Hybrid Reaction Systems for the Synthesis of Alkylated Compounds Based upon Cu‐Catalyzed Coupling of Radicals and Organometallic Species

Abstract

A transition metal catalyzed alkylation with an alkyl halide is one of the most difficult reactions to achieve, because of the difficult oxidative addition of an alkyl-halogen bond to a metal, and the strong tendency of the resulting alkylmetal intermediate to undergo a β-hydride elimination reaction to give an olefin. In this review, we discuss hybrid reaction systems involving Cu catalyzed combination of radical and organometallic species, which enable facile alkylation reactions to construct C-C and Cheteroatom bonds. This paper highlights recent arylation, alkenylation, alkynylation, cyclization, addition and introduction of heteroatoms via these hybrid reaction systems.