Hydration effects of moisturizing gel on normal skin: A pilot study

Goh, Joanna Xuan Hui; Tan, Loh Teng‐Hern; Yew, Han Choi; Pusparajah, Priyia; Lingham, P.; Long, Chiau Ming; Lee, Learn‐Han; Goh, Bey Hing

doi:10.36877/pddbs.a0000023

Cited by 4 publications

(4 citation statements)

References 40 publications

(43 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Hence, for future studies, further fractionation of the current existing fractions should be conducted to improve their efficacy against photoaging. Next, the creation of cosmetic formulation with S. macrophylla fractions as the active ingredient and in vivo human clinical testing of said formula on skin hydration, elasticity, sebum production, and pigmentation can also be conducted, as described by Tian et al [ 122 ], Goh et al [ 123 ], Adejokun and Dodou [ 124 ], and Mosquera et al [ 125 ], to better study its anti-photoaging effect on the skin.…”

Section: Resultsmentioning

confidence: 99%

Counteracting the Ramifications of UVB Irradiation and Photoaging with Swietenia macrophylla King Seed

et al. 2021

Self Cite

View full text Add to dashboard Cite

In this day and age, the expectation of cosmetic products to effectively slow down skin photoaging is constantly increasing. However, the detrimental effects of UVB on the skin are not easy to tackle as UVB dysregulates a wide range of molecular changes on the cellular level. In our research, irradiated keratinocyte cells not only experienced a compromise in their redox system, but processes from RNA translation to protein synthesis and folding were also affected. Aside from this, proteins involved in various other processes like DNA repair and maintenance, glycolysis, cell growth, proliferation, and migration were affected while the cells approached imminent cell death. Additionally, the collagen degradation pathway was also activated by UVB irradiation through the upregulation of inflammatory and collagen degrading markers. Nevertheless, with the treatment of Swietenia macrophylla (S. macrophylla) seed extract and fractions, the dysregulation of many genes and proteins by UVB was reversed. The reversal effects were particularly promising with the S. macrophylla hexane fraction (SMHF) and S. macrophylla ethyl acetate fraction (SMEAF). SMHF was able to oppose the detrimental effects of UVB in several different processes such as the redox system, DNA repair and maintenance, RNA transcription to translation, protein maintenance and synthesis, cell growth, migration and proliferation, and cell glycolysis, while SMEAF successfully suppressed markers related to skin inflammation, collagen degradation, and cell apoptosis. Thus, in summary, our research not only provided a deeper insight into the molecular changes within irradiated keratinocytes, but also serves as a model platform for future cosmetic research to build upon. Subsequently, both SMHF and SMEAF also displayed potential photoprotective properties that warrant further fractionation and in vivo clinical trials to investigate and obtain potential novel bioactive compounds against photoaging.

show abstract

Section: Resultsmentioning

confidence: 99%

Counteracting the Ramifications of UVB Irradiation and Photoaging with Swietenia macrophylla King Seed

et al. 2021

Self Cite

View full text Add to dashboard Cite

show abstract

“…HA being a natural component of the skin, has been one of the most favorite humectant used in almost all nutricosmetic products with moisturizing properties ( Bukhari et al., 2018 ). It helps in attracting and retaining fluid, and skin barrier repair ( Maytin et al., 2004 ; Goh et al., 2019 ). However it is rarely used primarily as a sole ingredient, but rather working synergistically with other category of moisturizer to achieve its role in skin repair ( Draelos, 2011 ; Frankel et al., 2011 ; Pacha and Hebert, 2012 ; Micali et al., 2018 ).…”

Section: Ha In Medical Device Moisturizersmentioning

confidence: 99%

Hyaluronic Acid-Mediated Drug Delivery System Targeting for Inflammatory Skin Diseases: A Mini Review

et al. 2020

View full text Add to dashboard Cite

Hyaluronic acid (HA), a major component of extracellular matrix has been widely applied in pharmaceutical and cosmetic industries due to its reported pharmacological properties. Various types of HA drug delivery system including nanoparticles, cryogel-based formulations, microneedle patches, and nano-emulsions were developed. There are studies reporting that several HA-based transdermal delivery systems exhibit excellent biocompatibility, enhanced permeability and efficient localized release of anti-psoriasis drugs and have shown to inhibit psoriasis-associated skin inflammation. Similarly HA is found in abundant at epidermis of atopic dermatitis (AD) suggesting its role in atopic AD pathology. Anti-allergenic effect of atopic eczema can be achieved through the inhibition of CD44 and protein kinase C alpha (PKCa) interaction by HA. Herein, we aim to evaluate the current innovation on HA drug delivery system and the other potential applications of HA in inflammatory skin diseases, focusing on atopic dermatitis and psoriasis. HA is typically integrated into different delivery systems including nanoparticles, liposomes, ethosomes and microneedle patches in supporting drug penetration through the stratum corneum layer of the skin. For instance, ethosomes and microneedle delivery system such as curcumin-loaded HA-modified ethosomes were developed to enhance skin retention and delivery of curcumin to CD44-expressing psoriatic cells whereas methotrexate-loaded HA-based microneedle was shown to enhance skin penetration of methotrexate to alleviate psoriasis-like skin inflammation. HA-based nanoparticles and pluronic F-127 based dual responsive (pH/temperature) hydrogels had been described to enhance drug permeation through and into the intact skin for AD treatment.

show abstract

“…The dryness of the skin will be visible from the surface of the water content in SC is less than 10%. (Kubo & Amagai, 2019;Rihatmadja, 2015;Goh et al, 2019) Healthy skin is moist skin with adequate moisture content so that the skin looks smooth and elastic (Lynde, 2001;Verdier-Sevrain & Bonte, 2007). It consists of 3 layers with the epidermis on the top layer.…”

Section: Introductionmentioning

confidence: 99%

Skin Moisture Profile of Normal Skin and Inflammatory Skin Disease Using Skin Analyzer

2022

Nusantara Science and Technology Proceedings

View full text Add to dashboard Cite

The skin has several functions which related to each other. It consists of 3 layers with EHT epidermis on the top layer. It serves to provide a barrier of protection against skin external threats and has one of the important functions of the skin. The structure of the stratum corneum is the main factor that regulates the transportation of fluid in the skin to retain skin moisture. One of the characteristics of healthy skin is moisture. Dry skin is prone to dermatoses, such as dermatitis. Since skin moisture is important, we need to measure the level of water in the epidermis. The faster the diagnosis, the faster the treatment. This study uses a cross-sectional design, conducted at one of the general hospitals in Pekanbaru. Skin moisture examination was carried out by determining the percentage of water content in the epidermis using a portable skin analyzer on the skin surface of healthy people, and normal (non-lesional skin lesions) of subjects diagnosed with dermatitis. The mean of subjects without dermatoses is 36,4, the non-lesional skin of subjects with dermatoses is 36.4, and the skin lesion of the subject was 12,6. Data were analyzed by t-test. There is a significant difference between non-lesional and lesional skin with a p-value <0,05.

show abstract

Hydration effects of moisturizing gel on normal skin: A pilot study

Cited by 4 publications

References 40 publications

Counteracting the Ramifications of UVB Irradiation and Photoaging with Swietenia macrophylla King Seed

Counteracting the Ramifications of UVB Irradiation and Photoaging with Swietenia macrophylla King Seed

Hyaluronic Acid-Mediated Drug Delivery System Targeting for Inflammatory Skin Diseases: A Mini Review

Skin Moisture Profile of Normal Skin and Inflammatory Skin Disease Using Skin Analyzer

Contact Info

Product

Resources

About