Hybrid silver(I) coumarin-carbene and coumarin-triphenylphosphine complexes: Towards more effective antimicrobial therapies

Mooney, Erika; Tacke, Matthias; Müller-Bunz, Helge; Bruno-Colmenárez, Julia; Cooke, Gordon; Caraher, Emma; Kelleher, Fintan; Creaven, Bernadette S.

doi:10.1016/j.ica.2024.122222

Inorganica Chimica Acta

2024

DOI: 10.1016/j.ica.2024.122222

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Hybrid silver(I) coumarin-carbene and coumarin-triphenylphosphine complexes: Towards more effective antimicrobial therapies

Erika Mooney,

Matthias Tacke,

Helge Müller-Bunz

et al.

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Heteroleptic Coumarin-Based Silver(I) Complexes: Possible New Antimicrobial Agents

Mooney,

Twamley,

Cooke

et al. 2024

Molecules

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Heteroleptic coumarin-based silver(I) complexes with improved solubility profiles were synthesised using either triphenylphosphine or an N-heterocyclic carbene as adduct ligands, and were fully characterised using IR and NMR spectroscopy, elemental analysis, and, where possible, X-ray crystallography. The triphenylphosphine adducts formed well-resolved structures, where the oxyacetate ligands asymmetrically chelated the silver(I) ion in a bidentate chelating mode, and the silver(I) ion was also bound to two triphenylphosphine ligands. The solubility profile and photostability of the adducts were considerably improved compared to those of previously isolated simple coumarin silver(I) complexes. Analysis of the coumarin N-heterocyclic carbene(NHC) silver(I) adduct indicated that it likely formed as a complex aggregate species with an overall stoichiometry of 1:1:1 coumarin:Ag(I):NHC. The Kirby Bauer assay and broth microdilution assays were used to assess the silver(I) complexes’ and adducts’ antimicrobial activity against pathogenic strains of Pseudomonas aeruginosa, Escherichia coli, and MRSA. Interestingly, the formation of more soluble complexes did not increase the activity of the silver(I) complexes and, in effect, made them less effective antimicrobial agents, particularly against Escherichia coli and Pseudomonas aeruginosa, although they retained their activity against MRSA.

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Heteroleptic Coumarin-Based Silver(I) Complexes: Possible New Antimicrobial Agents

Mooney,

Twamley,

Cooke

et al. 2024

Molecules

View full text Add to dashboard Cite

show abstract

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Hybrid silver(I) coumarin-carbene and coumarin-triphenylphosphine complexes: Towards more effective antimicrobial therapies

Cited by 1 publication

References 61 publications

Heteroleptic Coumarin-Based Silver(I) Complexes: Possible New Antimicrobial Agents

Heteroleptic Coumarin-Based Silver(I) Complexes: Possible New Antimicrobial Agents

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