Hydantoins and Thiohydantoins Derived from 1,2,3,4-Tetrahydroisoquinoline-3-carboxylic Acid

The review highlights the hydantoin syntheses presented from the point of view of the preparation methods. Novel synthetic routes to various hydantoin structures, the advances brought to the classical methods in the aim of producing more sustainable and environmentally friendly procedures for the preparation of these biomolecules, and a critical comparison of the different synthetic approaches developed in the last twelve years are also described. The review is composed of 95 schemes, 8 figures and 528 references for the last 12 years and includes the description of the hydantoin-based marketed drugs and clinical candidates.

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Coordination Compounds Based on 1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic Acid

Jansa

Macháček

Nachtigall

et al. 2007

Molecules

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Hydantoins and Thiohydantoins Derived from 1,2,3,4-Tetrahydroisoquinoline-3-carboxylic Acid

Cited by 4 publications

References 21 publications

Hydantoins and Thiohydantoins Derived from 1,2,3,4‐Tetrahydroisoquinoline‐3‐carboxylic Acid.

Hydantoins and Thiohydantoins Derived from 1,2,3,4‐Tetrahydroisoquinoline‐3‐carboxylic Acid.

Recent Advances in the Synthesis of Hydantoins: The State of the Art of a Valuable Scaffold

Coordination Compounds Based on 1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic Acid

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