Hydration and Obesity among Outpatient-Based Population: H2Ob Study

Abstract

Recent evidence suggests that obese people are hypohydrated and that water consumption may be a useful indicator for the prevention and treatment of obesity. Nevertheless, there is no agreement regarding the best hydration status indicators and there are few data about the relationship between hydration and body weight. In the present study, we aim to analyze the correlation among hydration status with obesity measured by three different methods (plasma osmolarity, urinary specific gravity (USG) and urinary osmolarity) in a hospital-based outpatient population. We have carried out a cross-sectional study to evaluate the association between obesity and hydration status in 260 patients, average 56.5±15.7 years. Hydration status was estimated by means of plasma osmolarity, urine osmolarity and USG. We did show significant trend of higher urine osmolarity (P=0.03), USG (P=0.000) and plasma osmolarity (P=0.000) with an increase of weight status categories, more accurate in the case of plasma osmolarity. In a multivariate analysis, after controlled by confounders, we found that obesity was associated with plasma osmolarity (OR 1.09; 95% CI 1.02 to 1.17, P=0.009), urine osmolarity (OR 1.00; 95% CI 1.00 to 1.01, P=0.05) and USG (OR 1.02; 95% CI 1.00 to 1.04, P=0.05). Our results have shown a more accurate relationship between plasma osmolarity with all body mass index categories. This finding may have clinical implications that must be confirmed in further studies.

Randomized Trial to Assess the Safety and Tolerability of Daily Intake of an Allulose Amino Acid-Based Hydration Beverage in Men and Women

“…This study recruited subjects between the ages of 18 and 50 years, as this is the anticipated primary age range of the consumer audience of hydration products. Subjects had a body mass index (BMI) between 20 and 29.9 kg/m 2 (not obese), with higher values being excluded to reduce the variability in hydration status since individuals with obesity consume less water than those of normal weight [ 14 , 15 ]. Study inclusion was restricted to adult subjects who were healthy with no history of chronic health concerns such as a major affective disorder, cardiovascular disease, diabetes, and gastrointestinal disorders, as well as being smoke-free (e.g., non-tobacco or vape user).…”