Hydralazine induced Membranous Nephritis and RPGN

Abstract

It is already well known that Hydralazine can induce ANCA associated vasculitis(mentioned as AAV) and Pauci-Immune RPGN which is sometimes associated with pulmonary renal syndrome [1,2]. Hydralazine induced membranous nephritis has never been documented before. We present a case of hydralazine induced RPGN, with biopsy findings of Membranous Glomerulonephritis. This is a unique presentation of hydralazine induced renal failure and helps us to study the spectrum of pathological reactions induced from this drug. This case study also reviews the pathological similarities in the hydralazine induced reactions and SLE and discusses the treatment of such pathology.