Hybrid ultrasound‐<scp>MR</scp> guided <scp>HIFU</scp> treatment method with 3<scp>D</scp> motion compensation

Celicanin, Zarko; Manasseh, Gibran; Petrusca, Lorena; Scheffler, Klaus; Auboiroux, Vincent; Crowe, Lindsey A.; Hyacinthe, Jean-Noël; Natsuaki, Yutaka; Santini, Francesco; Becker, Christoph; Terraz, Sylvain; Bieri, Oliver; Salomir, Rarès

doi:10.1002/mrm.26897

Cited by 17 publications

(6 citation statements)

References 31 publications

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“…21 It also struggles to target moving tissue and is, therefore, most suitable in stationary organs such as the kidney and prostate. 22 The liver, for example, is not an ideal organ given that it is subject to both respiratory motion and sonic shadowing caused by the ribs, although there are methods such as single lung ventilation, 20 respiration control, 23 and 3D motion tracking 24 that mitigate these issues. Skin-burn can result in the event of poor acoustic coupling between the therapeutic window and the skin.…”

Section: High Intensity Focused Ultrasoundmentioning

confidence: 99%

Methods of monitoring thermal ablation of soft tissue tumors – A comprehensive review

et al. 2022

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Thermal ablation is a form of hyperthermia in which oncologic control can be achieved by briefly inducing elevated temperatures, typically in the range 50-80 • C, within a target tissue. Ablation modalities include high intensity focused ultrasound, radiofrequency ablation, microwave ablation, and laser interstitial thermal therapy which are all capable of generating confined zones of tissue destruction, resulting in fewer complications than conventional cancer therapies. Oncologic control is contingent upon achieving predefined coagulation zones; therefore, intraoperative assessment of treatment progress is highly desirable. Consequently, there is a growing interest in the development of ablation monitoring modalities. The first section of this review presents the mechanism of action and common applications of the primary ablation modalities. The following section outlines the state-of -the-art in thermal dosimetry which includes interstitial thermal probes and radiologic imaging. Both the physical mechanism of measurement and clinical or pre-clinical performance are discussed for each ablation modality. Thermal dosimetry must be coupled with a thermal damage model as outlined in Section 4. These models estimate cell death based on temperature-time history and are inherently tissue specific. In the absence of a reliable thermal model, the utility of thermal monitoring is greatly reduced. The final section of this review paper covers technologies that have been developed to directly assess tissue conditions. These approaches include visualization of non-perfused tissue with contrast-enhanced imaging, assessment of tissue mechanical properties using ultrasound and magnetic resonance elastography, and finally interrogation of tissue optical properties with interstitial probes. In summary, monitoring thermal ablation is critical for consistent clinical success and many promising technologies are under development but an optimal solution has yet to achieve widespread adoption.

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Section: High Intensity Focused Ultrasoundmentioning

confidence: 99%

Methods of monitoring thermal ablation of soft tissue tumors – A comprehensive review

et al. 2022

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“…To this end, many image-based sensors have been widely used in research such as high-speed camera/laparoscopy (Nakajima et al, 2014), Xray fluoroscopy (Ma et al, 2020), computed tomography (CT) (Su et al, 2013), magnetic resonance imaging (MRI) (Yang et al, 2014), positron emission tomography (PET) (Bettinardi et al, 2013), and ultrasound imaging (US) (Bowthorpe and Tavakoli, 2016a,b;Diodato et al, 2018). To get performance, hybrid imaging systems are also developed to measure precise organ motion including MRI/US imaging (Celicanin et al, 2018), MRI/CT imaging (Neumann et al, 2017), PET/CT imaging (Bettinardi et al, 2013;Pepin et al, 2014), and PET/MRI (Kolbitsch et al, 2018). The above-listed measurements have their advantages and limitations, which are elaborated in Table 1.…”

Section: Position Controlmentioning

confidence: 99%

COVID-19 Pandemic Spurs Medical Telerobotic Systems: A Survey of Applications Requiring Physiological Organ Motion Compensation

Cheng

Tavakoli

2020

Front. Robot. AI

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The coronavirus disease 2019 (COVID-19) pandemic has resulted in public health interventions such as physical distancing restrictions to limit the spread and transmission of the novel coronavirus, causing significant effects on the delivery of physical healthcare procedures worldwide. The unprecedented pandemic spurs strong demand for intelligent robotic systems in healthcare. In particular, medical telerobotic systems can play a positive role in the provision of telemedicine to both COVID-19 and non-COVID-19 patients. Different from typical studies on medical teleoperation that consider problems such as time delay and information loss in long-distance communication, this survey addresses the consequences of physiological organ motion when using teleoperation systems to create physical distancing between clinicians and patients in the COVID-19 era. We focus on the control-theoretic approaches that have been developed to address inherent robot control issues associated with organ motion. The state-of-the-art telerobotic systems and their applications in COVID-19 healthcare delivery are reviewed, and possible future directions are outlined.

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“…HIFU ablation of hepatic tissues is challenging due to respiratory motion, the presence of the rib cage and the proximity and risk to organs or major blood vessels [43][44][45][46][47]. Some techniques have been developed to solve the motion issue, such as applying sonications during the quasi-stationary period of the breathing cycle, namely gating, or using motioncompensation algorithms based on motion tracking to adjust the emitted power, the target or the position of the transducer [44,[47][48][49][50][51][52][53][54][55][56][57][58]. The rib cage is a major issue as it absorbs the acoustic beams and may inhibit the creation of a lesion, while increasing the risk of burns [51,59,60].…”

Section: Introductionmentioning

confidence: 99%

In Vivo Thermal Ablation of Deep Intrahepatic Targets Using a Super-Convergent MRgHIFU Applicator and a Pseudo-Tumor Model

Lorton

Peloso

et al. 2023

Cancers

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Background: HIFU ablation of liver malignancies is particularly challenging due to respiratory motion, high tissue perfusion and the presence of the rib cage. Based on our previous development of a super-convergent phased-array transducer, we aimed to further investigate, in vivo, its applicability to deep intrahepatic targets. Methods: In a series of six pigs, a pseudo-tumor model was used as target, visible both on intra-operatory MRI and post-mortem gross pathology. The transcostal MRgHIFU ablation was prescribed coplanar with the pseudo-tumor, either axial or sagittal, but deliberately shifted 7 to 18 mm to the side. No specific means of protection of the ribs were implemented. Post-treatment MRI follow-up was performed at D7, followed by animal necropsy and gross pathology of the liver. Results: The pseudo-tumor was clearly identified on T1w MR imaging and subsequently allowed the MRgHIFU planning. The peak temperature at the focal point ranged from 58–87 °C. Gross pathology confirmed the presence of the pseudo-tumor and the well-delineated MRgHIFU ablation at the expected locations. Conclusions: The specific design of the transducer enabled a reliable workflow. It demonstrated a good safety profile for in vivo transcostal MRgHIFU ablation of deep-liver targets, graded as challenging for standard surgery.

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Hybrid ultrasound‐MR guided HIFU treatment method with 3D motion compensation

Cited by 17 publications

References 31 publications

Methods of monitoring thermal ablation of soft tissue tumors – A comprehensive review

Methods of monitoring thermal ablation of soft tissue tumors – A comprehensive review

COVID-19 Pandemic Spurs Medical Telerobotic Systems: A Survey of Applications Requiring Physiological Organ Motion Compensation

In Vivo Thermal Ablation of Deep Intrahepatic Targets Using a Super-Convergent MRgHIFU Applicator and a Pseudo-Tumor Model

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