“…While these genetic algorithms show promising applications in cluster formation studies involving acids and bases, they rely on treating the molecules as rigid in the global optimization using a force field, which makes the methods difficult to apply to systems containing organic molecules with many rotamers. Recently, Rasmussen et al (Rasmussen et al, 2020)coupled the approach outlined by Kubečka et al (Kubečka et al, 2019) with the systematic hydrate sampling approach by Kildgaard et al (Kildgaard et al, 2018a,b) for studying the shallow potential free energy surface of sulfuric acid -water clusters. This approach appears to be a viable approach to study multicomponent atmospheric molecular clusters involving water.…”