Hybrid silica nanoparticles traceable by fluorescence and FT-IR spectroscopy: preparation, characterization and preliminary biological studies

Alesker, Maria; Heller, Adi; Malik, Zvi; Makarovsky, Igor; Lellouche, Jean‐Paul

doi:10.1039/c1jm11555c

Cited by 9 publications

(5 citation statements)

References 41 publications

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“…All samples have strong bands located at around 460 ( O-Si-O ), 1100 ( asym.Si-O-Si ), and 3300-3500 cm −1 ( Si-OH ), confirming the presence of the SiO 2 inorganic phase [31]. The -NH 2 functionalization was clearly evidenced by the bands detected at around 1500 cm −1 and 3000 cm −1 , which were unambiguously attributed to the NH bending vibration and C-N stretching vibration, respectively [20,[31][32][33][34]. Similarly, -CN and -COOH functionalizations were proved by the observation of relative characteristic peaks.…”

Section: Modification Of Hmsnsmentioning

confidence: 59%

Functionalization of Hollow Mesoporous Silica Nanoparticles for Improved 5‐FU Loading

She

Chen

et al. 2015

Journal of Nanomaterials

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Hollow mesoporous silica nanoparticles were successfully fabricated and functionalized with appropriate silanes. After modifications, amine, carboxyl, cyano, and methyl groups were grafted onto the nanoparticles and all functionalized hollow mesoporous silica nanoparticles maintained a spherical and hollow structure with a mean diameter of ~120 nm and a shell thickness of ~10 nm. The loading capacity of the hollow mesoporous silica nanoaprticles to the anticancer drug, 5-fluorouracil, can be controlled via precise functionalization. The presence of amine groups on the surface of nanoparticles resulted in the highest loading capacity of 28.89%, due to the amine functionalized nanoparticles having a similar hydrophilicity but reverse charge to the drug. In addition, the change in pH leads to the variation of the intensity of electrostatic force between nanoparticles and the drug, which finally affects the loading capacity of amine functionalized hollow mesoporous silica nanoparticles to some extent. Higher drug loading was observed at pH of 7.4 and 8.5 as 5-fluorouracil becomes more deprotonated in alkaline conditions. The improved drug loading capacity by amine functionalized hollow mesoporous silica nanoparticles has demonstrated that they can become potential intracellular 5-fluorouracil delivery vehicles for cancers.

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Section: Modification Of Hmsnsmentioning

confidence: 59%

Functionalization of Hollow Mesoporous Silica Nanoparticles for Improved 5‐FU Loading

She

Chen

et al. 2015

Journal of Nanomaterials

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“…The remaining ethoxy groups following the Stöber reaction of tetraethyl orthosilicate (TEOS) can clearly be observed in the FTIR spectra of the SiO 2 particles, that is, the CH 2 /CH 3 bending absorbance band at 1452 cm –1 and the CH 2 /CH 3 absorbance band at 2980 cm –1 . Following hydrolysis to obtain SiO 2 NPs with surface −OH functionalities (SiO 2 -OH), these absorbance bands disappeared, which indicates quantitative hydrolysis of the ethoxy groups . The reappearance of the bands at 2980, 1450, and 1380 cm –1 in the FTIR spectrum of amino-functionalized NPs (SiO 2 -NH 2 ) indicates the successful surface modification with NH 2 groups.…”

Section: Results and Discussionmentioning

confidence: 94%

“… 49 Following hydrolysis to obtain SiO 2 NPs with surface −OH functionalities (SiO 2 -OH), these absorbance bands disappeared, which indicates quantitative hydrolysis of the ethoxy groups. 50 The reappearance of the bands at 2980, 1450, and 1380 cm –1 in the FTIR spectrum of amino-functionalized NPs (SiO 2 -NH 2 ) indicates the successful surface modification with NH 2 groups. This indication is strengthened by the fact that the SiO 2 -NH 2 NPs resulted in a positive ninhydrin color test, 51 confirming the presence of NH 2 groups on these particles.…”

Section: Results and Discussionmentioning

confidence: 99%

Silica-Assisted Nucleation of Polymer Foam Cells with Nanoscopic Dimensions: Impact of Particle Size, Line Tension, and Surface Functionality

