Hybrid umbilical cord blood banking: literature review

Laue, Jessica; Ambühl, Johanna; Surbek, Daniel

doi:10.1007/s00404-023-07003-x

Cited by 3 publications

(1 citation statement)

References 55 publications

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“…Prior to this survey, a systematic literature review was performed, which showed great potential for hybrid CB banking as an alternative to the pre-existing banking methods. 7 No study however addressed the women's perspectives on an available hybrid banking model.…”

Section: Discussionmentioning

confidence: 99%

Hybrid cord blood banking in a private‐public‐partnership: Women's perspectives

Laue,

Ambühl,

Surbek

2024

Transfusion

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BackgroundThe increasing demand for umbilical cord blood (UCB) used in stem cell transplantation led to the establishment of cord blood (CB) banks worldwide. These include public foreign donor banks and private family‐directed donor banks. Recently, our department has introduced a third banking model within a private‐public‐partnership. This hybrid banking allows for storage of family‐directed CB units, while also getting Human leukocyte antigen (HLA)‐typed and included in the national stem cell donor registry. So if the need arises, the HLA‐compatible CB unit can be released to an unrelated recipient as a foreign donor stem cell graft.ObjectivesThe aim of this study was to evaluate women's perspectives on the different CB banking options as well as retrospective satisfaction with their decisions.MethodsWe performed a prospective survey study in postpartum women, using a validated questionnaire.ResultsA total of 157 women were included in this survey study; 68% of them decided to have their UCB stored or donated. Among those women, 25% of them opted for hybrid storage, 72% of respondents stored UCB publicly, and 3% decided for private family‐directed storage.ConclusionsOur study shows the potential of hybrid banking as an attractive UCB storage option, as an alternative to family‐directed banking rather than a substitute for public donation. Hybrid storage potentially combines advantages of family‐directed banking as well as unrelated CB donation expanding the number of registered CB units available for transplantation and giving every pregnant woman the possibility to store UCB.

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Section: Discussionmentioning

confidence: 99%

Hybrid cord blood banking in a private‐public‐partnership: Women's perspectives

Laue,

Ambühl,

Surbek

2024

Transfusion

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Creation of a cell culture bank: experience of the Pokrovsky Cell Technology Center

Prikhodko,

Supilnikova,

Maslennikova

et al. 2024

Cardiovasc Ther Prev

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Modern research in cell biology places high demands on the model objects used, including cell cultures. These requirements are dictated by the need to avoid artifacts in work and reduce potential risks to the environment associated with biological hazard. The article presents the experience of creating cell culture bank for personal and public storage at the Pokrovsky Cell Technology Center. The main points of managing the collection, incoming quality control, certification, processing, preparation for storage and storage of human biological materials are considered. The developed approaches and work algorithms made it possible to create a collection of early passage cultures consisting of certified samples that meet the requirements for cell cultures for the manufacture of high-tech drugs and biomedical cell products, as well as for research.

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Knowledge, Attitudes, and Practices of Pregnant Women and Hospital Staff Regarding Umbilical Cord Blood Banking: Systematic Review and Meta-Analysis

Benvenuti,

Cavallini,

Battello

et al. 2024

Healthcare

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Background/Objectives: The aim of this study is to assess the knowledge, attitudes, and practices of pregnant women and hospital staff regarding umbilical cord blood (UCB) donation and storage to understand its limitations in clinical practice. Methods: MEDLINE, Scopus, LILACS, EMBASE, Scielo.br, and PROSPERO were searched from inception to 30 November 2023 with no geographic or language restrictions. The study eligibility criteria included cross-sectional studies that interviewed pregnant women and/or hospital staff about their knowledge, attitudes, and practices regarding private or public storage. A random-effects restricted maximum-likelihood model with Freeman–Tukey Double arcsine transformation meta-analysis was carried out to calculate the pooled estimates. MOOSE guidelines were followed. STATA 14.1 was used for statistical analysis. The Newcastle–Ottawa Scale and ROBINS-I tool were used for quality and risk of bias assessments. Results: In total, 19 studies providing data for 19,904 pregnant women and 1245 hospital staff members were included. Pooled pregnant women awareness was 61% ((95% CI 0.60 to 0.62), I2 = 0%, τ2 = 0.00, Q = 11.0 (p = 0.950)), and 61% for hospital staff (95% CI 0.58 to 0.64), I2 = 0%, τ2 = 0.00, Q = 4.00 (p = 0.310)). In total, 57% ((95% CI 0.56 to 0.58), I2 = 0, τ2 = 0.00, Q = 4.00 (p = 0.320)) of pregnant women had a positive attitude about UCB, while 34% ((95% CI 0.32 to 0.36), I2 = 0%, τ2 = 0.00, Q = 4.00 (p = 0.310)) were in favor of donating UCB for research and 65% ((95% CI 0.63 to 0.66), I2 = 0%, τ2 = 0.00, Q = 4.0 (p = 0.350)) were planning UCB storage. A significant (p < 0.001) preference for public relative to private banking (51% ([95% CI 0.49 to 0.54], I2 = 0%, τ2 = 0.00, Q = 4.0 (p = 0.310)) vs. 12% ([95% CI 0.10 to 0.13], I2 = 0%, τ2 = 0.00, Q = 4.0 (p = 0.300))) was noted for pregnant women. The same was retrievable for professionals (84% ([95% CI 0.79 to 0.88], I2 = 0%, τ2 = 0.00, Q = 2.0 (p = 0.110)) vs. 6% ([95% CI 0.03 to 0.09], I2 = 0%, τ2 = 0.00, Q = 1.0 (p = 0.070); p < 0.001)). Conclusions: Despite these efforts, lack of knowledge and positive attitudes about UCB banking remain, emphasizing the need for increasing educational programs on the subject.

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Hybrid umbilical cord blood banking: literature review

Cited by 3 publications

References 55 publications

Hybrid cord blood banking in a private‐public‐partnership: Women's perspectives

Hybrid cord blood banking in a private‐public‐partnership: Women's perspectives

Creation of a cell culture bank: experience of the Pokrovsky Cell Technology Center

Knowledge, Attitudes, and Practices of Pregnant Women and Hospital Staff Regarding Umbilical Cord Blood Banking: Systematic Review and Meta-Analysis

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