Hydatidiform mole as seen in a university teaching hospital: A 10-year review

Bm, Audu; Iu, Takai; Cm, Chama; Bukar, Mohammed; Kyari, O

doi:10.1080/01443610902807345

Cited by 17 publications

(16 citation statements)

References 12 publications

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“…The incidence of molar pregnancies in the United States is 1 per 1000 pregnancies, in the United Kingdom 1.5 per 1000, and in Japan 2 per 1000 2,3,4 . In Nigeria, incidences of 3.8 per 1000 and 4.7 per 1000 deliveries were reported from Northeast and Southeast respectively 5,6 . In general, areas with high incidence of molar pregnancies have proportionately greater incidence of choriocarcinoma arising from hydatidiform mole 4 .…”

Section: Introductionmentioning

confidence: 99%

Gestational Trophoblastic Diseases in a Teaching Hospital in Northern, Nigeria

Yakasai¹

2015

AJBIO

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Background: Gestational trophoblastic diseases (GTD) is a spectrum of pregnancy-related premalignant disorders of complete and partial hydatidiform mole, and the malignant disorders of invasive mole, choriocarcinoma, and the rare placental-site trophoblastic tumour. Objective: This study was carried out to determine the incidence of gestational trophoblastic disease, the clinical features and management outcome at the Aminu Kano Teaching Hospital, Kano, Nigeria. Materials and Methods: This was a retrospective study of the demographic and clinical data as well as management outcome of all patients with gestational trophoblastic disease managed between January, 2008 and December, 2012 at the Aminu Kano Teaching Hospital. Kano,Nigeria Results: There were 103 cases of GTD and 22,680 deliveries; giving an incidence of GTD as 4.5 per 1000 deliveries. Among them, 69 (67.0%) cases were hydatidiform mole while Choriocarcinoma was diagnosed in 34 cases (33.0%). The antecedent pregnancy among the cases of choriocarcinoma were hydatidiform mole in 18 cases (52.9%), miscarriage in 10 cases (29.4%) and ectopic pregnancy in 1 case (3.0%) and full term pregnancy in 5(14.7%) patients. GTD was commoner at the extremes of reproductive age. Hydatidiform mole was high 37(53.6%) in those aged 24 years and below, while choriocarcinoma was high 13(38.2%) in 45 -49 years age group. The most common presenting symptom was vaginal bleeding occurring in all the cases, while anaemia was the most common complication. Suction evacuation and follow up (67.0%) was the mode of treatment in all cases of molar pregnancy. Only cases of choriocarcinoma 34 (33.0%) had chemotherapy, 11(32.4%) cases had single agent while 23 cases (67.6%) had multi-agent chemotherapy. There were seven maternal deaths in this study, given a case fatality of 6.8%. Conclusion: The incidence of GTD in this study was 4.5 per 1000 deliveries. Vaginal bleeding was the commonest presenting symptom. Early diagnosis and appropriate treatment of this disease has an excellent prognosis, while late presentation was associated with high maternal mortality as found in this study.

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Section: Introductionmentioning

confidence: 99%

Gestational Trophoblastic Diseases in a Teaching Hospital in Northern, Nigeria

Yakasai¹

2015

AJBIO

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“…[12456] It is controversial whether prophylactic chemotherapy following evacuation of complete hydatidiform mole should be offered to patients considered at high risk for persistent gestational trophoblastic disease or whom poor follow-up is anticipated. [9]…”

Section: Introductionmentioning

confidence: 99%

Hydatidiform mole: A review of management outcomes in a tertiary hospital in south-east Nigeria

