuticals for Diabetic Retinopathy: Recent Advances and Novel Delivery Systems

Nutraceuticals for Diabetic Retinopathy: Recent Advances and Novel Delivery Systems

Resveratrol: Its Path from Isolation to Therapeutic Action in Eye Diseases

Biological Applications of Thermoplasmonics

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