Hydramnios in the third trimester of pregnancy:A change in the distribution of accompanying fetal anomalies as a result of early ultrasonographic prenatal diagnosis

Benchetrit, Alison; Hochner‐Celnikier, D.; Ron, M.; Yagel, S.

doi:10.1016/0002-9378(90)90058-f

Cited by 41 publications

(21 citation statements)

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“…Ben-Chetrit et al [13] also studied the spectrum of abnormalities associated with polyhydramnios. In their study, gastrointestinal malformations (39%) were most frequent, followed by abnormalities of the CNS (26%), circulatory (22%), and urinary tract (13%) anomalies.…”

Section: Discussionmentioning

confidence: 99%

Idiopathic Polyhydramnios and Postnatal Abnormalities

et al. 2012

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Objective: To investigate the proportion and type of fetal anomalies that are associated with polyhydramnios and to examine whether in cases with idiopathic polyhydramnios during the course of pregnancy and fetal anomalies only diagnosed after birth, antenatal characteristics differ. Methods: This was a retrospective study involving all pregnancies with polyhydramnios defined by a deepest pool of amniotic fluid ≥8 cm and a detailed ultrasound examination, a 75 g glucose tolerance test and a TORCH serology. Results: Between 2004 and 2010, 272 pregnancies fulfilled the inclusion criteria. In 89 (32.7%) and 65 (23.9%) cases, there was a fetal anomaly or diabetes. In 118 (43.4%) pregnancies, polyhydramnios was classified as idiopathic. In 11 (9.3%) of the 118 fetuses, an anomaly was found after birth, mainly gastrointestinal atresia. In these cases, median deepest pool of amniotic fluid was 9.6 cm, and median estimated fetal weight was at the 69th centile, whereas in cases without anomalies diagnosed after birth, median deepest pool was 9.0 cm and median estimated fetal weight at the 90th centile (Mann-Whitney U test: deepest pool p = 0.116, and estimated fetal weight centile p = 0.377). There was also no difference in the maternal and gestational age distribution of these cases (Mann-Whitney U test: maternal age p = 0.293, and gestational age p = 0.499). Conclusion: In about 40% of pregnancies, polyhydramnios remains unexplained during the course of pregnancy. In 10% of these cases, an anomaly will only be found after birth. In this group, antenatal characteristics such as amniotic fluid volume, estimated fetal weight or gestational and maternal age at the time of diagnosis do not help to detect these anomalies before birth.

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Section: Discussionmentioning

confidence: 99%

Idiopathic Polyhydramnios and Postnatal Abnormalities

et al. 2012

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“…The etiology of polyhydramnios is diverse, involving both maternal and fetal disorders. Causes include underlying congenital fetal structural abnormalities, fetal infections, multiple gestations, isoimmunization, fetal–maternal hemorrhage, placental tumors and maternal diabetes, but up to 50% of cases are idiopathic . Fetal infections most commonly linked to polyhydramnios are cytomegalovirus (CMV), toxoplasmosis, syphilis, rubella and parvovirus B19 infection .…”

Section: Introductionmentioning

confidence: 99%

Prevalence of a positive TORCH and parvovirus B19 screening in pregnancies complicated by polyhydramnios

et al. 2016

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Objective The aim of this study was to evaluate the rate of women with polyhydramnios who eventually screened positive to infectious disease by serum screening testing for TORCH and parvovirus B19.Methods This is a retrospective observational study on singleton pregnancies with a diagnosis of polyhydramnios and who had serum screening for TORCH and parvovirus B19. Patients were followed with serial ultrasounds between 2006 and 2013. Maternal characteristics, medical and obstetric history were reviewed. Ultrasound parameters, including amniotic fluid index and fetal anomalies, and the results of serologic tests were reviewed.Results Two hundred ninety patients met the inclusion criteria. Of these, 56 (19%) presented one of the following pathological conditions associated with polyhydramnios: diabetes (13% of total cases), obstructive gastrointestinal lesions (5%), Rhesus isoimmunization (0.3%), chromosomal abnormalities or genetic syndromes (1%). Among the remaining 234 patients, only three had a positive test result for infectious disease (1%, 95% Confidence Interval (CI) 0-4%): two women were positive for parvovirus B19 and one for toxoplasmosis infection. In none of them the fetus was affected, as confirmed by serum testing after birth and by 3 years follow-up.Conclusions Infectious disease screening does not seem beneficial in pregnancies with isolated polyhydramnios

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“…Most commonly affected system was central nervous system (52.5%).Other anomalies involved gastrointestinal (17.5%) and genitourinary tract (10%). The common CNS malformations found were hydrocephalous (10) and anencephaly (9). Six babies had gastrointestinal anomalies of which two babies had trachea-esophageal fistula and another two had diaphragmatic hernia.…”

Section: Resultsmentioning

confidence: 99%

“…11.5% had musculoskeletal anomalies, 10% had GIT anomalies and 9% had CVS anomalies. Ben Chetrit et al (9) found that 20% of cases were associated with congenital malformations. Gastrointestinal anomalies were the commonest (39%) and these included duodenal atresia, diaphragmatic hernia, esophageal atresia and omphalocele.…”

Section: Discussionmentioning

confidence: 99%