Hybrid systems combining liposomes and entangled hyaluronic acid chains: Influence of liposome surface and drug encapsulation on the microstructure

Jaudoin, Céline; Grillo, Isabelle; Cousin, Fabrice; Gehrke, M.; Ouldali, Malika; Arteni, Ana-Andreea; PICTON, Luc; RIHOUEY, Christophe; Bochot, Amélie; AGNELY, Florence

doi:10.1016/j.jcis.2022.07.146

Cited by 5 publications

(2 citation statements)

References 47 publications

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“…Clustering and hard-core interactions between liposomes were readily revealed by SANS as the scattering curves deviated from the ones of vesicles at low Q. The Guinier plateau gave place to a power-law with characteristic exponents of mass fractals and correlation peaks of hard-spheres interactions [ 28 ]. HA has been also studied in combination with vesicles of dipalmitoylphosphatidylcholine (DPPC) with SANS.…”

Section: Application Of Small Angle Neutron Scattering On Nanostructu...mentioning

confidence: 99%

Advances in Small Angle Neutron Scattering on Polysaccharide Materials

Fanova,

Sotiropoulos,

Radulescu

et al. 2024

Polymers

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Polysaccharide materials and biomaterials gain the focus of intense research owing to their great versatility in chemical structures and modification possibilities, as well as their biocompatibility, degradability, and sustainability features. This review focuses on the recent advances in the application of SANS on polysaccharide systems covering a broad range of materials such as nanoparticulate assemblies, hydrogels, nanocomposites, and plant-originating nanostructured systems. It motivates the use of SANS in its full potential by demonstrating the features of contrast variation and contrast matching methods and by reporting the methodologies for data analysis and interpretation. As these soft matter systems may be organized in multiple length scales depending on the interactions and chemical bonds between their components, SANS offers exceptional and unique opportunities for advanced characterization and optimization of new nanostructured polysaccharide materials.

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Section: Application Of Small Angle Neutron Scattering On Nanostructu...mentioning

confidence: 99%

Advances in Small Angle Neutron Scattering on Polysaccharide Materials

Fanova,

Sotiropoulos,

Radulescu

et al. 2024

Polymers

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“…This work provides a strategy for regulating the external charges of nanoparticles and obtaining pH-sensitive nanocarriers, which provide therapeutic nanocarriers for gene therapy, cancer, and vaccines. It developed a variety of liposomal nanoparticles with different external charges by using cationic chitosan and anionic hyaluronic acid rather than changing the ratios of cationic, neutral, or anionic phospholipid molecules . The protonation of the amino group in chitosan features a positive charge of liposomes in acidic conditions, and the deprotonation of the carboxyl group in hyaluronate brings a negative charge for liposomes in an alkaline environment.…”

Section: Introductionmentioning

confidence: 99%

Simply and Cheaply Prepared Liposomal Membrane for Nanocarriers: High Encapsulation Efficiency Based on Broad Regulation of Surface Charges and pH-Switchable Performance

Wu,

Zhang,

Yuan

et al. 2023

Biomacromolecules

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The zeta potential of nanoparticles impacts their distribution and metabolism in the body as well as their interaction with medications of varying charges, hence altering therapeutic efficacy and safety. In this paper, the external charges of liposomes were regulated by utilizing a simple and economical method based on competition for protons of cationic chitosan (CS) and anion hyaluronic acid (HA). The charge regulation of a liposomal membrane is generally accomplished by adjusting the ratio of charged lipids within a liposome (e.g., cationic DOTAP or anionic DOPS), the stability of which was maintained by the coating materials of cationic chitosan (CS) or anion hyaluronic acid (HA). A series of nanoparticles could respond to pH-stimulation with adjustable surface charge. Moreover, the sizes of liposomes coated with CS and HA remain within a narrow range. In vitro cytotoxicity tests revealed that the nanocarriers were safe, and the nanoparticles containing antitumor medicines were efficient in tumor therapy. Considering liposomes with different external surface charges could be aimed at diverse therapy purposes. The strategies for regulating liposomal surface charges with high encapsulation rates and certain release cycles reported here could provide a versatile platform as carriers for the delivery of drugs and other macromolecules into human bodies.

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