Hybrid ultrasound and single wavelength optoacoustic imaging reveals muscle degeneration in peripheral artery disease

Träger, Anna P.; Günther, Josefine S.; Raming, Roman; Paulus, Lars-Philip; Lang, Werner; Meyer, Alexander; Kempf, Julius; Caranovic, Milenko; Li, Yi; Wagner, Alexandra L.; Tan, Lina; Danko, Vera; Trollmann, Regina; Woelfle, Joachim; Klett, Daniel; Neurath, Markus F.; Regensburger, Adrian P.; Eckstein, Markus; Uter, Wolfgang; Uder, Michael; Herrmann, Yvonne; Waldner, Maximilian J.; Knieling, Ferdinand; Rother, Ulrich

doi:10.1016/j.pacs.2023.100579

Cited by 8 publications

(2 citation statements)

References 47 publications

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“… 71–73 So far, various OAI techniques have been explored in dermatological, 74 75 metabolic, 76 gastrointestinal 77–79 and musculoskeletal diseases. 80–83 …”

Section: Fluoro-d-glucose-pet/ctmentioning

confidence: 99%

“…[71][72][73] So far, various OAI techniques have been explored in dermatological, 74 75 metabolic, 76 gastrointestinal [77][78][79] and musculoskeletal diseases. [80][81][82][83] MSOT is a technique that combines ultrasound and multi-wavelength OAI. (NO_PRINTED_FORM) Therefore, MSOT offers a non-invasive in vivo approach for imaging clinically relevant structures and deriving information for individual light-absorbing target molecules (ie, chromophores).…”

Section: Macrophage-targeted Pet/ctmentioning

confidence: 99%

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Metabolic and molecular imaging in inflammatory arthritis

Noversa de Sousa,

Tascilar,

Corte

et al. 2024

RMD Open

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It is known that metabolic shifts and tissue remodelling precede the development of visible inflammation and structural organ damage in inflammatory rheumatic diseases such as the inflammatory arthritides. As such, visualising and measuring metabolic tissue activity could be useful to identify biomarkers of disease activity already in a very early phase. Recent advances in imaging have led to the development of so-called ‘metabolic imaging’ tools that can detect these changes in metabolism in an increasingly accurate manner and non-invasively.Nuclear imaging techniques such as18F-D-glucose and fibroblast activation protein inhibitor-labelled positron emission tomography are increasingly used and have yielded impressing results in the visualisation (including whole-body staging) of inflammatory changes in both early and established arthritis. Furthermore, optical imaging-based bedside techniques such as multispectral optoacoustic tomography and fluorescence optical imaging are advancing our understanding of arthritis by identifying intra-articular metabolic changes that correlate with the onset of inflammation with high precision and without the need of ionising radiation.Metabolic imaging holds great potential for improving the management of patients with inflammatory arthritis by contributing to early disease interception and improving diagnostic accuracy, thereby paving the way for a more personalised approach to therapy strategies including preventive strategies. In this narrative review, we discuss state-of-the-art metabolic imaging methods used in the assessment of arthritis and inflammation, and we advocate for more extensive research endeavours to elucidate their full field of application in rheumatology.

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“… 71–73 So far, various OAI techniques have been explored in dermatological, 74 75 metabolic, 76 gastrointestinal 77–79 and musculoskeletal diseases. 80–83 …”

Section: Fluoro-d-glucose-pet/ctmentioning

confidence: 99%

Section: Macrophage-targeted Pet/ctmentioning

confidence: 99%

Metabolic and molecular imaging in inflammatory arthritis

Noversa de Sousa,

Tascilar,

Corte

et al. 2024

RMD Open

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Teachability of multispectral optoacoustic tomography

Li,

Gröhl,

Haney

et al. 2024

Journal of Biophotonics

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To date, the appropriate training required for the reproducible operation of multispectral optoacoustic tomography (MSOT) is poorly discussed. Therefore, the aim of this study was to assess the teachability of MSOT imaging. Five operators (two experienced and three inexperienced) performed repositioning imaging experiments. The inexperienced received the following introductions: personal supervision, video meeting, or printed introduction. The task was to image the exact same position on the calf muscle for seven times on five volunteers in two rounds of investigations. In the first session, operators used ultrasound guidance during measurements while using only photoacoustic data in the second session. The performance comparison was carried out with full‐reference image quality measures to quantitatively assess the difference between repeated scans. The study demonstrates that given a personal supervision and hybrid ultrasound real‐time imaging in MSOT measurements, inexperienced operators are able to achieve the same level as experienced operators in terms of repositioning accuracy.

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