Nanoparticles, which are particles with dimensions on the nanoscale, have a wide range of applications across many different fields. Nanoparticles are used in many fields, such as electronics, medicine, cosmetics, manufacturing, and materials science. They have unique properties such as a high surface area-to-volume ratio, high reactivity, and the ability to interact with biological systems. In this chapter, the applications and effects of nanoparticles in conventional—Lathe, Grinding, Milling, and drilling processes—and unconventional machining processes—electro-chemical machining, electro-discharge, ultrasonic, abrasive waster-jet machining—processes are illustrated. Special applications of nanoparticles in medicine, agriculture, food, construction, biotechnology, and IC engines have also been discussed. The limitations of using nanoparticles in engineering applications have also been explained.