Liu

Eijkelenkamp

Duvigneau

et al. 2017

ACS Appl. Mater. Interfaces

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Core–shell nanoparticles consisting of silica as core and surface-grafted poly(dimethylsiloxane) (PDMS) as shell with different diameters were prepared and used as heterogeneous nucleation agents to obtain CO2-blown poly(methyl methacrylate) (PMMA) nanocomposite foams. PDMS was selected as the shell material as it possesses a low surface energy and high CO2-philicity. The successful synthesis of core–shell nanoparticles was confirmed by Fourier transform infrared spectroscopy, thermogravimetric analysis, and transmission electron microscopy. The cell size and cell density of the PMMA micro- and nanocellular materials were determined by scanning electron microscopy. The cell nucleation efficiency using core–shell nanoparticles was significantly enhanced when compared to that of unmodified silica. The highest nucleation efficiency observed had a value of ∼0.5 for nanoparticles with a core diameter of 80 nm. The particle size dependence of cell nucleation efficiency is discussed taking into account line tension effects. Complete engulfment by the polymer matrix of particles with a core diameter below 40 nm at the cell wall interface was observed corresponding to line tension values of approximately 0.42 nN. This line tension significantly increases the energy barrier of heterogeneous nucleation and thus reduces the nucleation efficiency. The increase of the CO2 saturation pressure to 300 bar prior to batch foaming resulted in an increased line tension length. We observed a decrease of the heterogeneous nucleation efficiency for foaming after saturation with CO2 at 300 bar, which we attribute to homogenous nucleation becoming more favorable at the expense of heterogeneous nucleation in this case. Overall, it is shown that the contribution of line tension to the free energy barrier of heterogeneous foam cell nucleation must be considered to understand foaming of viscoelastic materials. This finding emphasizes the need for new strategies including the use of designer nucleating particles to enhance the foam cell nucleation efficiency.

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“…The bands are sharper with increased g-C 3 N 4 content. Thus, the bands of SiO 2 at 1050 cm -1 originated from Si-O-Si [35] are getting subtle with large amounts of g-C 3 N 4 . In addition, the characteristic Raman spectra of hybrid hydrogels are similar to that of pure 11 g-C 3 N 4 [36] (Figure S8).…”

Section: Resultsmentioning

confidence: 99%

Separation free C3N4/SiO2 hybrid hydrogels as high active photocatalysts for TOC removal

Zhang

Luo

Wei

et al. 2016

Applied Catalysis B: Environmental

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The separation free graphitic carbon nitride/SiO 2 (C 3 N 4 /SiO 2) hybrid hydrogels with three-dimensional (3D) network structures have been prepared via alkali-solution and acid-gel process. The hybrid hydrogels perform enhanced ability to absorb and in-situ degrade refractory organic pollutants, such as coking wastewater and phenol. Due to the 3D network structures of C 3 N 4 /SiO 2 hybrid hydrogels, they show efficient pollutants removal ability by synergistic effect of adsorption and in-situ photocatalytic degradation. The total organic carbon content (TOC) of coking wastewater is reduced by 33% with C 3 N 4 /SiO 2 hybrid hydrogel, which is 5 times of pure g-C 3 N 4. The removal abilities of phenol and methylene blue (MB) via hybrid hydrogels are 3.1 and 6 times of pure g-C 3 N 4 respectively. The 3D network structures guarantee C 3 N 4 /SiO 2 hybrid hydrogels to be continuously used without adsorption saturation and separation from water, avoiding the photocatalysts aggregation and secondary pollution.

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Hybrid silica nanoparticles traceable by fluorescence and FT-IR spectroscopy: preparation, characterization and preliminary biological studies

Cited by 9 publications

References 41 publications

Functionalization of Hollow Mesoporous Silica Nanoparticles for Improved 5‐FU Loading

Functionalization of Hollow Mesoporous Silica Nanoparticles for Improved 5‐FU Loading

Silica-Assisted Nucleation of Polymer Foam Cells with Nanoscopic Dimensions: Impact of Particle Size, Line Tension, and Surface Functionality

Separation free C3N4/SiO2 hybrid hydrogels as high active photocatalysts for TOC removal

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