Hybrid Single-Photon Emission Computed Tomography/Computed Tomography Imaging Features of Tumoral Calcinosis in Technetium-99m Methylene Diphosphonate Bone Scintigraphy

Abstract

Tumoral calcinosis (TC) is an uncommon ectopic calcification syndrome. TC is a benign condition characterized by the presence of large calcific soft tissue deposits occurring predominantly in a periarticular location. It generally occurs as a complication of renal dialysis or trauma, and is rarely seen in familial and sporadic cases. Bone scintigraphy is a sensitive method for diagnosing TC. We report a case of year old female with. She underwent bone scintigraphy to see the sites of involvement, which showed intense foci of tracer activity in soft tissue in bilateral thigh and gluteal region. Hybrid single-photon emission computed tomography/computed tomography of the pelvis and thigh localized tracer uptake to the calcification in the gluteal and thigh region.

Additional Value of 99mtc-mdp Single-photon Emission Computed Tomography-computed Tomography for Detection and Characterization of Bone Lesions in Nasopharyngeal Carcinoma Patients

“…For the vertebrae where the location of a lesion determines whether it is classi ed as malignant or benign. The study shows that most of the benign lesions were within the facet joints or at the end plate of the vertebral bodies whereas the malignant lesions were predominantly within the pedicles and vertebral bodies [12] . The management of a patient mostly based on diagnosis and clinical staging.…”

Multiple uremic tumoral calcinosis in periarticular soft tissues with chronic renal failure: a case report

“…T1WI and T2WI by MRI generally show inhomogeneous high signal intensity and can clearly show sedimentation signs, representing solid, cystic, and fibrous elements with areas of hemorrhage ( 9 ). Potential mechanisms underlying the high metabolic lesions detected by SPECT may involve extracellular fluid dilation, heightened local vascular permeability, compromised lymphatic or venous clearance in the affected region, and elevated tissue calcium concentrations ( 10 ). These mechanisms may collectively provide valuable information about the active state of the lesion.…”