Igwegbe

Eleje

2013

Ann Med Health Sci Res

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Background:Hydatidiform mole (molar pregnancy) is the pre-malignant form of gestational trophoblastic neoplasia. It is of clinical and epidemiological interest because of its significant complication in pregnancy.Aim:This study was to determine the incidence, risk factors, clinical presentations, diagnosis, treatment options, and outcomes of molar pregnancy in a Nigerian tertiary health institution.Materials and Methods:A 10-year retrospective study of patients with molar pregnancy managed at the hospital from 1st July 2001 to 30th June 2010 was undertaken.Results:There were 34 cases of molar pregnancy, out of a total delivery of 7,579, giving an incidence of 0.4% or 1 in 223 deliveries. The mean age of the patients was 31.3 (8.7) years, and 29.0% (9/31) of the patients were nulliparous. The mean gestational age of the patients at presentation was 14.7 (3.5) weeks. The most common presenting symptom was abnormal vaginal bleeding, 93.5% (29/31), while anemia was the commonest complication seen in 96.8% (30/31) of patients. Almost all the patients (93.5%) had suction evacuation while 6.5% (2/31) had hysterectomy. As many as 6.5% (2/31) of patients had post-evacuation chemotherapy while 87.1% (27/31) patients had follow-up contraception. As many as 64.5% (20/31) of patients had complete follow-up for less than 6 months. The case fatality rate was 9.7%.Conclusion:Molar pregnancy has remained an important cause of maternal morbidity and mortality in our hospital, and the incidence was high. There is need for early recognition, timely referral, prompt and proper treatment of this condition. Adequate follow-up of the patients should be reinforced.

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“…15 Patients with hydatidiform mole usually present with history of amenorrhoea, vaginal bleeding and spontaneous passage of grape-like vesicles. 2,3,4,6,8,9,[16][17][18][19][20][21][22] Molar pregnancy usually presents in the 4 th and 5 th month of pregnancy and should be suspected in any woman with vaginal bleeding in the first half of pregnancy 4 occurring in up to 92% of cases, 4,8 and passage of vesicles in 60% of patients. 4 Other rare presentations are hyperemesis gravidarum, pre-eclampsia, hyperthyroidism and symptomatic thecalutein cysts .…”

Section: Introductionmentioning

confidence: 99%

A Five-Year Retrospective Study of Gestational Trophoblastic Disease at University of Maiduguri Teaching Hospital Maiduguri, Nigeria

Ikechukwu

Usman

Onuegunam

2021

Int J Sci Healthcare Res

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Background: Gestational trophoblastic disease (GTD) is an uncommon complication of pregnancy. It is of clinical and epidemiological interest partly because of its good prognosis if detected and managed early. Objective: This study was to determine the prevalence, clinical presentation, management outcome and histologic types of GTDs at University of Maiduguri Teaching Hospital, Maiduguri, Nigeria. Methodology: A five-year retrospective study of histologically confirmed cases of GTDs managed in UMTH was undertaken. Folders of patient treated for GTD during the study period served as source of data. Statistical analysis was done using Statistical Package for the Social Sciences. Results: There were a total of 47 (38 molar and 9 choriocarcinoma) cases of GTDs that were diagnosed and managed at UMTH. However, only 40[31(77.5%)] molar and [9(22.5%) choriocarcinoma] case files were retrieved. 55% of the GTDs were complete hydatidiform mole, 22.5% partial hydatidiform mole and 22.5% choriocarcinoma. There was no case of invasive mole or placental site trophoblastic tumour noted. There were 15,426 deliveries in UMTH during this period giving the incidence of GTDs as 3.0 per 1000 deliveries or 1 in 328deliveries. The mean (SD) age of the patients was 30.5 ± 5.6years. Only 3(7.5%) of the patients were below 20 years of age and those who were at least 40 years of age constituted 8(20%). Low parity constituted 62.5% of the patients while 12.5% and 2.5% were nullipara and primipara respectively. The mean gestational age (SD) at presentation was 16.5±6.2 weeks. The common clinical presentations were amenorrhoea (100.0%), abnormal vaginal bleeding (97.5%), lower abdominal pain (90%) and passage of grape-like vesicles (45.0%). Only 6(15.0%) complied with the follow-up protocol for one year, while 25(62.5%) of the patients did not observe the follow-up protocol. Anaemia was the commonest complication observed. Conclusion: Gestational trophoblastic disease is relatively common in our center with an incidence of 3.0 per 1000 deliveries and 1.48% of our gynaecological admissions. Adequate patient counseling and compliance to follow-up are recommend for good outcome. Keywords: Prevalence, gestational trophoblastic disease, Hydatidiform mole, Choriocarcinoma, Maiduguri.

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Hydatidiform mole as seen in a university teaching hospital: A 10-year review

Cited by 17 publications

References 12 publications

Gestational Trophoblastic Diseases in a Teaching Hospital in Northern, Nigeria

Gestational Trophoblastic Diseases in a Teaching Hospital in Northern, Nigeria

Hydatidiform mole: A review of management outcomes in a tertiary hospital in south-east Nigeria

A Five-Year Retrospective Study of Gestational Trophoblastic Disease at University of Maiduguri Teaching Hospital Maiduguri, Nigeria

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