2020
DOI: 10.1021/acs.cgd.0c00655
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Hydrate Transformation via Anhydrate Pairs

Abstract: Here we present an example of an unusual hydrate−anhydrate transformation process induced by defects. Crystallization of uric acid in the presence of substoichiometric concentrations of 2,4-diaminopyrimidine (24-DAP) additives results in uric acid dihydrate (UAD) prisms with trace amounts of 24-DAP included. Prisms maintained in the growth solution transform to anhydrous uric acid (UA) via a highly unusual mechanism in which pairs of thin UA plates emerge from the center of the UAD prism faces which bisect the… Show more

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Cited by 2 publications
(4 citation statements)
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“…The crystallographic data and refinement details are presented in Table S3. It was found that MC crystallizes in the space group P2 1 /c including one UA and two water molecules, which is consistent with previous reports (Parkin & Hope, 1998;Artioli et al, 1997;Thornton et al, 2020;Izatulina et al, 2019). But here we also found the presence of disordered UA molecules in the crystal structure with the chemical occupancy 0.688:0.312, as shown in Fig.…”
Section: Mechanism Of the Core-shell Phase Transitionsupporting
confidence: 93%
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“…The crystallographic data and refinement details are presented in Table S3. It was found that MC crystallizes in the space group P2 1 /c including one UA and two water molecules, which is consistent with previous reports (Parkin & Hope, 1998;Artioli et al, 1997;Thornton et al, 2020;Izatulina et al, 2019). But here we also found the presence of disordered UA molecules in the crystal structure with the chemical occupancy 0.688:0.312, as shown in Fig.…”
Section: Mechanism Of the Core-shell Phase Transitionsupporting
confidence: 93%
“…The metastable phase UAD can spontaneously transform to UAA through either solid-state dehydration in air or solvent-mediated phase transformation in aqueous solution (Zellelow et al, 2010a;Presores & Swift, 2014). A recent study by Swift and coworkers suggested that the defects induced by trace amounts of 2,4-diaminopyrimidine may impact the kinetics of the solid-state dehydration transition from UAD to UAA (Thornton et al, 2020). However, the unique core-shell phase transition reported in this work was not observed in any of these investigations.…”
contrasting
confidence: 52%
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“…S1†), stronger characteristic peaks (590, 630, 1012, 1062 cm −1 ) of MSUM appear close to those of UAA and UAD at 550–630 cm −1 and 1000–1065 cm −1 , respectively. In addition, the Raman spectra between UAD and UAA appear quite similar and the discernible differences are at 1431–1640 cm −1 and 1404–1650 cm −1 corresponding to UAD and UAA, 41 respectively (Fig. 2b).…”
Section: Resultsmentioning
confidence: 87%