Hybrid verrucous squamous cell carcinoma of sinonasal tract: a case report

Abstract

Verrucous carcinoma is a variant of squamous cell carcinoma and should be distinguished from benign papilloma and well-differentiated nonverrucous squamous cell carcinoma. It is rare tumor of the sinonasal tract. Occasionally, conventional squamous cell carcinomatous components may be seen in verrucous carcinoma. This entity is called a hybrid verrucous squamous cell carcinoma. We report a case of hybrid verrucous squamous cell carcinoma occurring in the nasal cavity and paranasal sinus of a 67-year-old male. The removed mass shows the typical feature of verrucous carcinoma, but focally conventional squamous cell carcinomatous area is also noted. The treatment of this case follows verrucous carcinoma, but close follow up is mandatory because it may potentially spread to regional lymph nodes in contrast to pure form of verrucous carcinoma.

Verrucous carcinoma of the paranasal sinuses: Case report and clinical update

“…Although HPV types 6, 11, 16, and 18 have been detected to varying degrees in verrucous carcinoma of the oral cavity and the larynx, 22,23 Orvidas et al 24 could detect no HPV in association with nasal and paranasal sinus verrucous cancers using the polymerase chain reaction technique. Only one case of a hybrid tumor (elements of both verrucous carcinoma and typical squamous cell carcinoma on histologic evaluation) in the paranasal sinus has been described until now 25 but has not been included in the review, because these tumors behave more like squamous cell cancers. Of interest is the patient reported by Bacon et al, 26 who had been treated 10 years before the diagnosis of verrucous carcinoma by intranasal polypectomy.…”

Viral-Associated Nonmelanoma Skin Cancers: A Review

“…[56][57][58] The difficulty with these invasive lesions is whether to diagnose them as SCC or VC, which would ultimately affect the treatment plan due to the higher likelihood of lymph node metastasis of SCC. 55,59 Immunoperoxidase staining can be performed to differentiate between VC and SCC. Both VC and SCC cells can stain positively for bcl-2, Ki-67, and p53; however, the distribution of staining serves as a distinguishing feature.…”

Aggressive verrucous carcinoma of the paranasal sinuses invading the orbit: case report and literature review

“…22 Controversially, in situ hybridisation methods suggest that laryngeal papillomas may be related to HPV, but not to verrucous carcinomas. 34,40,41 Involvement of the nasolacrimal duct by any tumour may produce symptoms such as epiphora, bloodstained tears and epistaxis. The expression of p53 and epidermal growth factor receptor has been found to correlate significantly with verrucous carcinoma of the head and neck.…”

“…The clinical manifestations of verrucous carcinoma are closely related to the anatomical sites involved. In the sinonasal tract, verrucous carcinoma may resemble a nasal polyp or a pyocoele, with pus discharge from the nasal cavity 34 , 40 , 41 . Involvement of the nasolacrimal duct by any tumour may produce symptoms such as epiphora, blood-stained tears and epistaxis 42 – 44 .…”