2008
DOI: 10.1002/jssc.200700426
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Hydration, charge, size, and shape characteristics of peptides from their CZE analyses

Abstract: A CZE model is presented for peptide characterization on the basis of well-established physicochemical equations. The effective mobility is used as basic data in the model to estimate relevant peptide properties such as, for instance, hydration, net and total electrical charge numbers, hydrodynamic size and shape, particle average orientation, and pH-microenvironment from the charge regulation phenomenon. Therefore 102 experimental effective mobilities of different peptides are studied and discussed in relatio… Show more

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Cited by 23 publications
(96 citation statements)
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“…In Equation (1), [15,34]. In this work, we found appropriate to estimate, as a first approximation, a fractional weight averaged electrical permittivity within the domain of the protein through e 0 ¼ ed=ð1 þ dÞ þ e p =ð1 þ dÞ, where e p % 5 e o is an approximate value of the dry protein electrical permittivity [34] and d is the convergent value coming from the numerical iteration process described elsewhere [17]. Also e o is the vacuum electrical permittivity.…”
Section: The Pllcem For Proteinsmentioning
confidence: 99%
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“…In Equation (1), [15,34]. In this work, we found appropriate to estimate, as a first approximation, a fractional weight averaged electrical permittivity within the domain of the protein through e 0 ¼ ed=ð1 þ dÞ þ e p =ð1 þ dÞ, where e p % 5 e o is an approximate value of the dry protein electrical permittivity [34] and d is the convergent value coming from the numerical iteration process described elsewhere [17]. Also e o is the vacuum electrical permittivity.…”
Section: The Pllcem For Proteinsmentioning
confidence: 99%
“…Here, in the PLLCEM the equivalent spherical model (ESM) of CZE is used again, which has been illustrated in [16,17,22] and validated in particular for spheroidal particles of low eccentricity, usually selected as prototype hydrodynamic shapes for proteins and peptides. The ESM has also been used widely in the literature and in basic texts to estimate diffusion and sedimentation coefficients [32,33].…”
Section: The Pllcem For Proteinsmentioning
confidence: 99%
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